Skip to main content
SpringerLink
Log in
Book cover

Methane Biocatalysis: Paving the Way to Sustainability pp 67–82Cite as

Metals in Methanotrophy

  • Chapter
  • First Online:

Abstract

Metals play a pivotal role during one-carbon metabolism as they are important catalysts for numerous enzymatic reactions, can be used for electron transfer, enable radical chemistry, and enhance enzymatic substrate affinity. Metals also coordinate the expression of genes that are involved in their own sensing, sequestration, transport, storage, and use to ensure that their accumulation does not become toxic. Metals such as copper (Cu), iron (Fe), lanthanides (Ln), cobalt (Co), zinc (Zn), molybdenum (Mo), and tungsten (W) are particularly important for methanotrophy. This chapter will describe the role in catalysis for each one of these micronutrients along with the structural and mechanistic details of important catalytic centers. Sensing, uptake, and sequestration mechanisms will be highlighted along with changes in metabolism due to metal limitations during environmental and biotechnological processes. The diverse metal-dependent regulatory effects during methanotrophy will also be addressed, and metal-dependent advances in biotechnology and sustainability will be briefly described.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Acheson JF, Bailey LJ, Elsen NL, Fox BG (2014) Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system. Nat Commun 5:5009

    Article  CAS  PubMed  Google Scholar 

  • Anthony C (1986) Bacterial oxidation of methane and methanol. Adv Microb Physiol 27:113–210

    Article  CAS  PubMed  Google Scholar 

  • Balasubramanian R, Smith SM, Rawat S, Yatsunyk LA, Stemmler TL, Rosenzweig AC (2010) Oxidation of methane by a biological dicopper centre. Nature 465:115–119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Balasubramanian R, Rosenzweig AC (2007) Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase. Acc Chem Res 40:573–580

    Article  CAS  PubMed  Google Scholar 

  • Basu P, Katterle B, Andersson KK, Dalton H (2003) The membrane-associated form of methane mono-oxygenase from Methylococcus capsulatus (Bath) is a copper/iron protein. Biochem J 369:417–427

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Behling LA, Hartsel SC, Lewis DE, DiSpirito AA, Choi DW, Masterson LR, Veglia G, Gallagher WH (2008) NMR, mass spectrometry and chemical evidence reveal a different chemical structure for methanobactin that contains oxazolone rings. J Am Chem Soc 130:12604–12605

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blanksby SJ, Ellison GB (2003) Bond dissociation energies of organic molecules. Acc Chem Res 36:255–263

    Article  CAS  PubMed  Google Scholar 

  • Bogart JA, Lewis AJ, Schelter EJ (2015) DFT study of the active site of the XoxF-type natural, cerium-dependent methanol dehydrogenase enzyme. Chemistry 21:1743–1748

    Article  CAS  PubMed  Google Scholar 

  • Chatwood LL, Müller J, Gross JD, Wagner G, Lippard SJ (2004) NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath). Biochemistry 43:11983–11991

    Article  CAS  PubMed  Google Scholar 

  • Chistoserdova L (2011) Modularity of methylotrophy, revisited. Environ Microbiol 13:2603–26022

    Article  CAS  PubMed  Google Scholar 

  • Choi DW, Kunz RC, Boyd ES et al (2003) The membrane-associated methane monooxygenase (pMMO) and pMMO-NADH: quinone oxidoreductase complex from Methylococcus capsulatus Bath. J Bacteriol 185:5755–5764

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chou HH, Berthet J, Marx CJ (2009) Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation. PLoS Genetics 5:e1000652

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chu F, Beck DA, Lidstrom ME (2016) MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense. Peer J 4:e2435

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chu F, Lidstrom ME (2016) XoxF acts as the predominant methanol dehydrogenase in the Type I methanotroph Methylomicrobium buryatense. J Bacteriol 198:1317–1325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Colby J, Dalton H (1979) Characterization of the second prosthetic group of the flavoenzyme NADH-acceptor reductase (component C) of the methane monooxygenase of Methylococcus capsulatus (Bath). Biochem J 177:903–908

