Abstract
Metastatic lesions to the temporal bone are relatively rare in clinical practice, but the temporal bone is often involved by metastatic disease in autopsy studies. The most common site for metastatic involvement is the petrous portion of the temporal bone. Breast, lung, prostate, melanoma, kidney, and stomach cancers are the most likely primary tumors to produce temporal bone metastases. Hearing loss, otorrhea, vertigo, and facial paralysis are the most common symptoms of temporal bone metastasis; however, a large proportion of metastatic lesions to the temporal bone are asymptomatic. In the patient with a history of malignant disease, the differential diagnosis should include metastasis when patients present with otologic complaints. Diagnostic imaging with CT and MRI, especially when combined with PET/CT or whole-body bone scan, usually leads to the diagnosis. Surgical resection of metastatic disease in the temporal bone is typically not warranted because temporal bone metastases are usually a sign of widespread metastatic disease.
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References
Bakhos D, Chenebaux M, Lescanne E, Lauvin M-A, Cormier B, Robier A. Two cases of temporal bone metastases as presenting sign of lung cancer. Eur Ann Otorhinolaryngol Head Neck Dis. 2012;129(1):54–7.
Yoda S, Cureoglu S, Paparella MM. Pulmonary carcinoma metastasis to the internal auditory canal. Otol Neurotol. 2011;32(6):e48.
Streitmann MJ, Sismanis A. Metastatic carcinoma of the temporal bone. Am J Otol. 1996;17(5):780–3.
Lan M-Y, Shiao A-S, Li W-Y. Facial paralysis caused by metastasis of breast carcinoma to the temporal bone. J Chin Med Assoc. 2004;67(11):587–90.
Gloria-Cruz TI, Schachern PA, Paparella MM, Adams GL, Fulton SE. Metastases to temporal bones from primary nonsystemic malignant neoplasms. Arch Otolaryngol Head Neck Surg. 2000;126(2):209–14.
Maddox HE 3rd. Metastatic tumors of the temporal bone. Ann Otol Rhinol Laryngol. 1967;76(1):149–65.
Schuknecht HF, Allam AF, Murakami Y. Pathology of secondary malignant tumors of the temporal bone. Ann Otol Rhinol Laryngol. 1968;77(1):5–22.
Berlinger NT, Koutroupas S, Adams G, Maisel R. Patterns of involvement of the temporal bone in metastatic and systemic malignancy. Laryngoscope. 1980;90:619–27.
Deroee AF, Joglekar S, Paparella MM. Malignant melanoma metastasis to temporal bone. Otol Neurotol. 2009;30(2):248–9.
Proctor B, Lindsay JR. Tumors involving the petrous pyramid of the temporal bone. Arch Otolaryngol. 1947;46:180–94.
Nelson EG, Hinojosa R. Histopathology of metastatic temporal bone tumors. Arch Otolaryngol Head Neck Surg. 1991;117(2):189–93.
Laigle-Donadey F, Taillibert S, Martin-Duverneuil N, Hildebrand J, Delattre J-Y. Skull-base metastases. J Neurooncol. 2005;75(1):63–9.
Faucett EA, Richins H, Khan R, Jacob A. Metastatic prostate cancer to the left temporal bone: a case report and review of the literature. Case Rep Otolaryngol. 2015;2015:250312.
Kedjanyi WK, Bath AP, Ball RY, Hosni AA, Wickstead M. Metastatic adenocarcinoma of the temporal bone. J Laryngol Otol. 1994;108(8):710–2.
Wu C, Kaga K, Ohira Y, Suzuki J. Histopathology of multiple temporal bone metastasis from pancreatic adenocarcinoma: a case showing bilateral hearing loss and Bechterew's phenomenon. Otolaryngol Head Neck Surg. 2000;122(4):613–5.
Hoshino T, Hiraide F, Nomura Y. Metastatic tumour of the inner ear: a histopathological report. J Laryngol Otol. 1972;86(7):697–707.
Kumagami H. Cases of malignant lymphosarcoma metastasizing into the temporal bone. Jibiinkoka. 1971;43(8):579–82.
Janczewski G, Fujita S. Metastasis of prostatic adenocarcinoma to the temporal bone. Otolaryngol Pol. 1972;26(1):81–5.
Sienkiewicz H, Berezowski S. Neoplastic metastases to the temporal bone. Otolaryngol Pol. 1974;28(5):585–90.
Katsarkas A, Seemayer TA. Bilateral temporal bone metastases of a uterine cervix carcinoma. J Otolaryngol. 1976;5(4):315–8.
Sasaki J, Katoh N, Ishida M, Yoshida H, Mori S, Satoh M, et al. A case of thyroid carcinoma with temporal bone metastasis. Gan No Rinsho. 1984;30(2):162–6.
Ohira Y, Kaga K, Kodama A. A case of bilateral sudden hearing loss and vertigo caused by bilateral temporal bone metastasis from pancreatic carcinoma—comparison of clinical findings and temporal bone pathological findings. Nippon Jibiinkoka Gakkai Kaiho. 1991;94(1):9–15.
