Skip to main content

Early Detection of Acute Kidney Injury after Cardiac Surgery: A Problem Solved?

  • Chapter
Annual Update in Intensive Care and Emergency Medicine 2018

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Hu J, Chen R, Liu S, Xu X, Zou J, Ding X (2016) Global incidence and outcomes of adult patients with acute kidney injury after cardiac surgery: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth 30:82–89

    Article  Google Scholar 

  2. Siddiqui NF, Coca SG, Devereaux PJ et al (2012) Secular trends in acute dialysis after elective major surgery 1995 to 2009. CMAJ 184:1237–1245

    Article  PubMed  Google Scholar 

  3. Dégano IR, Salomaa V, Veronesi G et al (2015) Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations. Heart 101:1413–1421

    Article  Google Scholar 

  4. Soares DM, Pessanha JF, Sharma A, Brocca A, Ronco C (2017) Delayed nephrology consultation and high mortality on acute kidney injury: a meta-analysis. Blood Purif 43:57–67

    Article  PubMed  Google Scholar 

  5. Lombi F, Muryan A, Canzonieri R, Trimarchi H (2016) Biomarkers in acute kidney injury: evidence or paradigm? Nefrologia 36:339–346

    Article  Google Scholar 

  6. Vandenberghe W, De Loor J, Hoste EAJ (2017) Diagnosis of cardiac-surgery associated acute kidney injury from functional to damage biomarkers. Curr Opin Anaesthesiol 30:66–75

    CAS  Google Scholar 

  7. Ho J, Tangri N, Komenda P et al (2015) Urinary, plasma, and serum biomarkers’ utility for predicting acute kidney injury associated with cardiac surgery in adults: a meta-analysis. Am J Kidney Dis 66:993–1005

    Article  CAS  Google Scholar 

  8. Huen SC, Parikh CR (2015) Molecular phenotyping of clinical AKI with novel urinary biomarkers. Am J Physiol Renal Physiol 309:F406–F413

    Article  CAS  PubMed  Google Scholar 

  9. KDIGO (2012) Clinical practice guideline for acute kidney injury. Kidney Int 2(Suppl 2):1–149

    Google Scholar 

  10. Fuhrman DY, Kellum JA (2017) Epidemiology and pathophysiology of cardiac surgery-associated acute kidney injury. Curr Opin Anaesthesiol 30:60–65

    CAS  Google Scholar 

  11. Ortega-Loubon C, Fernández-Molina M, Carrascal-Hinojal Y, Fulquet-Carreras E (2016) Cardiac surgery-associated acute kidney injury. Ann Card Anaesth 19:687–698

    Article  PubMed  Google Scholar 

  12. Moore EM, Bellomo R, Nichol AD (2012) The meaning of acute kidney injury and its relevance to intensive care and anaesthesia. Anaesth Intensive Care 40:929–948

    CAS  Google Scholar 

  13. Wang Y, Bellomo R (2017) Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nat Rev Nephrol 13:697–711

    Article  Google Scholar 

  14. Gómez H, Kellum JA (2016) Sepsis-induced acute kidney injury. Curr Opin Crit Care 22:546–553

    Article  PubMed  Google Scholar 

  15. Wei J, Song J, Jiang S et al (2017) Role of intratubular pressure during the ischemic phase in acute kidney injury. Am J Physiol Renal Physiol 312:F1158–F1165

    Article  CAS  Google Scholar 

  16. Parissis H, Mbarushimana S, Ramesh BC et al (2015) The impact of off-pump surgery in end-organ function: practical end-points. J Cardiothorac Surg 10:159

    Article  PubMed  Google Scholar 

  17. Mårtensson J, Martling CR, Bell M (2012) Novel biomarkers of acute kidney injury and failure: clinical applicability. Br J Anaesth 109:843–850

