Hemodynamics of Prehypertension
Hemodynamic investigations in prehypertensive people have revealed that already at this early stage of hypertension, total peripheral resistance is increased. This is true even in situations where cardiac output is elevated. Heart rate and arterial stiffness are clearly higher as well in prehypertensives as compared to normotensives. As far as the peripheral circulation has been studied, this shows abnormalities in prehypertension which are also consistent with an increased resistance to flow. Altogether, there is not enough evidence to conclude that hypertension evolves from a high-output to a high-resistance state. Rather, the increase in resistance is a primary phenomenon.
KeywordsCardiac output Heart rate Prehypertension Autonomic control Renal Arterial stiffness
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