Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)
Emerging Technology Platforms for Optical Molecular Imaging and Sensing at the Alveolar Level in the Critically ill
Advances in the understanding of various disease processes have outstripped the clinical care of critically ill patients. Diagnosis, quantification, monitoring and management are often determined through pattern recognition of clinical features rather than reliance on ‘true’ pathological sampling. There is a great deal of uncertainty surrounding the true presence of disease in many organ systems and especially in pulmonary critical care in diseases such as pneumonia and acute respiratory distress syndrome (ARDS). Formal pulmonary biopsy may provide certainty regarding the diagnosis but is not often performed due to perceived peril, patchy nature of a single sample and the absence of serial biopsy to facilitate monitoring. New developments in biophotonics, fiberoptics, chemistry and image analysis may provide the opportunity to perform real time in vivooptical molecular biopsy at the bedside. Healthcare biophotonics is a relatively novel, interdisciplinary science that...
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