Weighted Composite Binary Endpoint

Abstract

A variety of weighted effect measures and analysis approaches for composite endpoints were proposed in the literature of which only a few are applicable to composite binary endpoints (Pocock et al., Eur Heart J 33:176–182, 2012; Buyse, Stat Med 29:3245–3257, 2010). Many of these approaches should be applied with care as explored in more detail in Chap. 14. Therefore, in this chapter, an alternative weighted effect measure for a composite binary endpoint will be introduced. As motivated above, an intuitive way to define a weighted effect measure is to extend the standard unweighted effect measure in a reasonable way. For a binary endpoint, the common effect measure is the absolute risk difference. In the remainder of this chapter, a weighted version of this risk difference will be introduced.