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Design, Fabrication, and Testing of a Constant-Force Microinjector

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Abstract

This chapter presents the design and testing of a flexure-based microinjector with constant force output dedicated to biological cell micromanipulation. The microinjector offers a constant force without adopting a force controller. The motion control is sufficient to provide a constant output force, that simplifies the system design procedure. The injector is actuated by a piezoelectric actuator via a displacement amplifier. Analytical models of the mechanism are established and verified by conducting simulation study with finite element analysis (FEA) . A prototype device is fabricated by 3D printing process for experimental study. The feasibility of the developed constant-force injector for biological cell micromanipulation is verified by experimental studies.

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References

  1. Chen, G., Gou, Y., Zhang, A.: Synthesis of compliant multistable mechanisms through use of a single bistable mechanism. J. Mech. Des. 133(8), 081007 (2011)

    Article  Google Scholar 

  2. Chen, Y.H., Lan, C.C.: An adjustable constant-force mechanism for adaptive end-effector operations. J. Mech. Des. 134(3), 031005 (2012)

    Article  Google Scholar 

  3. Choi, K.B., Kim, D.H.: Monolithic parallel linear compliant mechanism for two axes ultraprecision linear motion. Rev. Sci. Instrum. 77(6), 065106 (2006)

    Article  Google Scholar 

  4. Choi, Y.J., Sreenivasan, S., Choi, B.J.: Kinematic design of large displacement precision xy positioning stage by using cross strip flexure joints and over-constrained mechanism. Mech. Mach. Theory 43(6), 724–737 (2008)

    Article  MATH  Google Scholar 

  5. Goncalves, F.D., Finnegan, P.F., Sigman, G., Brown, M.V.: Caster wheel with constant force mechanism (2015). US Patent 20,150,274,495

    Google Scholar 

  6. Gu, G.Y., Zhu, L.M., Su, C.Y., Ding, H., Fatikow, S.: Modeling and control of piezo-actuated nanopositioning stages: a survey. IEEE Trans. Autom. Sci. Eng. 13(1), 313–332 (2016)

    Article  Google Scholar 

  7. Holst, G.L., Teichert, G.H., Jensen, B.D.: Modeling and experiments of buckling modes and deflection of fixed-guided beams in compliant mechanisms. J. Mech. Des. 133(5), 051 (2011)

    Article  Google Scholar 

  8. Howell, L.L.: Compliant Mechanisms. Wiley, New York (2001)

    Google Scholar 

  9. Klein, R.J.: Constant force compression tool (2013). US Patent App. 13/746,929

    Google Scholar 

  10. Lamers, A.J., Sanchez, J.A.G., Herder, J.L.: Design of a statically balanced fully compliant grasper. Mech. Mach. Theory 92, 230–239 (2015)

    Article  Google Scholar 

  11. Lan, C.C., Cheng, Y.J.: Distributed shape optimization of compliant mechanisms using intrinsic functions. J. Mech. Des. 130(7), 072304 (2008)

    Article  Google Scholar 

  12. Liu, Y., Shan, J., Gabbert, U.: Feedback/feedforward control of hysteresis-compensated piezoelectric actuators for high-speed scanning applications. Smart Mater. Struct. 24(1), 015012 (2015)

    Article  Google Scholar 

  13. Liu, Y., Zhang, Y., Xu, Q.: Design and control of a novel compliant constant-force gripper based on buckled fixed-guided beams. IEEE/ASME Trans. Mechatron. 22(1), 476–486 (2017)

    Article  Google Scholar 

  14. Malloy, A.L., Radzik, J., Dean, M., Hauver, B.C., Knaus, G.A., Thomas, C.: Constant force coaxial cable connector (2012). US Patent RE43,832

    Google Scholar 

  15. Polit, S., Dong, J.: Design of high-bandwidth high-precision flexure-based nanopositioning modules. J. Manuf. Syst. 28(2), 71–77 (2009)

    Article  Google Scholar 

  16. Putra, A.S., Huang, S., Tan, K.K., Panda, S.K., Lee, T.H.: Design, modeling, and control of piezoelectric actuators for intracytoplasmic sperm injection. IEEE Trans. Control Syst. Technol. 15(5), 879–890 (2007)

    Article  Google Scholar 

  17. Qiu, J., Lang, J.H., Slocum, A.H.: A curved-beam bistable mechanism. J. Microelectromech. Syst. 13(2), 137–146 (2004)

    Article  Google Scholar 

  18. Todd, B., Jensen, B.D., Schultz, S.M., Hawkins, A.R.: Design and testing of a thin-flexure bistable mechanism suitable for stamping from metal sheets. J. Mech. Des. 132(7), 071011 (2010)

    Article  Google Scholar 

  19. Wang, J.Y., Lan, C.C.: A constant-force compliant gripper for handling objects of various sizes. J. Mech. Des. 136(7), 071008 (2014)

    Article  Google Scholar 

  20. Wang, P., Xu, Q.: Design and testing of a flexure-based constant-force stage for biological cell micromanipulation. IEEE Trans. Autom. Sci. Eng. (2017). https://doi.org/10.1109/TASE.2017.2733553

  21. Wang, P., Xu, Q.: Design of a flexure-based constant-force XY precision positioning stage. Mech. Mach. Theory 108, 1–13 (2017)

    Article  Google Scholar 

  22. Xie, Y., Sun, D., Tse, H.Y.G., Liu, C., Cheng, S.H.: Force sensing and manipulation strategy in robot-assisted microinjection on zebrafish embryos. IEEE/ASME Trans. Mechatron. 16(6), 1002–1010 (2011)

    Article  Google Scholar 

  23. Xu, Q.: Adaptive discrete-time sliding mode impedance control of a piezoelectric microgripper. IEEE Trans. Rob. 29(3), 663–673 (2013)

    Article  Google Scholar 

  24. Xu, Q., Li, Y.: Analytical modeling, optimization and testing of a compound bridge-type compliant displacement amplifier. Mech. Mach. Theory 46(2), 183–200 (2011)

    Article  MATH  Google Scholar 

  25. Zhang, W., Sobolevski, A., Li, B., Rao, Y., Liu, X.: An automated force-controlled robotic micromanipulation system for mechanotransduction studies of drosophila larvae. IEEE Trans. Autom. Sci. Eng. 13(2), 789–797 (2016)

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Electromechanical Engineering, University of Macau, Macau, China

    Qingsong Xu

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  1. Qingsong Xu
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Correspondence to Qingsong Xu .

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Xu, Q. (2018). Design, Fabrication, and Testing of a Constant-Force Microinjector. In: Micromachines for Biological Micromanipulation. Springer, Cham. https://doi.org/10.1007/978-3-319-74621-0_5

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  • DOI: https://doi.org/10.1007/978-3-319-74621-0_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-74620-3

  • Online ISBN: 978-3-319-74621-0

  • eBook Packages: EngineeringEngineering (R0)

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