Metabolic Regulation of Innate Immunity to Fungal Infection

  • Cláudia S. Rodrigues
  • Cláudia F. Campos
  • Cristina Cunha
  • Agostinho Carvalho
Part of the Experientia Supplementum book series (EXS, volume 109)


In recent years, the renewed interest in immune cell metabolism has driven the emergence of a research field aimed at studying the role of metabolic processes during innate and adaptive immune responses. Although the specific requirements of myeloid cells after the canonical lipopolysaccharide/TLR4 stimulation have been extensively addressed, recent evidence suggests that this model may not represent a universally accurate metabolic blueprint. Instead, different microbial stimuli, pathogens, or tissue microenvironments trigger specific and complex metabolic rewiring of myeloid cells. This chapter aims to provide an overview of the metabolic heterogeneity in activated myeloid cells during fungal disease. Directions for future research in dissecting the uniqueness of metabolic signatures during fungal infection are suggested to ultimately provide new tailored diagnostic and therapeutic interventions.


Fungal disease Immunometabolism β-glucan Trained immunity Epigenetics 



This work was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), and the Fundação para a Ciência e Tecnologia (FCT) (IF/00735/2014 to AC and SFRH/BPD/96176/2013 to CC).


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Cláudia S. Rodrigues
    • 1
    • 2
  • Cláudia F. Campos
    • 1
    • 2
  • Cristina Cunha
    • 1
    • 2
  • Agostinho Carvalho
    • 1
    • 2
  1. 1.Life and Health Sciences Research Institute (ICVS), School of MedicineUniversity of MinhoBragaPortugal
  2. 2.ICVS/3B’s - PT Government Associate LaboratoryBraga/GuimarãesPortugal

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