Advances in Genetic Engineering for Higher Production and Quality Improvement of Food and Beverages

  • Aly Farag El Sheikha
Part of the Food Microbiology and Food Safety book series (FMFS)


Genetic engineering promises to bring important and rapid leaps in food production. It will affect all steps of the production chain, from farm to final food processing. As a biotechnological practice, it has the potential to be used as an effective tool to address the various problems in food and society. Nowadays, our production-to-consumption food system is complex, and consumer needs are growing toward food which is safe, nutritious, abundant, diverse, and less costly. Therefore, scientific and technological advancements must be accelerated and applied in developed and developing countries alike if we are to feed a growing world population. This chapter deals with an analytical perspective on the food applications of genetic engineering that made possible the modern production-to-consumption food system capable of feeding nearly seven billion people, and it also discusses the benefits of this promising biotechnological tool to enhance the food supply in terms of quantity and quality even further and to increase the health and wellness of the growing global population. However, as with any new technology, careful consideration of the effects of employing these tools is necessary to ensure that the result will be a net benefit to humanity. Recent controversies about genetically engineered foods have highlighted the need to allay consumer fears by applying the reliable techniques of traceability and also providing more experimental evidence and sound scientific judgment to assess the risks versus benefits.


Genetic engineering (GE) Genetically modified foods (GMFs) GE benefits, GE potential risks Feeding worldwide, Traceability, PCR-based techniques 


  1. Adenle AA (2011) Response to issues on GM agriculture in Africa: are transgenic crops safe. BMC Res Notes 4:1–6CrossRefGoogle Scholar
  2. Aggarwal S (2012) What’s fueling the biotech engine – 2011 to 2012. Nat Biotechnol 30(12):1191–1197CrossRefGoogle Scholar
  3. Akoh CC, Chang SW, Lee GC, Shaw JF (2008) Biocatalysis for the production of industrial products and functional foods from rice and other agricultural produce. J Agric Food Chem 56(22):10445–10451CrossRefGoogle Scholar
  4. Ask M, Mapelli V, Höck H, Olsson L, Bettiga M (2013) Engineering glutathione biosynthesis of Saccharomyces cerevisiae increases robustness to inhibitors in pretreated lignocellulosic materials. Microb Cell Factories 12:87CrossRefGoogle Scholar
  5. Barre P, Vezinhet F, Dequin S, Blondin B (1993) Genetic improvement of wine yeasts. In: Fleet GH (ed) Wine microbiology and biotechnology. Harwood Academic Publishers, ChurGoogle Scholar
  6. Baulcombe DD, Jones J, Pickett J, Puigdomenech JP (2014) GM science update: a report to the council for science and technology. March 2013. Accessed 20 Feb 2018
  7. Belhaj K, Chaparro-Garcia A, Kamoun S, Patron NJ, Nekrasov V (2015) Editing plant genomes with CRISPR/Cas9. Curr Opin Biotechnol 32:76–78CrossRefGoogle Scholar
  8. Benbrook CM (2012) Impacts of genetically engineered crops on pesticide use in the U.S. – the first sixteen years. Environ Sci Eur 24:24. Accessed 20 Feb 2018CrossRefGoogle Scholar
  9. Bonciani T, Solieri L, De Vero L, Giudici P (2016) Improved wine yeasts by direct mating and selection under stressful fermentative conditions. Eur Food Res Technol 242(6):899–910CrossRefGoogle Scholar
  10. Bonfini L, Kay S, Heinze P, Van den Eede G (2002) Report on GMO detection identification and quantification methods submitted to collaborative studies. European Communities, EUR 20383 EN:1–29Google Scholar
  11. Brookes G, Barfoot P (2014) Economic impact of GM crops: the global income and production effects 1996–2012. GM Crops Food 5(1):65–75CrossRefGoogle Scholar
  12. Buchholz K, Kasche K, Bornscheuer UT (2005) Biocatalysts and enzyme technology. WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimGoogle Scholar
