Abstract
Space agencies conduct radiation research because astronauts are exposed to chronic doses of radiation. But during long duration missions beyond LEO there is a real danger that crews may be exposed to acute doses that may lead to acute radiation syndrome (ARS). To be prepared for such missions, space agencies must be prepared to anticipate radiation exposures and be able to deal with the consequences [1–4]. One way to do this is to implement a radiation medical countermeasures (Figs. 9.1 and 9.2) program that would cover products used following a radiological emergency.
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References
Anno GH, Baum SJ, Withers HR, Young RW. Symptomatology of acute radiation effects in humans after exposure to doses of 0.5-30 Gy. Health Phys. 1989;56(6):821–38.
Waselenko JK, MacVittie TJ, Blakely WF, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med. 2004;140:1037–51.
Townsend LW. Implications of the space radiation environment for human exploration in deep space. Radiat Prot Dosim. 2005;115:44–50.
Cucinotta FA, Schimmerling W, Wilson JW, Peterson LE, Badhwar GD, Saganti PB, Dicello JF. Space radiation cancer risks and uncertainties for Mars missions. Radiat Res. 2001;156:682–8.
Slupphaug G, Kavli B, Krokan HE. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res. 2003;531(1-2):231–51.
Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 2010;79:181–211.
Booth C, Tudor G, Tudor J, Katz BP, MacVittie TJ. Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys. 2012;103(4):383–99.
Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol. 2002;30(6):513–28.
Kouvaris JR, Kouloulias VE, Vlahos LJ. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007;12(6):738–47.
van der Vijgh WJ, Peters GJ. Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects. Semin Oncol. 1994;21(5 Suppl 11):2–7.
Bourhis J, Blanchard P, Maillard E, Brizel DM, Movsas B, Buentzel J, et al. Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data. J Clin Oncol. 2011;29(18):2590–7.
Praetorius NP, Mandal TK. Alternate delivery route for amifostine as a radio-/chemo-protecting agent. J Pharm Pharmacol. 2008;60(7):809–15.
Seed TM, Inal CE, Singh VK. Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis. Int J Radiat Biol. 2014;90(7):594–604.
Verdrengh M, Jonsson IM, Holmdahl R, Tarkowski A. Genistein as an anti-inflammatory agent. Inflamm Res. 2003;52(8):341–6. 8
Landauer MR, Srinivasan V, Seed TM. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol. 2003;23(6):379–85.
Para AE, Bezjak A, Yeung IW, Van Dyk J, Hill RP. Effects of genistein following fractionated lung irradiation in mice. Radiother Oncol. 2009;92(3):500–10.
Grace MB, Blakely WF, Landauer MR. Genistein-induced alterations of radiation-responsive gene expression. Radiat Meas. 2007;42:1152–7.
Ha CT, Li XH, Fu D, Xiao M, Landauer MR. Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation. Radiat Res. 2013;180(3):316–25.
Davis TA, Landauer MR, Mog SR, Barshishat-Kupper M, Zins SR, Amare MF, et al. Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Exp Hematol. 2010;38(4):270–81.
Moulder JE, Cohen EP, Fish BL, Hill P. Prophylaxis of bone marrow transplant nephropathy with captopril, an inhibitor of angiotensin-converting enzyme. Radiat Res. 1993;136(3):404–7.
Patil R, Szabó E, Fells JI, Balogh A, Lim KG, Fujiwara Y, Tigyi GJ. Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by a novel LPA2 receptor-specific non-lipid agonist. Chem Biol. 2015;22(2):206–16.
Wan XS, Ware JH, Zhou Z, Donahue JJ, Kennedy AR. Protection against radiation induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents. Int J Radiat Oncol Biol Phys. 2006;64:1475–81.
Guan J, Wan XS, Zhou Z, Ware JH, Donahue JJ, Biaglow JE, Kennedy AR. The effects of dietary supplement agents on space radiation-induced oxidative stress in Sprague-Dawley rats. Radiat Res. 2004;162:572–9.
Guan J, Stewart J, Ware JH, Zhou Z, Donahue JJ, Kennedy AR. Effects of dietary supplements on the space radiation-induced reduction in total antioxidant status in CBA mice. Radiat Res. 2006;165:373–8.
Ware JH, Sanzari J, Avery S, et al. Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice. Radiat Res. 2010;174:325–30.
Romero-Weaver AL, Wan XS, Diffenderfer ES, et al. Kinetics of neutrophils in mice exposed to radiation and/or granulocyte colony-stimulating factor treatment. Radiat Res. 2013;180:177–88.
Molineux G. The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). Curr Pharm Des. 2004;10(11):1235–44.
Scholz M, Ackermann M, Emmrich F, Loeffler M, Kamprad M. Effectiveness of cytopenia prophylaxis for different filgrastim and pegfilgrastim schedules in a chemotherapy mouse model. Biologics. 2009;3:27–37.
Fazzi R, Orciuolo E, Trombi L, Mattii L, Battola B, Riccioni R, et al. PEG-Filgrastim activity on granulocyte functions. Leuk Res. 2007;31(10):1453–5.
Kaur I, Simons ER, Castro VA, Mark Ott C, Pierson DL. Changes in neutrophil functions in astronauts. Brain Behav Immun. 2005;19(6):547–54.
Smith SM, Davis-Street JE, Rice BL, Nillen JL, Gillman PL, Block G. Nutritional status assessment in semiclosed environments: ground-based and space flight studies in humans. J Nutr. 2001;131:2053–61.
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Seedhouse, E. (2018). Pharmacological Countermeasures. In: Space Radiation and Astronaut Safety. SpringerBriefs in Space Development. Springer, Cham. https://doi.org/10.1007/978-3-319-74615-9_9
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