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Adenomatous Polyposis Syndromes: MUTYH-Associated Polyposis

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Hereditary Colorectal Cancer

Abstract

MUTYH-associated polyposis was first described in 2002. It is inherited recessively, and patients usually develop between tens and hundreds of adenomas throughout life. The risk of developing colon cancer when surveillance is not started in time is very high. In this chapter the clinical aspects, cancer risk, mutation spectrum, risk for heterozygotes and tumour characteristics will be described.

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Authors and Affiliations

  1. Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands

    Maartje Nielsen

  2. Institute of Human Genetics, Center for Hereditary Tumor Syndromes, University of Bonn, Bonn, Germany

    Stephan Aretz

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  1. Maartje Nielsen
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  2. Stephan Aretz
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Correspondence to Maartje Nielsen .

Editor information

Editors and Affiliations

  1. Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de Llobregat, Barcelona, Spain

    Laura Valle

  2. University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California, USA

    Stephen B. Gruber

  3. Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de Llobregat, Barcelona, Spain

    Gabriel Capellá

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Nielsen, M., Aretz, S. (2018). Adenomatous Polyposis Syndromes: MUTYH-Associated Polyposis. In: Valle, L., Gruber, S., Capellá, G. (eds) Hereditary Colorectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-74259-5_9

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