  13. Buiatti M, Christou P, Pastore G (2013) The application of GMOs in agriculture and in food production for a better nutrition: two different scientific points of view. Genes Nutr 8:255–270CrossRefGoogle Scholar
  14. Chitchumroonchokchai C, Diretto G, Parisi B, Giuliano G, Failla ML (2017) Potential of golden potatoes to improve vitamin A and vitamin E status in developing countries. PLoS One 12(11):e0187102CrossRefGoogle Scholar
  15. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F (2013) Multiplex genome engineering using CRISPR/Cas systems. Science 339(6121):819–823CrossRefGoogle Scholar
  16. Consolidated Regulations of Canada (CRC) (2017) Food and drug regulations. Food and Drug Act, C.R.C., c. 870, Regulations are current to October 25, 2017 and last amended on June 20, 2017.,_c._870.pdf. Accessed 20 Feb 2018
  17. Datta A (2013) Genetic engineering for improving quality and productivity of crops. Agric Food Secur 2:15. Accessed 20 Feb 2018CrossRefGoogle Scholar
  18. De Vero L, Solieri L, Giudici P (2011) Evolution-based strategy to generate non-genetically modified organisms Saccharomyces cerevisiae strains impaired in sulfate assimilation pathway. Lett Appl Microbiol 53:572–575CrossRefGoogle Scholar
  19. De Vero L, Bonciani T, Verspohl A, Mezzetti F, Giudici P (2017) High-glutathione producing yeasts obtained by genetic improvement strategies: a focus on adaptive evolution approaches for novel wine strains. AIMS Microbiol 3(2):155–170CrossRefGoogle Scholar
  20. DeMayo FJ, Spencer TE (2014) CRISPR bacon: a sizzling technique to generate genetically engineered pigs. Biol Reprod 91(3):79CrossRefGoogle Scholar
  21. Dequin S (2001) The potential of genetic engineering for improving brewing, wine-making and baking yeasts. Appl Microbiol Biotechnol 56:577–588CrossRefGoogle Scholar
  22. Diehl P (2017) What are GMOs and how are they made? Accessed 20 Feb 2018
  23. Duncan WS, Jamieson DJ (1996) Glutathione is an important antioxidant molecule in the yeast Saccharomyces cerevisiae. FEMS Microbiol Lett 141:207–212Google Scholar
  24. El Sheikha AF, Mokhtar NFK, Amie C, Lamasudin DU, Isa NM, Mustafa S (2017) Authentication technologies using DNA-based approaches for meats and halal meats determination. Food Biotechnol 31(4):281–315Google Scholar
  25. El Sheikha AF (2018a) How to determine the geographical origin of food by molecular techniques? In: El Sheikha AF, Levin RE, Xu J (eds) Molecular techniques in food biology: safety, biotechnology, authenticity & traceability. Wiley, OxfordCrossRefGoogle Scholar
  26. El Sheikha AF (2018b) Revolution in fermented foods: from artisan household technology to era of biotechnology. In: El Sheikha AF, Levin RE, Xu J (eds) Molecular techniques in food biology: safety, biotechnology, authenticity & traceability. Wiley, OxfordCrossRefGoogle Scholar
  27. Ellstrand NPH, Hancock JF (1999) Gene flow and introgression from domesticated plants into their wild relatives. Annu Rev Ecol Syst 30:539–563CrossRefGoogle Scholar
  28. European Commission (2000) Directive 2000/13/EC of the European Parliament and of the Council of 20 March 2000 on the approximation of the laws of the Member States relating to the labelling, presentation and advertising of foodstuffs. 6.5.2000. Official Journal of the European Communities: L 109/29–42. Accessed 20 Feb 2018
  29. European Commission (2003a) Regulation (EC) No 1829/2003 of the European Parliament and of the Council of 22 September 2003 on genetically modified food and feed. 18.10.2003. Official Journal of the European Union: L 268/1–23. Accessed 20 Feb 2018
  30. European Commission (2003b) Regulation (EC) No 1830/2003 of the European Parliament and of the Council of 22 September 2003 concerning the traceability and labelling of genetically modified organisms and the traceability of food and feed products produced from genetically modified organisms and amending Directive 2001/18/EC. 18.10.2003. Official Journal of the European Union: L 268/24–28. Accessed 20 Feb 2018
