Abstract
Type 2 diabetes, once considered a disease restricted to adults, has increased in prevalence in childhood, largely due to the obesity epidemic in youth. This disease represents a serious public health issue as it is associated with significant comorbidities and complications even when compared with adults with the same disease and children with type 1 diabetes. Presently, metformin and insulin are the only two medications approved for use in children and little is known about the prevention of type 2 diabetes in youth. There is an urgent need for a better understanding of the underlying biology of the disease in youth and for the development of effective preventative and therapeutic strategies.
Keywords
Type 2 diabetes Obesity Insulin resistance Lifestyle intervention Metformin InsulinNotes
Acknowledgments
Modified from previous edition version by Cosimo Giannini M.D., Ph.D. and Sonia Caprio M.D.
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