Adenomatous Polyposis Syndromes: Introduction

Chapter

Abstract

The adenomatous polyposis of the colorectum is the most frequent polyposis type and a precancerous condition with a high lifetime risk of colorectal cancer (CRC), unless detected early. Currently, at least five different inherited forms can be delineated by molecular genetic analyses. Although all types are defined by multiple adenomas which result in a similar diagnostic and therapeutic approach, a significant clinical variability in terms of number and age at onset and the presence of benign and malignant extraintestinal lesions can be observed.

Keywords

Polyposis coli FAP Gastrointestinal polyposis 

References

  1. 1.
    Clark JC, Collan Y, Eide TJ, Esteve J, Ewen S, Gibbs NM, Jensen OM, Koskela E, MacLennan R, Simpson JG, et al. Prevalence of polyps in an autopsy series from areas with varying incidence of large-bowel cancer. Int J Cancer. 1985;36:179–86.CrossRefGoogle Scholar
  2. 2.
    Rex DK, Lehman GA, Ulbright TM, Smith JJ, Pound DC, Hawes RH, Helper DJ, Wiersema MJ, Langefeld CD, Li W. Colonic neoplasia in asymptomatic persons with negative fecal occult blood tests: influence of age, gender, and family history. Am J Gastroenterol. 1993;88:825–31.PubMedGoogle Scholar
  3. 3.
    Tomlinson I, Jaeger E, Leedham S, Thomas H. The classification of intestinal polyposis. Nat Genet. 2013;45(1):2.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Human Genetics, Center for Hereditary Tumor Syndromes, University of BonnBonnGermany

Personalised recommendations