  31. European Commission (2004) Commission Regulation (EC) No 641/2004 of 6 April 2004 on detailed rules for the implementation of Regulation (EC) No 1829/2003 of the European Parliament and of the Council as regards the application for the authorisation of new genetically modified food and feed, the notification of existing products and adventitious or technically unavoidable presence of genetically modified material which has benefited from a favourable risk evaluation.7.4.2004. Official Journal of the European Union: L 102/14–25. Accessed 20 Feb 2018
  32. European Food Information Council (EUFIC) (2006) Modern biotechnology in food: applications of food biotechnology: enzymes, September 6, 2006. Accessed 20 Feb 2018
  33. European Union Regulations (2013) Genetically Modified Foodstuffs Regulations 2013, Statutory Instruments (S.I. No. 268 of 2013). Accessed 20 Feb 2018
  34. Falk MC, Chassy BM, Harlander SK, Hoban TJ IV, McGloughlin MN, Akhlaghi AR (2002) Food biotechnology: benefits and concerns. J Nutr 132:1384–1390CrossRefGoogle Scholar
  35. FAO (Food and Agricultural Organization of the United Nations) (2009) Feeding the world, eradicating hunger. World summit on food security. Food and Agricultural Organization of the United Nations, Rome. WSFS 2009/INF/2Google Scholar
  36. Farmer BH (1986) Perspectives on the ‘Green Revolution’ in South Asia. Mod Asian Stud 20(1):175–199CrossRefGoogle Scholar
  37. FDA (2015) Genetically engineered animals: consumer Q&A, August 12, 2015. Accessed 20 Feb 2018
  38. FDA (2017) Foods derived from plants produced using genome editing. April 12, 2017. Accessed 20 Feb 2018
  39. Food Safety Authority of Ireland (FSAI) (2005) GM food survey 2004, Food labelled with “GM free” type declarations. Accessed 20 Feb 2018
  40. Forge F (1999) Recombinant bovine somatotropin (rbST). ParliamentaryResearch Branch, CanadaGoogle Scholar
  41. Ghosh S, Meli VS, Kumar A, Thakur A, Chakraborty N, Chakraborty S, Datta A (2011) The N-glycan processing enzymes alpha-mannosidase and beta-D-N-acetylhexosaminidase are involved in ripening-associated softening in the non-climacteric fruits of capsicum. J Exp Bot 62(2):571–582CrossRefGoogle Scholar
  42. Giudici P, Zinnato A (1983) Influenza dell’uso di mutanti nutrizionali sulla produzione di alcooli superiori. Vignevini 10:63–65. [In Italian]Google Scholar
  43. Giuseppe E, Monica S, GianFranco G (2010) Science for food safety, security and quality: a review – part 1. Qual Life 1(1):26–40Google Scholar
  44. Godfray HCJ, Beddington JR, Crute IR, Haddad L, Lawrence D, Muir JF, Pretty J, Robinson S, Thomas SM, Toulmin C (2010) Food security: the challenge of feeding 9 billion people. Science 327(5967):812–818CrossRefGoogle Scholar
  45. Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996) Life with 6000 genes. Science 274(5287):546–567CrossRefGoogle Scholar
  46. GRACE Communications Foundation (2017) Genetic engineering, Food Program. Accessed 20 Feb 2018
  47. Grujić S, Blesić M (2007) Food regulations. Faculty of Technology, Banja LukaGoogle Scholar
  48. Gura T (1999) New genes boost rice nutrients. Science 285:994–995CrossRefGoogle Scholar
  49. Habibi-Najafi MB (2006) Food biotechnology and its impact on our food supply. Glob J Biotechnol Biochem 1(1):22–27Google Scholar
  50. Hare PD, Chua NH (2002) Excision of selectable marker genes from transgenic plants. Nat Biotechnol 20(6):575–580CrossRefGoogle Scholar
  51. Haroon F, Ghazanfar M (2016) Applications of food biotechnology. J Ecosyst Ecography 6(4):215. Accessed 20 Feb 2018
  52. Hatti-Kaul R (2009) Enzyme production. Biotechnology, Vol. V. Encyclopedia of Life Support Systems (EOLSS). p 1–7. Accessed 02 Feb 2015
  53. Hesham EA (2010) Genetic improvement of yeast for bioethanol fermentation, Presented to Genetics Department, Faculty of Agriculture Assiut University. Accessed 02 Feb 2015
