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Impact of Heavy Metal Carcinogens on Human Health

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Biomedical Applications of Metals

Abstract

During the development of human activities, it has been noticed that such activities contribute to the discharge of toxic chemicals like metals and metalloids into the atmosphere. These toxic metals are accumulated in the dietary articles of human beings. Food chain polluted with toxic metals and metalloids is a significant path of human exposure and thus may cause a number of hazardous effects on human health. Nevertheless, cancer is a leading cause of morbidity, mortality, and premature death worldwide. Certain approaches like less exposure to carcinogenic factors can reduce the risk of most cancer types in human. Epigenetic variations in the etiology of cancer have led to increasing of cancer research studies in the recent years. Although epigenetic effects of these elements have more prominent role than their genetic effects, these elements are able to alter the pattern of cancer-related genes’ expression profiles. Hence, an understanding of the principal epigenetically mechanisms of these trace elements and the compounds that could reduce their toxicities or the number of cancer cases is necessary. Conceivably, the toxic effects of these elements in many regions are anticipated but antioxidant supplements may eradicate the reactive oxygen species as foremost effects of these elements. In this chapter, we tried to focus on various studies dealing with epigenetic effects of carcinogens on human health.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Department of Biotechnology, IFTM University, Delhi Road (NH 24), Moradabad, 244102, Uttar Pradesh, India

    Sanjay Mishra & Amit Kumar Mani Tiwari

  2. Department of Biochemistry, King George’s Medical University, Lucknow, 226003, Uttar Pradesh, India

    Abbas Ali Mahdi

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  1. Sanjay Mishra
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  2. Amit Kumar Mani Tiwari
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  3. Abbas Ali Mahdi
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Correspondence to Sanjay Mishra .

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Editors and Affiliations

  1. Nanobiotechnology Laboratory, Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. Nanobiotechnology Laboratory, Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Avinash P. Ingle

  3. Departmento Di Chimica Farmacia, University of Sassari, Sassari, Italy

    Serenella Medici

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Mishra, S., Tiwari, A.K.M., Mahdi, A.A. (2018). Impact of Heavy Metal Carcinogens on Human Health. In: Rai, M., Ingle, A., Medici, S. (eds) Biomedical Applications of Metals. Springer, Cham. https://doi.org/10.1007/978-3-319-74814-6_13

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