    Article  Google Scholar 

  18. Mosa OF, Skitek M, Kalisnik JM, Jerin A (2016) Evaluation of serum cysteine-rich protein 61 and cystatin C levels for assessment of acute kidney injury after cardiac surgery. Ren Fail 38:699–705

    Article  CAS  Google Scholar 

  19. Svensson AS, Kvitting JP, Kovesdy CP, Cederholm I, Szabó Z (2016) Changes in serum cystatin C, creatinine, and C-reactive protein after cardiopulmonary bypass in patients with normal preoperative kidney function. Nephrology (Carlton) 21:519–525

    Article  CAS  Google Scholar 

  20. Koyner JL, Garg AX, Shlipak MG et al (2013) Urinary cystatin C and acute kidney injury after cardiac surgery. Am J Kidney Dis 61:730–738

    Article  CAS  PubMed  Google Scholar 

  21. Shlipak MG, Coca SG, Wang Z et al (2011) Presurgical serum cystatin C and risk of acute kidney injury after cardiac surgery. Am J Kidney Dis 58:366–373

    Article  CAS  PubMed  Google Scholar 

  22. Spahillari A, Parik CR, Sint K et al (2012) Serum cystatin C – versus creatinine-based definitions of acute kidney injury following cardiac surgery: a prospective cohort study. Am J Kidney Dis 60:922–929

    Article  CAS  PubMed  Google Scholar 

  23. Kashani K, Cheungpasitporn W, Ronco C (2017) Biomarkers of acute kidney injury: the pathway from discovery to clinical adoption. Clin Chem Lab Med 55:1074–1089

    Article  CAS  Google Scholar 

  24. McIlroy DR, Wagener G, Lee HT (2010) Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance. Clin J Am Soc Nephrol 5:211–219

    Article  CAS  PubMed  Google Scholar 

  25. Wagener G, Jan M, Kim M et al (2006) Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology 105:485–491

    Article  CAS  Google Scholar 

  26. Paarmann H, Charitos EI, Beilharz A et al (2013) Duration of cardiopulmonary bypass is an important confounder when using biomarkers for early diagnosis of acute kidney injury in cardiac surgical patients. Appl Cardiopulm Pathophysiol 17:284–297

    Google Scholar 

  27. Koyner JL, Vaidya VS, Bennett MR et al (2010) Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol 5:2154–2165

    Article  CAS  PubMed  Google Scholar 

  28. Emlet DR, Pastor-Soler N, Marciszyn A et al (2017) Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells. Am J Physiol Renal Physiol 312:F284–F296

    Article  CAS  Google Scholar 

  29. Kashani K, Al-Khafaji A, Ardiles T et al (2013) Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 17:R25

    Article  PubMed  Google Scholar 

  30. Jia HM, Huang LF, Zheng Y, Li WX (2017) Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis. Crit Care 21:77

    Article  PubMed  Google Scholar 

  31. Meersch M, Schmidt C, Van Aken H et al (2014) Urinary TIMP-2 and IGFBP7 as early biomarkers of acute kidney injury and renal recovery following cardiac surgery. PLoS One 9:e93460

    Article  PubMed  Google Scholar 

  32. Pilarczyk K, Edayadiyil-Dudasova M, Wendt D et al (2015) Urinary [TIMP-2]*[IGFBP7] for early prediction of acute kidney injury after coronary artery bypass surgery. Ann Intensive Care 5:50

    Article  PubMed  Google Scholar 

  33. Finge T, Bertran S, Roger C et al (2017) Interest of urinary [TIMP-2] × [IGFBP-7] for predicting the occurrence of acute kidney injury after cardiac surgery: a gray zone approach. Anesth Analg 125:762–769

    Article  CAS  PubMed  Google Scholar 

  34. Ralib AM, Pickering JW, Shaw GM et al (2012) Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol 23:322–333

    Article  CAS  PubMed  Google Scholar 

  35. Elmedany SM, Naga SS, Elsharkawy R, Mahrous RS, Elnaggar AI (2017) Novel urinary biomarkers and the early detection of acute kidney injury after open cardiac surgeries. J Crit Care 40:171–177

