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Recurrent Respiratory Papillomatosis and Human Papillomavirus

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Infections of the Ears, Nose, Throat, and Sinuses

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Abstract

Recurrent respiratory papillomatosis (RRP) is a disease that is characterized by recurrent growth of exophytic wart-like lesions throughout the respiratory tract. The disease is mainly associated with low-risk human papillomavirus (HPV) types 6 and 11. The distribution of the age of onset of RRP shows three peaks: age 4 years old, age 34, and age 60–64. Patients with RRP generally experience voice problems and without treatment, eventually develop a compromised airway. Owing to the recurrent character of RRP, most patients require repeated surgical interventions to remove the lesions to keep the voice functional and the airway patent. There is currently no cure for RRP. This chapter reviews the etiology, diagnosis, therapeutic options, and prevention of RRP.

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Acknowledgement

Note: this chapter is partly based on work done for the PhD theses of Dr. R.E.A. Tjon Pian Gi (Recurrent respiratory papillomatosis—from diagnosis to treatment. Rijksuniversiteit Groningen, the Netherlands, defended October 12, 2016) and Dr. M.R.M. San Giorgi (Recurrent Respiratory Papillomatosis—clinical course and psychosocial aspects. Rijksuniversiteit Groningen, the Netherlands, defended July 5, 2017).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Frederik G. Dikkers

  2. Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Robin E. A. Tjon Pian Gi & Michel R. M. San Giorgi

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  1. Frederik G. Dikkers
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  2. Robin E. A. Tjon Pian Gi
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  3. Michel R. M. San Giorgi
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Correspondence to Frederik G. Dikkers .

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  1. Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Marlene L. Durand

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA

    Daniel G. Deschler

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Dikkers, F.G., Tjon Pian Gi, R.E.A., San Giorgi, M.R.M. (2018). Recurrent Respiratory Papillomatosis and Human Papillomavirus. In: Durand, M., Deschler, D. (eds) Infections of the Ears, Nose, Throat, and Sinuses. Springer, Cham. https://doi.org/10.1007/978-3-319-74835-1_29

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