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cook SA, Shiemke AK (2002) Evidence that a type-2 NADH:quinone oxidoreductase mediates electron transfer to particulate methane monooxygenase in Methylococcus capsulatus. Arch Biochem Biophys 398:32−40

    Article  CAS  PubMed  Google Scholar 

  • Csaki R, Bodrossy L, Klem J, Murrell JC, Kovacs K (2003) Genes involved in the copper-dependent regulation of soluble methane monooxygenase of Methylococcus capsulatus (Bath):cloning, sequencing and mutational analysis. Microbiology 149:1785–1795

    Article  CAS  PubMed  Google Scholar 

  • Culpepper MA, Rosenzweig AC (2014) Structure and protein-protein interactions of methanol dehydrogenase from Methylococcus capsulatus (Bath). Biochemistry 53:6211–6219

    Article  CAS  PubMed  Google Scholar 

  • Culpepper MA, Cutsail GE III, Gunderson WA, Hoffman BM, Rosenzweig AC (2014) Identification of the valence and coordination environment of the particulate methane monooxygenase copper centers by advanced EPR characterization. J Am Chem Soc 136:11767–11775

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dassama LMK, Kenney GE, Ro SY, Zielazinski EL, Rosenzweig AC (2016) Methanobactin transport machinery. PNAS 113:13027–13032

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Davidson VL (2004) Electron transfer in quinoproteins. Arch Biochem Biophys 428:32–40

    Article  CAS  PubMed  Google Scholar 

  • Delaney NF, Kaczmarek ME, Ward LM, Swanson PK, Lee MC, Marx CJ (2013) Development of an optimized medium, strain and high-throughput culturing methods for Methylobacterium extorquens. PLoS One 8:e62957

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dennison C, Vijgenboom E, de Vries S, van der Oost J, Canters GW (1995) Introduction of a CuA site into the blue copper protein amicyanin from Thiobacillus versutus. FEBS Lett 365:92–94

    Article  CAS  PubMed  Google Scholar 

  • DiSpirito AA, Semrau JD, Murrell JC, Gallagher WH, Dennison C, Vuilleumier S (2016) Methanobactin and the link between copper and bacterial methane oxidation. Microbiol Mol Biol Rev 80:387–409

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Erb TJ, Berg IA, Brecht V, Müller M, Fuchs G, Alber BE (2007) Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway. Proc Natl Acad Sci USA 104:10631–10636

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Farhan Ul Haque M, Kalidass B, Bandow N, Turpin EA, DiSpirito AA, Semrau JD (2015) Cerium regulates expression of alternative methanol dehydrogenases in Methylosinus trichosporium OB3b. Appl Environ Microbiol 81:217546–217552

    Google Scholar 

  • Fox BG, Liu Y, Dege JE, Lipscomb JD (1991) Complex formation between the protein components of methane monooxygenase from Methylosinus trichosporium OB3b. Identification of sites of component interaction. J Biol Chem 266:540–550

    PubMed  CAS  Google Scholar 

  • Fox BG, Froland WA, Dege JE, Lipscomb JD (1989) Methane monooxygenase from Methylosinus trichosporium OB3b. Purification and properties of a three-component system with high specific activity from a type II methanotroph. J Biol Chem 264:10023–10033

    PubMed  CAS  Google Scholar 

  • Fu Y, Beck DA, Lidstrom ME (2016) Difference in C3–C4 metabolism underlies tradeoff between growth rate and biomass yield in Methylobacterium extorquens AM1. BMC Microbiol 16:156

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Glass JB, Orphan VJ (2012) Trace metal requirements for microbial enzymes involved in the production and consumption of methane and nitrous oxide. Front Microbiol 3:61

    PubMed  PubMed Central  Google Scholar 

  • Good NM, Vu HN, Suriano CJ, Subuyuj GA, Skovran E, Martinez-Gomez NC (2016) Pyrroloquinoline quinone ethanol dehydrogenase in Methylobacterium extorquens AM1 extends lanthanide-dependent metabolism to multicarbon substrates. J Bacteriol 198:3109–3118

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gu W, Farhan Ul Haque M, DiSpirito AA, Semrau JD (2016b) Uptake and effect of rare earth elements on gene expression in Methylosinus trichosporium OB3b. FEMS Microbiol Lett 363. https://doi.org/10.1093/femsle/fnw129

  • Gu W, Farhan Ul Haque M, Baral BS, Turpin EA, Bandow NL, Kremmer E, Flatley A, Zischka H, DiSpirito AA, Semrau JD (2016a) A TonB-dependent transporter is responsible for Methanobactin Uptake by Methylosinus trichosporium OB3b. Appl Environ Microbiol 82:1917–1923

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hakemian AS, Kondapalli KC, Telser J, Hoffman BM, Stemmler TL, Rosenzweig AC (2008) The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b. Biochemistry 47:6793–6801

    Article  CAS  PubMed  Google Scholar 

  • Hanson RS, Hanson TE (1996) Methanotrophic bacteria. Microbiol Rev 60:439–471

    PubMed  PubMed Central  CAS  Google Scholar 

  • Helland R, Fjellbirkeland A, Karlsen OA, Ve T, Lillehaug JR, Jensen HB (2008) An oxidized tryptophan facilitates copper binding in Methylococcus capsulatus-secreted protein MopE. J Biol Chem 283:13897–13904

    Article  CAS  PubMed  Google Scholar 

  • Hibi Y, Asai K, Arafuka H, Hamajima M, Iwama T, Kawai K (2011) Molecular structure of La3+-induced methanol dehydrogenase-like protein in Methylobacterium radiotolerans. J Biosci Bioeng 111:547–549

    Article  CAS  PubMed  Google Scholar 

  • Hu B, Lidstrom ME (2014) Metabolic engineering of Methylobacterium extorquens AM1 for 1-butanol production. Biotechnol Biofuels 7:156

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Itoyama S, Doitomi K, Kamachi T, Shiota Y, Yoshizawa K (2016) Possible peroxo state of the dicopper site of particulate methane monooxygenase from combined quantum mechanics and molecular mechanics calculations. Inorg Chem 55:2771–2277

    Article  CAS  PubMed  Google Scholar 

  • Karlsen OA, Berven FS, Stafford GP, Larsen Ø, Murrell JC, Jensen HB, Fjellbirkeland A (2003) The surface-associated and secreted MopE protein of Methylococcus capsulatus (Bath) responds to changes in the concentration of copper in the growth medium. Appl Environ Microbiol 69:2386–2388

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Keltjens JT, Pol A, Reimann J, Op den Camp HJ (2014) PQQ-dependent methanol dehydrogenases: rare-earth elements make a difference. Appl Microbiol Biotechnol 98:6163–6183

    Article  CAS  PubMed  Google Scholar 

  • Kenney GE, Goering AW, Ross MO, Dehart CJ, Thomas PM, Hoffman BM, Rosenzweig AC (2016) Characterization of Methanobactin from Methylosinus sp. LW4. J Am Chem Soc 138:11124–11127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kenney GE, Rosenzweig AC (2013) Genome mining for methanobactins. BMC Biol 11:17

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kiefer P, Buchhaupt M, Christen P, Kaup B, Schrader J, Vorholt JA (2009) Metabolite profiling uncovers plasmid-induced cobalt limitation under methylotrophic growth conditions. PLoS One 4:e7831

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim HJ, Galeva N, Larive CK, Alterman M, Graham DW (2005) Purification and physical−chemical properties of methanobactin: a chalkophore from Methylosinus trichosporium OB3b. Biochemistry 44:5140–5148

    Article  CAS  PubMed  Google Scholar 

  • Kim HJ, Graham DW, DiSpirito AA, Alterman MA, Galeva N, Larive CK, Asunskis D, Sherwood PM (2004) Methanobactin, a copper-acquisition compound from methane-oxidizing bacteria. Science 305:1612–1615

    Article  CAS  PubMed  Google Scholar 

  • Lankford CE, Byers BR (1973) Bacterial assimilation of iron. Crit Rev Microbiol 2:273–331

    Article  CAS  Google Scholar 

  • Larsen Ø, Karlsen OA (2016) Transcriptomic profiling of Methylococcus capsulatus (Bath) during growth with two different methane monooxygenases. Microbiologyopen 5:254–267

    Article  CAS  PubMed  Google Scholar 

  • Lawton TJ, Rosenzweig AC (2016) Methane-oxidizing enzymes: an upstream problem in biological gas-to-liquids conversion. J AM Chem Soc 138:9327–9340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leak DJ, Dalton H (1986) Growth yields of methanotrophs. A theoretical analysis. Appl Microbiol Biotechnol 23:477–481

    Article  CAS  Google Scholar 

  • Lee SJ, McCormick MS, Lippard SJ, Cho U-S (2013) Control of substrate access to the active site in methane monooxygenase. Nature 494:380–384

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee SW, Keeney DR, Lim DH, DiSpirito AA, Semrau JD (2006) Mixed pollutant degradation by Methylosinus trichosporium OB3b expressing either soluble or particulate methane monooxygenase: can the tortoise beat the hare? Appl Environ Microbiol 72:7503–750910

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee SY, Park HS, Lee Y, Lee SH (2002) Production of chiral and other valuable compounds from microbial polyesters. In: Doi Y, Steinbüchel A (eds) Biopolymers, polyesters, vol 3. Wiley-VCH, Weinheim, pp 375–387

    Google Scholar 

  • Leopoldini M, Russo N, Toscano M (2007) The preferred reaction path for the oxidation of methanol by PQQ containing methanol dehydrogenase: addition–elimination versus hydride-transfer mechanism. Chem Eur 13:2109–2117

    Article  CAS  Google Scholar 

  • Lieberman RL, Rosenzweig AC (2005) Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane. Nature 434:177–182

    Article  CAS  PubMed  Google Scholar 

  • Lim CS, Kampf JW, Pecoraro VL (2009) Establishing the binding affinity of organic carboxylates to 15-metallacrown-5 complexes. Inorg Chem 48:5224–5233

    Article  CAS  PubMed  Google Scholar 

  • Lipscomb JD (1994) Biochemistry of the soluble methane monooxygenase. Annu Rev Microbiol 48:371–399

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Nesheim JC, Lee SK, Lipscomb JD (1995) Gating effects of component B on oxygen activation by the methane monooxygenase hydroxylase component. J Biol Chem 270:24662–24665

    Article  CAS  PubMed  Google Scholar 

  • Maia LB, Moura JJG, Moura I (2015) Molybdenum and tungsten-dependent formate dehydrogenases. J Biol Inorg 20:287–309

    Article  CAS  Google Scholar 

  • Martinez-Gomez NC, Vu HN, Skovran E (2016) Lanthanide chemistry: from coordination in chemical complexes shaping our technology to coordination in enzymes shaping bacterial metabolism. Inorg Chem 55:10083–10089

    Article  CAS  PubMed  Google Scholar 

  • Martinho M, Choi DW, DiSpirito AA, Antholine WE, Semrau JD, Münck E (2007) Mössbauer studies of the membrane-associated methane monooxygenase from Methylococcus capsulatus Bath: evidence for a diiron center. J Am Chem Soc 129:15783–15785

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Matsen JB, Yang S, Stein LY, Beck D, Kalyuzhnaya MG (2013) Global molecular analyses of methane metabolism in Methanotrophic Alphaproteobacterium, Methylosinus trichosporium OB3b. Part I: Transcriptomic study. Front Microbiol 4:40

    Article  PubMed  PubMed Central  Google Scholar 

  • Miethke M, Marahiel MA (2007) Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev 71:413–451

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morton JD, Hayes KF, Semrau JD (2000) Bioavailability of chelated and soil-adsorbed copper to Methylosinus trichosporium OB3b. Environ Sci Technol 34:4917–4922

    Article  CAS  Google Scholar 

  • Müller J, Lugovskoy AA, Wagner G, Lippard SJ (2002) NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase. Biochemistry 41:42–51

    Article  CAS  PubMed  Google Scholar 

  • Murrell JC, McDonald IR, Gilbert B (2000) Regulation of expression of methane monooxygenases by copper ions. Trends Microbiol 8:221–225

