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Surface Modification and Coatings for Controlling the Degradation and Bioactivity of Magnesium Alloys for Medical Applications

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Orthopedic Biomaterials

Abstract

Magnesium (Mg) alloys have great potential as materials for biodegradable implants and devices because of their excellent mechanical and biological properties; such as the similarity of their mechanical properties to cortical bone and their osteoconductivity. However, Mg alloys degrade rapidly in vivo, which reduces the local pH and can harm cells. Coatings and surface treatments can control the degradation rate of Mg alloys by limiting the diffusion of water and ions to the Mg surface. Coatings can also increase the osteoconductivity of the surface of Mg implants. Polymers and ceramics are frequently used as coating materials, and the processes of their deposition can further tailor the properties of coatings for their intended roles. The controlled degradation and osteoconductivity of Mg implants using coatings will lead to their replacement with natural tissue after they have fulfilled their function; which will avoid foreign body complications and prevent the need for implant removal surgeries.

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Acknowledgement

The authors thank U.S. National Science Foundation (Award 1512764, 1125801) and National Institutes of Health (Award 1R03AR069373-01) for financial support. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Science Foundation and National Institutes of Health.

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Authors and Affiliations

  1. Dental and Craniofacial Trauma Research, US Army Institute of Surgical Research, Houston, TX, USA

    Ian Johnson

  2. Department of Bioengineering, University of California, Riverside, Riverside, CA, USA

    Ian Johnson & Huinan Liu

  3. Materials Science and Engineering, University of California, Riverside, CA, USA

    Jiajia Lin & Huinan Liu

Authors
  1. Ian Johnson
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  2. Jiajia Lin
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  3. Huinan Liu
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Correspondence to Huinan Liu .

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Editors and Affiliations

  1. Department of Orthopedics, School of Medicine, West Virginia University, Morgantown, West Virginia, USA

    Bingyun Li

  2. Chemical Engineering, Northeastern University, Boston, Massachusetts, USA

    Thomas Webster

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Johnson, I., Lin, J., Liu, H. (2017). Surface Modification and Coatings for Controlling the Degradation and Bioactivity of Magnesium Alloys for Medical Applications. In: Li, B., