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Orthopedic Biomaterials pp 109–139Cite as

Biomimetic Orthopedic Materials

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Abstract

Biomimetics refers to the design and engineering of artificial materials, structures, and systems that emulate those naturally occurring in biological entities. In recent years, interdisciplinary approaches based on biomimicry, materials sciences, and tissue engineering have enabled the development of biomimetic materials with defined chemical composition, physical structure, and biological function for a wide range of biomedical applications. These types of materials mimic the biochemical properties of native tissues, while also possessing the physical properties of core materials. Hence, they can be used to deliver different types of physiological stimuli that can modulate cell behavior. Significant efforts have been made to engineer biomimetic materials that can recapitulate specific features of the native ECM to act as bioactive templates to promote the repair and functional reconstruction of various types of tissues. In this chapter, we will provide an overview of current trends in the design of biomimetic orthopedic materials, which feature structural and functional properties inspired from biological entities.

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Acknowledgements

N.A. acknowledges the support from the National Institutes of Health (NIH, R01EB023052-01A1, R01HL140618-01), the American Heart Association (AHA, 16SDG31280010), The Center for Dental, Oral & Craniofacial Tissue & Organ Regeneration (C-DOCTOR) Interdisciplinary Project Team award, FY17 TIER 1 Interdisciplinary Research Seed Grants from Northeastern University, and the startup fund provided by the Department of Chemical Engineering, College of Engineering at Northeastern University. R.P.L. acknowledges institutional funding received from the Escuela de Ingeniería y Ciencias at Tecnológico de Monterrey, México (L03022214).

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Author notes

  1. Portillo-Lara and Shirzaei Sani contributed equally to this work.

Authors and Affiliations

  1. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    R. Portillo-Lara, E. Shirzaei Sani & N. Annabi

  2. Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Zapopan, JAL, Mexico

    R. Portillo-Lara

  3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

    N. Annabi

  4. Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    N. Annabi

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  1. R. Portillo-Lara
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  2. E. Shirzaei Sani
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  3. N. Annabi
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Correspondence to N. Annabi .

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Editors and Affiliations

  1. Department of Orthopedics, School of Medicine, West Virginia University, Morgantown, West Virginia, USA

    Bingyun Li

  2. Chemical Engineering, Northeastern University, Boston, Massachusetts, USA

    Thomas Webster

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Portillo-Lara, R., Shirzaei Sani, E., Annabi, N. (2017). Biomimetic Orthopedic Materials. In: Li, B., Webster, T. (eds) Orthopedic Biomaterials. Springer, Cham. https://doi.org/10.1007/978-3-319-73664-8_5

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