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Exosomes Function in Tumor Immune Microenvironment

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Exosomes, Stem Cells and MicroRNA

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1056))

Abstract

Immune cells and mesenchymal stem/stromal cells are the major cellular components in tumor microenvironment that actively migrate to tumor sites by sensing “signals” released from tumor cells. Together with other stromal cells, they form the soil for malignant cell progression. In the crosstalk between tumor cells and its surrounded microenvironment, exosomes exert multiple functions in shaping tumor immune responses. In tumor cells, their exosomes can lead to pro-tumor immune responses, whereas in immune cells, their derived exosomes can operate on tumor cells and regulate their ability to growth, metastasis, even reaction to chemotherapy. Employing exosomes as vehicles for the delivery products to initiate anti-tumor immune responses has striking therapeutic effects on tumor progression. Thus, exosomes are potential therapeutic targets in tumor-related clinical conditions. Here we discuss the role of exosomes in regulating tumor immune microenvironment and future indications for the clinical application of exosomes.

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Authors and Affiliations

  1. Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    Yin Huang, Keli Liu, Qing Li, Yikun Yao & Ying Wang

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  1. Yin Huang
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  2. Keli Liu
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  3. Qing Li
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  4. Yikun Yao
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  5. Ying Wang
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Correspondence to Ying Wang .

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Editors and Affiliations

  1. Cellastra Inc., San Francisco, California, USA

    Karl L. Mettinger

  2. Rutgers New Jersey Medical School, Newark, New Jersey, USA

    Pranela Rameshwar

  3. Novartis Pharmaceutical Corp., East Hanover, New Jersey, USA

    Vinod Kumar

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Huang, Y., Liu, K., Li, Q., Yao, Y., Wang, Y. (2018). Exosomes Function in Tumor Immune Microenvironment. In: Mettinger, K., Rameshwar, P., Kumar, V. (eds) Exosomes, Stem Cells and MicroRNA. Advances in Experimental Medicine and Biology, vol 1056. Springer, Cham. https://doi.org/10.1007/978-3-319-74470-4_7

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