Persistent Inflammation, Immunosuppression and Catabolism after Severe Injury or Infection

  • P. A. Efron
  • F. A. Moore
  • S. C. Brakenridge
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


Starting in the 1990s, reports describing chronic critical illness emerged under a variety of descriptive terms including the “neuropathy of critical illness”, “myopathy of critical illness”, “intensive care unit (ICU)-acquired weakness” and most recently “post-ICU syndrome”. These reports largely originated from medical ICUs that included individuals with a wide variety of admission diagnoses, most common of which was acute exacerbation of chronic disease. These patients required prolonged mechanical ventilation and were often discharged to long‐term care facilities. Given the clinical heterogeneity of this patient population, the underlying pathophysiology of chronic critical illness has remained ill‐defined. However, with recent improved implementation of evidence‐based ICU care, the epidemiology of multiple organ failure (MOF) has evolved. Early hospital mortality has decreased substantially and the incidence of late onset MOF deaths in the ICU has...


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • P. A. Efron
    • 1
  • F. A. Moore
    • 1
  • S. C. Brakenridge
    • 1
  1. 1.Departments of Surgery and the Sepsis and Critical Illness Research CenterUniversity of Florida College of MedicineGainesvilleUSA

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