  54. Holst-Jensen A (2009) Testing for genetically modified organisms (GMOs): past, present and future perspectives. Biotechnol Adv 27(6):1071–1082CrossRefGoogle Scholar
  55. Hsieh Y-HP, Ofori JA (2007) Innovations in food technology for health. Asia Pac J Clin Nutr 16(Suppl 1):65–73PubMedGoogle Scholar
  56. Hua W, El Sheikha AF, Xu J (2018) Molecular techniques for making recombinant enzymes used in food processing. In: El Sheikha AF, Levin RE, Xu J (eds) Molecular techniques in food biology: safety, biotechnology, authenticity & traceability. Wiley, OxfordGoogle Scholar
  57. Institute of Medicine and National Research Council (2004) Safety of genetically engineered foods: approaches to assessing unintended health effects. The National Academies Press, Washington, DC. Accessed 20 Feb 2018
  58. International Food Information Council Foundation (IFIC) (2013) Food biotechnology: a communicator’s guide to improving understanding. 3rd edn. April 16, 2013. Accessed 20 Feb 2018
  59. International Food Information Council Foundation (IFIC) (2014) IFIC 2014 food technology survey: consumers support food biotechnology’s use for certain benefits. July 10, 2014. Accessed 20 Feb 2018
  60. International Food Information Council Foundation (IFIC) (2015) Food & health survey 2015, the 2015 food & health survey was conducted by Greenwald & Associates of Washington D.C., March 13–26, 2015. Accessed 20 Feb 2018
  61. International Service for the Acquisition of Agri-biotech Applications (ISAAA) (2016) Global status of commercialized biotech/GM crops: 2016, ISAAA Brief No. 52. ISAAA, Ithaca. Accessed 20 Feb 2018
  62. Irfan M, Datta A (2017) Improving food nutritional quality and productivity through genetic engineering. Int J Cell Sci Mol Biol 2(1):555576. Accessed 20 Feb 2018
  63. Ishige T, Honda K, Shimizu S (2005) Whole organism biocatalysis. Curr Opin Chem Biol 9:174–180CrossRefGoogle Scholar
  64. James C (2013) Global status of commercialized biotech/GM crops: 2013, ISAAA Brief No. 46, 2013Google Scholar
  65. Jha A (2011) GM chickens created that could prevent the spread of bird flu, the guardian. January 13, 2011. Accessed 20 Feb 2018
  66. Kirk O, Borchert TV, Fuglsang CC (2002) Industrial enzyme applications. Curr Opin Biotechnol 13(4):345–351CrossRefGoogle Scholar
  67. Lawrence R (1988) New applications of biotechnology in the food industry. Biotechnology and the food supply: proceedings of symposiumGoogle Scholar
  68. Li Y, Wei G, Chen J (2004) Glutathione: a review on biotechnological production. Appl Microbiol Biotechnol 66:233–242CrossRefGoogle Scholar
  69. Li S, Yang X, Yang S, Zhu M, Wang X (2012) Technology prospecting on enzyme: application, marketing, and engineering. Comput Struct Biotechnol J 2(3):e201209017CrossRefGoogle Scholar
  70. Lievens A, Petrillo M, Querci M, Patak A (2015) Genetically modified animals: options and issues for traceability and enforcement. Trends Food Sci Technol 44(2):159–176CrossRefGoogle Scholar
  71. Losey JE, Rayor LS, Carter ME (1999) Transgenic pollen harms monarch larvae. Nature 399:214CrossRefGoogle Scholar
  72. McBryde C, Gardner JM, De Barros LM, Jiranek V (2006) Generation of novel wine yeast strains by adaptive evolution. Am J Enol Vitic 57(4):423–430Google Scholar
  73. Meli VS, Ghosh S, Prabha TN, Chakraborty N, Chakraborty S, Datta A (2010) Enhancement of fruit shelf life by suppressing N-glycan processing enzymes. Proc Natl Acad Sci U S A 107(6):2413–2418CrossRefGoogle Scholar
  74. Mendoza A, Fernández S, Cruz MA, Rodríguez-Perez MA, Resendez-Perez D, Barrera Saldaña HA (2006) Detection of genetically modified maize food products by the polymerase chain reaction. Cienc Tecnol Aliment 5(3):175–181CrossRefGoogle Scholar
  75. Mendoza-Cózatl D, Loza-Tavera H, Hernández-Navarro A, Moreno-Sánchez R (2005) Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants. FEMS Microbiol Rev 29:653–671CrossRefGoogle Scholar
