Effects of Fluids on the Macro- and Microcirculations
Intravenous fluid administration is one of the most frequently performed interventions in the intensive care unit (ICU) and in hospital in general. In fact, most inpatients will receive fluids at some point during their hospital stay . In critically ill patients, fluid resuscitation is a vital component of patient management. It has been shown that both too little and too much fluid can be detrimental. A positive cumulative fluid balance on day four of a critical care admission has been associated with increased morbidity [2, 3]. Both perioperatively and during sepsis, a U‐shaped curve has been described for volume of fluid administered and morbidity. Higher mortality is observed at both extremes of volume of fluid given [4, 5].
However, despite extensive research in the field, controversy remains regarding the best approach to fluid therapy. The FENICE study focused on the fluid challenge and found wide disparity in practice; from fluid choice to method of...
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