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Molecular and Cellular Biology of the Right Heart

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Right Heart Pathology

Abstract

The present chapter attempts a detailed yet comprehensive account of the exceedingly complex molecular events involved in heart development, including description of the main differentiation signaling pathways, transcription factors, enhancers and gene regulatory networks, with a special emphasis on applying this continuously enlarging body of modern scientific knowledge to the field of stem cell differentiation into cardiomyocytes for diagnostic and therapeutic applications. MicroRNAs are also emerging as an important area of discovery aiming to revolutionize current therapies in cardiology, therefore we describe their involvement in cardiogenesis, proliferation/apoptosis, angiogenesis, fibrosis and hypertrophy. After reviewing the architectural organization, ultrastructure details and functional compartments of cardiomyocytes derived from in vitro and in vivo studies, we focus on molecular mechanisms involved in cardiac hypertrophy and fibrosis, particularly on calcium signaling events triggering these excessive adaptive responses. Further, we stress the embryogenetic and molecular differences between the right and left ventricle, as well as their pathophysiology specificities and clinical consequences.

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Acknowledgements

BA expresses his gratitude to Prof. Andrei Dumitru Iacobas for directing his early career in scientific research, and to Prof. Kanigula Mubagwa for introduction in the field of cardiac electrophysiology. This study was funded from Competitiveness Operational Programme 2014–2020 project P_37_675 (contract no. 146/2016), Priority Axis 1, Action 1.1.4, co-financed by the European Funds for Regional Development and Romanian Government funds. The content of this publication does not necessarily reflect the official position of the European Union or Romanian Government.

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  1. Department of Biophysics and Physiology, Department of Biology, University of Bucharest, Bucharest, Romania

    Bogdan Amuzescu

  2. Department of Cellular Therapies and Regenerative Medicine, “N. Simionescu” Institute of Cell Biology and Pathology, Bucharest, Romania

    Horia Maniu

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  1. Bogdan Amuzescu
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  2. Horia Maniu
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Correspondence to Bogdan Amuzescu .

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  1. Department of Medicine, Titu Maiorescu University, Bucharest, Romania

    Silviu Ionel Dumitrescu

  2. Department of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Ion C. Ţintoiu

  3. Department of Surgery, Chinese University of Hong Kong, Sha Tin, Hong Kong

    Malcolm John Underwood

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Amuzescu, B., Maniu, H. (2018). Molecular and Cellular Biology of the Right Heart. In: Dumitrescu, S., Ţintoiu, I., Underwood, M. (eds) Right Heart Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-73764-5_3

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