Metabolic Crosstalk Between Host and Parasitic Pathogens

  • Diana Moreira
  • Jérôme Estaquier
  • Anabela Cordeiro-da-Silva
  • Ricardo Silvestre
Chapter
Part of the Experientia Supplementum book series (EXS, volume 109)

Abstract

A complex network that embraces parasite–host intrinsic factors and the microenvironment regulated the interaction between a parasite and its host. Nutritional pressures exerted by both elements of this duet thus dictate this host–parasite niche. To survive and proliferate inside a host and a harsh nutritional environment, the parasites modulate different nutrient sensing pathways to subvert host metabolic pathways. Such mechanism is able to change the flux of distinct nutrients/metabolites diverting them to be used by the parasites. Apart from this nutritional strategy, the scavenging of nutrients, particularly host fatty acids, constitutes a critical mechanism to fulfil parasite nutritional requirements, ultimately defining the host metabolic landscape. The host metabolic alterations that result from host–parasite metabolic coupling can certainly be considered important targets to improve diagnosis and also for the development of future therapies. Metabolism is in fact considered a key element within this complex interaction, its modulation being crucial to dictate the final infection outcome.

Keywords

Nutrient sensing pathways Host–parasite interaction Host metabolic pathways Scavenging of nutrients Host metabolic landscape 

Notes

Funding Statement

This work was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013) and the Fundação para a Ciência e Tecnologia (FCT) contracts IF/00021/2014 to RS and INFECT-ERA (Project INLEISH).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Diana Moreira
    • 1
    • 2
    • 3
    • 4
    • 5
  • Jérôme Estaquier
    • 6
    • 7
  • Anabela Cordeiro-da-Silva
    • 3
    • 4
    • 5
  • Ricardo Silvestre
    • 1
    • 2
  1. 1.Life and Health Sciences Research Institute (ICVS), School of MedicineUniversity of MinhoBragaPortugal
  2. 2.ICVS/3B’s-PT Government Associate LaboratoryBraga/GuimarãesPortugal
  3. 3.i3S-Instituto de Investigacão e Inovação em SaúdeUniversidade do PortoPortoPortugal
  4. 4.IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal
  5. 5.Departamento de Ciências Bioloógicas, Faculdade de FarmaáciaUniversidade do PortoPortoPortugal
  6. 6.CNRS FR 3636, Université Paris DescartesParisFrance
  7. 7.Centre de Recherche du CHU de QuébecUniversité LavalQuébecCanada

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