  76. Mlalazi B, Welsch R, Namanya P, Khanna H, Geijskes RJ, Harrison MD, Harding R, Dale JL, Bateson M (2012) Isolation and functional characterization of banana phytoene synthase genes as potential cisgenes. Planta 236(5):1585–1598CrossRefGoogle Scholar
  77. Mortimer RK (2000) Evolution and variation of the yeast (Saccharomyces) genome. Genome Res 10:403–409CrossRefGoogle Scholar
  78. Nicolia A, Manzo A, Veronesi F, Rosellini D (2014) An overview of the last 10years of genetically engineered crop safety research. Crit Rev Biotechnol 34(1):77–88CrossRefGoogle Scholar
  79. Nodari RO, Guerra MP (2003) Plantas transgênicas e seus produtos: impactos, riscos e segurança alimentar. Rev Nutr 16:105–116CrossRefGoogle Scholar
  80. Ortiz DF, Kreppel L, Speiser DM, Scheel G, McDonald G, Ow DW (1992) Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. EMBO J 11:3491–3499PubMedPubMedCentralGoogle Scholar
  81. Panzarini NH, Matos EASDA, Wosiack PA, Bittencourt JVM (2015) Biotechnology in agriculture: the perception of farmers on the inclusion of Genetically Modified Organisms (GMOs) in agricultural production. Afr J Agric Res 10(7):631–636CrossRefGoogle Scholar
  82. Park A (2015) 7 things you need to know about GMO salmon, time. November 19, 2015. Accessed 20 Feb 2018
  83. Patel R (2013) The long green revolution. J Peasant Stud 40(1):1–63CrossRefGoogle Scholar
  84. Perez-Gago MB, Serra M, del Rıo MA (2006) Color change of fresh-cut apples coated with whey protein concentrate-based edible coatings. Postharvest Biol Technol 39:84–92CrossRefGoogle Scholar
  85. Pretorius IS (2000) Tailoring wine yeast for the new millennium: novel approaches to the ancient art of winemaking. Yeast 16:675–729CrossRefGoogle Scholar
  86. Qiu Z, Deng Z, Tan H, Zhou S, Cao L (2015) Engineering the robustness of Saccharomyces cerevisiae by introducing bifunctional glutathione synthase gene. J Ind Microbiol Biotechnol 42:537–542CrossRefGoogle Scholar
  87. R.S.C., 1985, c. F-27 (2017) An act respecting food, drugs, cosmetics and therapeutic devices, Published by the Minister of Justice, Last amended on June 22, 2017. Accessed 20 Feb 2018
  88. Rai MK, Shekhawat NS (2014) Recent advances in genetic engineering for improvement of fruit crops. Plant Cell Tissue Organ Cult 116(1):1–15CrossRefGoogle Scholar
  89. Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F (2013) Genome engineering using the CRISPR-Cas9 system. Nat Protoc 8(11):2281–2308CrossRefGoogle Scholar
  90. Reichman JR, Watrud LS, Lee EH, Burdick CA, Bollman MA, Storm MJ, King GA, Mallory-Smith C (2006) Establishment of transgenic herbicide-resistant creeping bentgrass (Agrostis stolonifera L.) in nonagronomic habitats. Mol Ecol 15(13):4243–4255CrossRefGoogle Scholar
  91. Richt JA, Kasinathan P, Hamir AN, Castilla J, Sathiyaseelan T, Vargas F, Sathiyaseelan J, Wu H, Matsushita H, Koster J, Kato S, Ishida I, Soto C, Robl JM, Kuroiwa Y (2007) Production of cattle lacking prion protein. Nat Biotechnol 25(1):132. Accessed 20 Feb 2018CrossRefGoogle Scholar
  92. Rous CV, Snow R, Kunkee RE (1983) Reduction of higher alcohols by fermentation with a leucine-auxotrophic mutant of wine yeast. J Inst Brew 89:274–278CrossRefGoogle Scholar
  93. Sahlin P (1999) Fermentation as a method of food processing (production of organic acids, pH-development and microbial growth in fermenting cereals) Licentiate thesis May, Lund UniversityGoogle Scholar
  94. Sauer U (2001) Evolutionary engineering of industrially important microbial phenotypes. In: Nielsen J, Eggeling L, Dynesen J, Gárdonyi M, Gill RT, de Graaf AA, Hahn-Hägerdal B, Jönsson LJ, Khosla C, Licari R, McDaniel R, McIntyre M, Miiller C, Nielsen J, Cordero Otero RR, Sahm H, Sauer U, Stafford DE, Stephanopoulos G, Wahlbom CE, Yanagimachi KS, van Zyl WH (eds) Metabolic engineering. Springer, BerlinGoogle Scholar
  95. Schafer MG, Ross AA, Londo JP, Burdick CA, Lee EH, Travers SE, Van de Water PK, Sagers CL (2011) The establishment of genetically engineered canola populations in the US. PLoS One 6(10):e25736CrossRefGoogle Scholar