    Article  PubMed  Google Scholar 

  36. Lassnigg A, Schmidlin D, Mouhieddine M et al (2004) Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol 15:1597–1605

    Article  CAS  PubMed  Google Scholar 

  37. De Loor J, Herck I, Francois K et al (2017) Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study. Ann Intensive Care 7:24

    Article  PubMed  Google Scholar 

  38. Sugimoto K, Toda Y, Iwasaki T et al (2016) Urinary albumin levels predict development of acute kidney injury after pediatric cardiac surgery: a prospective observational study. J Cardiothorac Vasc Anesth 30:64–68

    Article  CAS  Google Scholar 

  39. Tziakas D, Chalikias G, Kareli D et al (2015) Spot urine albumin to creatinine ratio outperforms novel acute kidney injury biomarkers in patients with acute myocardial infarction. Int J Cardiol 197:48–55

    Article  Google Scholar 

  40. Molnar AO, Parikh CR, Sint K et al (2012) Association of postoperative proteinuria with AKI after cardiac surgery among patients at high risk. Clin J Am Soc Nephrol 7:1749–1760

    Article  PubMed  Google Scholar 

  41. Levey AS, Becker C, Inker LA (2015) Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review. JAMA 313:837–846

    Article  CAS  PubMed  Google Scholar 

  42. Momen A, Thomas K, Blaha C et al (2006) Renal vasoconstrictor responses to static exercise during orthostatic stress in humans: effects of the muscle mechano- and the baroreflexes. J Physiol 573:819–825

    Article  CAS  PubMed  Google Scholar 

  43. Bossard G, Bourgoin P, Corbeau JJ, Huntzinger J, Beydon L (2011) Early detection of postoperative acute kidney injury by Doppler renal resistive index in cardiac surgery with cardiopulmonary bypass. Br J Anaesth 107:891–898

    Article  CAS  Google Scholar 

  44. Ninet S, Schnell D, Dewitte A, Zeni F, Meziani F, Darmon M (2015) Doppler-based renal resistive index for prediction of renal dysfunction reversibility: A systematic review and meta-analysis. J Crit Care 30:629–635

    Article  Google Scholar 

  45. Choi DK, Kim WJ, Chin JH et al (2014) Intraoperative renal regional oxygen desaturation can be a predictor for acute kidney injury after Cardiac Surgery. J Cardiothorac Vasc Anesth 28:564–571

    Article  Google Scholar 

  46. Molitoris BA, Reilly E (2016) Quantifying glomerular filtration rates in acute kidney injury: a requirement for translational success. Semin Nephrol 36:31–41

    Article  PubMed  Google Scholar 

  47. Chawla LS, Danielle L et al (2013) Development and standardization of a furosemide stress test to predict the severity of acute kidney injury. Crit Care 17:R207

    Article  PubMed  Google Scholar 

  48. Lassnigg A, Schmid ER, Hiesmayr M et al (2008) Impact of minimal increases in serum creatinine on outcome in patients after cardiothoracic surgery: do we have to revise current definitions of acute renal failure? Crit Care Med 36:1129–1137

    Article  CAS  Google Scholar 

  49. Rubini Gimenez M, Twerenbold R, Reichlin T et al (2014) Direct comparison of high-sensitivity-cardiac troponin I vs. T for the early diagnosis of acute myocardial infarction. Eur Heart J 35:2303–2323

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. Heringlake .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Heringlake, M., Schmidt, C., Berggreen, A.E. (2018). Early Detection of Acute Kidney Injury after Cardiac Surgery: A Problem Solved?. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2018. Annual Update in Intensive Care and Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-73670-9_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-73670-9_26

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-73669-3

  • Online ISBN: 978-3-319-73670-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics