Obesity-Hypertension Physiopathology and Treatment: A Forty-Year Retrospect

  • Jonathan Owen
  • Stephen Morse
  • Angela McLean
  • Efrain ReisinEmail author
Part of the Updates in Hypertension and Cardiovascular Protection book series (UHCP)


During the past 40 years of research into obesity, hypertension, and chronic kidney disease, we have gained considerable knowledge on the effects of excess weight gain to alter numerous metabolic and hormonal processes, which can ultimately result in type 2 diabetes, hypertension, cardiovascular disease, and chronic kidney failure. Over this span of time, we have witnessed the naming of these metabolic and hormonal alterations as a new condition, the Metabolic Syndrome. Additionally, we have noted that hypertension in obesity appears to have some unique differences to essential hypertension in the normal weight population, and have preferred the term Obesity-Hypertension in our description of this process. The obesity epidemic worldwide has continued to surge unabated resulting in the search for new ways to reduce body weight by dietary means, pharmaceutical means, and surgical intervention. This review will focus on an overview of this condition from insights gained over the preceding 40 plus years of research and clinical experience in this field, with an emphasis on Obesity-Hypertension and therapeutic options.


Obesity-hypertension Metabolic syndrome Insulin resistance Visceral adiposity Chronic kidney disease Dyslipidemia Microalbuminuria RAAS Leptin Ghrelin SNS Bariatric surgery Weight loss 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Jonathan Owen
    • 1
  • Stephen Morse
    • 2
  • Angela McLean
    • 3
  • Efrain Reisin
    • 2
    Email author
  1. 1.Division of Nephrology, Department of Internal MedicineUniversity of New Mexico Health Sciences CenterAlbuquerqueUSA
  2. 2.Section of Nephrology and Hypertension, Department of MedicineLouisiana State University Health Sciences CenterNew OrleansUSA
  3. 3.Section of Internal Medicine, Department of MedicineLouisiana State University Health Sciences CenterNew OrleansUSA

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