Yildirim-Baylan M, Erdogmus N, Cureoglu S, Paparella MM. Bladder cancer metastases to the temporal bone. Otol Neurotol. 2011;32(5):e40–e1.
Hill BA, Kohut RI. Metastatic adenocarcinoma of the temporal bone. Arch Otolaryngol. 1976;102(9):568–71.
Adams GL, Paparella MM, el-Fiky FM. Primary and metastatic tumors of the temporal bone. Laryngoscope. 1971;81(8):1273–85.
Jahn AF, Farkashidy J, Berman JM. Metastatic tumors in the temporal bone—a pathophysiologic study. J Otolaryngol. 1979;8(1):85–95.
Saito H, Chinzei K, Furuta M. Pathological features of peripheral facial paralysis caused by malignant tumour. Acta Otolaryngol Suppl. 1988;446:165–71.
Robbins SL, editor. Pathology. 4th ed. Philadelphia: WB Saunders; 1972.
Cumberworth V, Friedmann I, Glover G. Late metastasis of breast carcinoma to the external auditory canal. J Laryngol Otol. 1994;108(09):808–10.
Kobayashi K, Igarashi M, Ohashi K, McBride RA. Metastatic seminoma of the temporal bone. Arch Otolaryngol Head Neck Surg. 1986;112(1):102–5.
Grubbe Gregersen K, Hansen S. Metastasis to the temporal bone may cause acute peripheral vestibular syndrome and impaired hearing. Ugeskr Laeger. 2013;175(22):1576–7.
Sahin AA, Ro JY, Ordonez NG, Luna MA, Weber RS, Ayala AG. Temporal bone involvement by prostatic adenocarcinoma: report of two cases and review of the literature. Head Neck. 1991;13(4):349–54.
Dogan E, Erdag TK, Sarioglu S, Guneri EA. Metastatic adenocarcinomas of the temporal bone: a report of three cases. Kulak Burun Bogaz Ihtis Derg. 2011;21(5):285–9.
Vize G. Laryngeal metastasis to the temporal bone causing facial paralysis. J Laryngol Otol. 1974;88(2):175–7.
Nakamura M, Kaga K, Ohira Y. Metastatic hypopharyngeal carcinoma to the temporal bone. Eur Arch Otorhinolaryngol. 1996;253(3):185–8.
Pfleiderer AG, Molyneux AJ, Tee MK. Metastatic spread of osteosarcoma to the temporal bone in a patient with Paget's disease: a case report. J Otolaryngol. 1992;21(2):112–4.
Thirunavukarasu V, Carter T, Dezso A, Holland C. Post-aural ache: an unusual presentation of a metastatic temporal bone lesion from a primary adenocarcinoma of the lung. J Laryngol Otol. 2013;127(10):1017–9.
Djeric D, Boricic I, Tomanovic N, Cvorovic L, Blazic S, Folic M, et al. The facial palsy as first symptom of the temporal bone lung cancer metastasis. Braz J Otorhinolaryngol. 2017;83(6):720–2.
Yang JI, Kang JM, Byun HJ, Chung GE, Yim JY, Park MJ, et al. Metastatic hepatocellular carcinoma presenting as facial nerve palsy and facial pain. Korean J Hepatol. 2011;17(4):319–22.
Yasumatsu R, Okura K, Sakiyama Y, Nakamuta M, Matsumura T, Uehara S, et al. Metastatic hepatocellular carcinoma of the external auditory canal. World J Gastroenterol. 2007;13(47):6436–8.
Nagai M, Yamada H, Kitamoto M, Ikeda J, Mori Y, Monzen Y, et al. Facial nerve palsy due to temporal bone metastasis from hepatocellular carcinoma. J Gastroenterol Hepatol. 2005;20(7):1131–2.
Bergstrom LV, Baker BB, Sando I. Sudden deafness and facial palsy from metastatic bronchogenic carcinoma. J Laryngol Otol. 1977;91(9):787–93.
Choi SH, Park IS, Kim YB, Hong SM. Unusual presentation of a metastatic tumor to the temporal bone: severe otalgia and facial paralysis. Korean J Audiol. 2014;18(1):34–7.
Teschner M, Durisin M, Mangold A, Lenarz T, Stover T. Peripheral facial palsy as the first symptom of a metastatic bronchogenic carcinoma. Laryngorhinootologie. 2006;85(7):512–6.
Kitajiri M, Sando I, Takahara T, Klau M. Metastatic squamous cell carcinoma in the neck invading the facial canal—a case report. Auris Nasus Larynx. 1984;11(3):171–6.
Weiss MD, Kattah JC, Jones R, Manz HJ. Isolated facial nerve palsy from metastasis to the temporal bone: report of two cases and a review of the literature. Am J Clin Oncol. 1997;20(1):19–23.
Garcia-Garcia P, Laguna-del-Estal P, Gonzalez-Lois C, Brea-Alvarez B. Facial paralysis secondary to single metastasis to the temporal bone from bladder cancer. Acta Otorrinolaringol Esp. 2015;66(2):122–3.
