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GH/IGF-I and Bone

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Multidisciplinary Approach to Osteoporosis

Abstract

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are relevant regulators of bone homeostasis throughout human life, acting on both the trabecular and cortical bone [1]. The anabolic effects of these hormones are important to reach an adequate bone mass during puberty and early adulthood—a critical determinant for the future risk of osteoporosis—and for the maintenance of skeletal health during adult life [2–4]. The precise time of the attainment of peak bone mass is not clear-cut, but it is skeletal-site dependent, and the gonadal status plays a noteworthy role in regulating bone accretion [5].

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Authors and Affiliations

  1. Chair of Endocrinology, Università Vita-Salute San Raffaele, Milan, Italy

    Stefano Frara, Mauro Doga & Andrea Giustina

  2. ASST Spedali Civili, Brescia, Italy

    Filippo Maffezzoni & Anna Maria Formenti

  3. Endocrinology Unit, ASST Carlo Poma, Mantua, Italy

    Gherardo Mazziotti

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  1. Stefano Frara
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  2. Filippo Maffezzoni
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  3. Mauro Doga
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  4. Anna Maria Formenti
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  5. Gherardo Mazziotti
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  6. Andrea Giustina
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Editors and Affiliations

  1. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

    Andrea Lenzi

  2. Department of Movement, Human and Health Sciences, Foro Italico University of Rome, Rome, Italy

    Silvia Migliaccio

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Frara, S., Maffezzoni, F., Doga, M., Formenti, A.M., Mazziotti, G., Giustina, A. (2018). GH/IGF-I and Bone. In: Lenzi, A., Migliaccio, S. (eds) Multidisciplinary Approach to Osteoporosis. Springer, Cham. https://doi.org/10.1007/978-3-319-75110-8_6

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