    Article  CAS  PubMed  Google Scholar 

  • Myronova N, Kitmitto A, Collins RF, Miyaji A, Dalton H (2006) Three-dimensional structure determination of a protein supercomplex that oxidizes methane to formaldehyde in Methylococcus capsulatus (Bath). Biochemistry 45:11905–11914

    Article  CAS  PubMed  Google Scholar 

  • Nakagawa T, Mitsui R, Tani A, Sasa K, Tashiro S, Iwama T, Hayakawa T, Kawai K (2012) A catalytic role of XoxF1 as La3+-dependent methanol dehydrogenase in Methylobacterium extorquens strain AM1. PLoS One 7:e50480

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nielsen AK, Gerdes K, Murrell JC (1997) Copper-dependent reciprocal transcriptional regulation of methane monooxygenase genes in Methylococcus capsulatus and Methylosinus trichosporium. Mol Microbiol 25:399–409

    Article  CAS  PubMed  Google Scholar 

  • Prejanò M, Marino T, Russo N (2017) How can work methanol dehydrogenase from Methylacidiphilum fumariolicum with the alien Ce(III) ion in the active center? A theoretical study. Chemistry 23:8652–8657

    Article  CAS  PubMed  Google Scholar 

  • Pol A, Barends TR, Dietl A, Khadem AF, Eygensteyn J, Jetten MS, Op den Camp HJ (2014) Rare earth metals are essential for methanotrophic life in volcanic mudpots. Environ Microbiol 16:255–264

    Article  CAS  PubMed  Google Scholar 

  • Richardson DJ, Edwards MJ, White GF, Baiden N, Hartshorne RS, Fredrickson JK et al (2012) Exploring the biochemistry at the extracellular redox frontier of bacterial mineral Fe (III) respiration. Biochem Soc Trans 40:493–500

    Article  CAS  PubMed  Google Scholar 

  • Rosenzweig AC, Brandstetter H, Whittington DA, Nordlund P, Lippard SJ, Frederick CA (1997) Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions. Protein Struct Funct Genet 29:141–152

    Article  CAS  Google Scholar 

  • Sazinsky MH, Lippard SJ (2015) Methane monooxygenase: functionalizing methane at iron and copper. Met Ions Life Sci 15:205–256

    PubMed  CAS  Google Scholar 

  • Schmidt S, Christen P, Kiefer P, Vorholt JA (2010) Functional investigation of methanol dehydrogenase-like protein XoxF in Methylobacterium extorquens AM1. Microbiology 156:2575–2586

    Article  CAS  PubMed  Google Scholar 

  • Semrau JD, Jagadevan S, DiSpirito AA, Khalifa A, Scanlan J, Bergman BH, Freemeier BC, Baral BS, Bandow NL, Vorobev A, Haft DH, Vuilleumier S, Murrell JC (2013) Methanobactin and MmoD work in concert to act as the ‘copper-switch’ in methanotrophs. Environ Microbiol 15:3077–3086

    CAS  PubMed  Google Scholar 

  • Semrau JD (2011) Bioremediation via methanotrophy: overview of recent findings and suggestions for future research. Front Microbiol 2:209

    Article  PubMed  PubMed Central  Google Scholar 

  • Semrau JD, DiSpirito AA, Yoon S (2010) Methanotrophs and copper. FEMS 34:496–531

    CAS  Google Scholar 

  • Shiemke AK, Arp DJ, Sayavedra-Soto LA (2004) Inhibition of membrane-bound methane monooxygenase and ammonia monooxygenase by diphenyliodonium: implications for electron transfer. J Bacteriol 186:928–937

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shiota Y, Juhász G, Yoshizawa K (2013) Role of tyrosine residue in methane activation at the dicopper site of particulate methane monooxygenase: a density functional theory study. Inorg Chem 52:7907–7917

    Article  CAS  PubMed  Google Scholar 

  • Shiota Y, Yoshizawa K (2009) Comparison of the reactivity of bis(mu-oxo)CuIICuIII and CuIIICuIII species to methane. Inorg Chem 48:838–845