Mitsuya K, Nakasu Y, Horiguchi S, Harada H, Nishimura T, Yuen S, et al. Metastatic skull tumors: MRI features and a new conventional classification. J Neurooncol. 2011;104(1):239–45.
O'Sullivan JM, Norman AR, McNair H, Dearnaley DP. Cranial nerve palsies in metastatic prostate cancer—results of base of skull radiotherapy. Radiother Oncol. 2004;70(1):87–90.
Hugh SC, Enepekides D, Wong J, Yeung R, Lin VY. Metastasis of follicular variant of papillary thyroid carcinoma masquerading as primary temporal bone tumour. J Laryngol Otol. 2011;125(5):528–32.
Suryanarayanan R, Dezso A, Ramsden RT, Gillespie JE. Metastatic carcinoma mimicking a facial nerve schwannoma: the role of computerized tomography in diagnosis. J Laryngol Otol. 2005;119(12):1010–2.
Cureoglu S, Tulunay O, Ferlito A, Schachern PA, Paparella MM, Rinaldo A. Otologic manifestations of metastatic tumors to the temporal bone. Acta Otolaryngol. 2004;124(10):1117–23.
Razek AA, Huang BY. Lesions of the petrous apex: classification and findings at CT and MR imaging. Radiographics. 2012;32(1):151–73.
Tsunoda A, Tanaka Y, Sato T, Kirimura S, Kitamura K. Vertigo by breast cancer metastasis 33 years after treatment. Intern Med. 2016;55(3):311–3.
Vasileiadis I, Kapetanakis S, Vasileiadis D, Petousis A, Karatzas T. External auditory canal mass as the first manifestation of a bronchogenic carcinoma: report of a rare case. Ann Otol Rhinol Laryngol. 2013;122(6):378–81.
Saldanha CB, Bennett JD, Evans JN, Pambakian H. Metastasis to the temporal bone, secondary to carcinoma of the bladder. J Laryngol Otol. 1989;103(6):599–601.
Hain M, Feldberg E, Halperin D. Case report: metastatic small-cell lung carcinoma of the external auditory canal. Ear Nose Throat J. 2012;91(11):476–8.
Wu ZS, Li SC, Ho HC, Tseng JE, Lin YH, Su YC. Metastatic hepatocellular carcinoma in the tympanic membrane. Jpn J Clin Oncol. 2011;41(2):272–4.
Khan I, Mohamad S, Shakeel M, Jaramillo MJ. Aural metastasis from a nasal malignant melanoma: case report with literature review. J Laryngol Otol. 2011;125(12):1290–3.
Merrick Y. Metastatic colon adenocarcinoma of the middle ear. Arch Otorhinolaryngol. 1983;238(2):103–5.
Feinmesser R, Libson Y, Uziely B, Gay I. Metastatic carcinoma to the temporal bone. Am J Otol. 1986;7(2):119–20.
Barnes L. Metastases to the head and neck: an overview. Head Neck Pathol. 2009;3(3):217–24.
Chapman PR, Shah R, Curé JK, Bag AK. Petrous apex lesions: pictorial review. Am J Roentgenol. 2011;196(3_Suppl):WS26–37.
Brackmann DE, Bartels LJ. Rare tumors of the cerebellopontine angle. Otolaryngol Head Neck Surg. 1980;88(5):555–9.
Hariharan S, Zhu J, Nadkarni MA, Donahue JE. Metastatic lung cancer in the cerebellopontine angles mimicking bilateral acoustic neuroma. J Clin Neurosci. 2005;12(2):184–6.
Della Puppa A, Rossetto M, Berti F, Zustovich F, Manara R, Gardiman MP, et al. Internal auditory canal metastasis. J Neurosurg Sci. 2010;54(4):159–62.
Nazim K, Mehmet Y, Tuna ED, Marlen MA. Bilateral internal acoustic canal mass. J Craniofac Surg. 2013;24(5):1863.
Ziegler EA, Bohl J, Maurer J. Bilateral progressive hearing loss as the first manifestation of metastatic carcinoma of the head of the pancreas. Case report. Laryngorhinootologie. 2001;80(8):436–8.
Yang AS, Bird P. Intracranial metastatic melanoma presenting with bilateral hearing loss. Otol Neurotol. 2009;30(2):243–4.
Gerganov VM, Hore N, Herold C, Wrede K, Stan AC, Samii A, et al. Bilateral malignant melanoma metastases to the internal auditory canal/cerebellopontine angle: surgical management and preservation of function. J Neurosurg. 2008;108(4):803–7.
De Vos C, Gerard JM, Decat M, Gersdorff M. Metastatic renal cell carcinoma to the temporal bone: case report. B-ENT. 2005;1(1):43–6.
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Gidley, P.W., Nader, ME. (2018). Metastatic Lesions to the Temporal Bone. In: Gidley, P., DeMonte, F. (eds) Temporal Bone Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-74539-8_15
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