  96. Schreiber GA (1999) Challenges for methods to detect genetically modified DNA in foods. Food Control 10:351–352CrossRefGoogle Scholar
  97. Secretariat of the Convention on Biological Diversity (2000) Cartagena protocol on biosafety to the convention on biological diversity: text and annexes. Secretariat of the Convention on Biological Diversity, Montreal. Accessed 20 Feb 2018
  98. Sipiczki M (2011) Diversity, variability and fast adaptive evolution of the wine yeast (Saccharomyces cerevisiae) genome—a review. Ann Microbiol 61:85–93CrossRefGoogle Scholar
  99. Slack JMW (2014) Genes: a very short introduction. Oxford University Press, New YorkGoogle Scholar
  100. Solieri L, Verspohl A, Bonciani T, Caggia C, Giudici P (2015) Fast method for identifying inter- and intraspecies Saccharomyces hybrids in extensive genetic improvement programs based on yeast breeding. J Appl Microbiol 119:149–161CrossRefGoogle Scholar
  101. Sun SS (2008) Applications of agricultural biotechnology to improve food nutrition and health care products. Asia Pac J Clin Nutr 17:87–90PubMedGoogle Scholar
  102. Tietyen JL, Garrison ME, Bessin RT Hildebrand DF (2000a) Food biotechnology, educational programs of the Kentucky Cooperative Extension Service. Accessed 20 Feb 2018
  103. Tietyen JL, Garrison ME, Bessin RT Hildebrand DF (2000b) Food biotechnology teaching guide, educational programs of the Kentucky Cooperative Extension Service. Accessed 20 Feb 2018
  104. Ting J, Xu R, Xu J (2018) Molecular identification and distribution of yeasts in fruits. In: El Sheikha AF, Levin RE, Xu J (eds) Molecular techniques in food biology: safety, biotechnology, authenticity & traceability. Wiley, OxfordGoogle Scholar
  105. Turanli-Yildiz B, Alkim C, Cakar ZP (2012) Protein engineering methods and applications. In: Kaumaya P (ed) Protein engineering, InTech, Rijeka. Accessed 20 Feb 2018Google Scholar
  106. Verspohl A, Solieri L, Giudici P (2017) Exploration of genetic and phenotypic diversity within Saccharomyces uvarum for driving strain improvement in winemaking. Appl Microbiol Biotechnol 101:2507–2521CrossRefGoogle Scholar
  107. Visk D (2017) CRISPR applications in plants, a report from the plant and animal genomics conference. Genetic Engineering & Biotechnology News (GEN), February 14, 2017. Accessed 20 Feb 2018
  108. WHO (2014) Frequently asked questions on genetically modified foods, food safety. Accessed 20 Feb 2018
  109. WHO (2017) Food, genetically modified, health topics. Accessed 20 Feb 2018
  110. WHO (World Health Organization) (2000) Nutrition for health and development: a global agenda for combating malnutrition. World Health Organization, GenevaGoogle Scholar
  111. Ye X, Al-Babili S, Kloti A, Zhang J, Lucca P, Beyer P, Potrykus I (2000) Engineering the provitamin A (β -carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287(5451):303–305CrossRefGoogle Scholar
  112. Zechmann B, Liou LC, Koffler BE, Horvat L, Tomašić A, Fulgosi H, Zhang Z (2011) Subcellular distribution of glutathione and its dynamic changes under oxidative stress in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 11:631–642CrossRefGoogle Scholar
  113. Zel J, Milavec M, Morisset D, Plan D, Van den Eede G, Gruden K (2012) How to reliably test for GMOs. Springer, LondonCrossRefGoogle Scholar
  114. Zhang C, Wohlhueter R, Zhang H (2016) Genetically modified foods: a critical review of their promise and problems. Food Sci Human Wellness 5:116–123CrossRefGoogle Scholar
  115. Zhao Y, McDaniel M (2005) Sensory quality of foods associated with edible film and coating systems and shelf-life extension. In: Han JH (ed) Innovations in food packaging. Elsevier Academic Press, San DiegoGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Aly Farag El Sheikha
    • 1
    • 2
  1. 1.Department of BiologyMcMaster UniversityHamiltonCanada
  2. 2.Department of Food Science and Technology, Faculty of AgricultureMinufiya University, Minufiya GovernmentShibin El KomEgypt

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