    Article  CAS  PubMed  Google Scholar 

  • Sirajuddin S, Rosenzweig AC (2015) Enzymatic oxidation of methane. Biochemistry 54:2283–2294

    Article  CAS  PubMed  Google Scholar 

  • Sonntag F, Buchhaupt M, Schrader J (2014) Thioesterases for ethylmalonyl-CoA pathway derived dicarboxylic acid production in Methylobacterium extorquens AM1. Appl Microbiol Biotechnol 98:4533–4544

    Article  CAS  PubMed  Google Scholar 

  • Stafford GP, Scanlan J, McDonald IR, Murrell JC (2003) rpoN, mmoR and mmoG, genes involved in the expression of soluble methane monooxygenase in Methylosinus trichosporium OB3b. Microbiology 149:1771–1784

    Article  CAS  PubMed  Google Scholar 

  • Tonge GM, Harrison DEF, Knowles CJ, Higgins IJ (1975) Properties and partial purification of the methane-oxidizing enzyme system from Methylosinus trichosporium. FEBS Lett 58:293–299

    Article  CAS  PubMed  Google Scholar 

  • Vorobev A, Beck DA, Kalyuzhnaya MG, Lidstrom ME, Chistoserdova L (2013) Comparative transcriptomics in three Methylophilaceae species uncover different strategies for environmental adaptation. Peer J 1:e115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vu HN, Subuyuj GA, Vijayakumar S, Good NM, Martinez-Gomez NC, Skovran E (2016) Lanthanide-dependent regulation of methanol oxidation systems in Methylobacterium extorquens AM1 and their contribution to methanol growth. J Bacteriol 198:1250–1259

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang W, Liang AD, Lippard SJ (2015) Coupling oxygen consumption with hydrocarbon oxidation in bacterial multicomponent monooxygenases. Acc Chem Res 48:2632–2639

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang W, Lippard SJ (2014) Diiron oxidation state control of substrate access to the active site of soluble methane monooxygenase mediated by the regulatory component. J Am Chem Soc 136:2244–2247

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Watkins JD, Bocarsly AB (2014) Direct reduction of carbon dioxide to formate in high-gas-capacity ionic liquids at post-transition-metal electrodes. ChemSusChem 7:284–290

    Article  CAS  PubMed  Google Scholar 

  • Werpy T, Petersen G (2004) Top value added chemicals from biomass: Volume I. Results of screening for potential candidates from sugars and synthesis gas other information Medium: ED; Size: 76 pp

    Google Scholar 

  • Yoon S, DiSpirito AA, Kraemer SM, Semarau JD (2010) A simple assay for screening microorganisms for Chalkophore production. Environ Microbiol Rep 2:295–303

    Article  CAS  PubMed  Google Scholar 

  • Yoshizawa K, Shiota Y (2006) Conversion of methane to methanol at the mononuclear and dinuclear copper sites of Particulate Methane Monooxygenase (pMMO): a DFT and QM/MM study. J Am Chem Soc 128:9873–9881

    Article  CAS  PubMed  Google Scholar 

  • Zahn JA, DiSpirito AA (1996) Membrane-associated methane monooxygenase from Methylococcus capsulatus (Bath). J Bacteriol 178:1018–1029

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Michigan State University, East Lansing, MI, USA

    Norma Cecilia Martinez-Gomez

  2. San Jose State University, San Jose, CA, USA

    Elizabeth Skovran

Authors
  1. Norma Cecilia Martinez-Gomez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elizabeth Skovran
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Norma Cecilia Martinez-Gomez .

Editor information

Editors and Affiliations

  1. Department of Biology, San Diego State University, San Diego, California, USA

    Marina G. Kalyuzhnaya

  2. Department of Chemical Engineering, Tsinghua University, Beijing, China

    Xin-Hui Xing

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Martinez-Gomez, N.C., Skovran, E. (2018). Metals in Methanotrophy. In: Kalyuzhnaya, M., Xing, XH. (eds) Methane Biocatalysis: Paving the Way to Sustainability. Springer, Cham. https://doi.org/10.1007/978-3-319-74866-5_5

Download citation

Publish with us

Policies and ethics

Search

Navigation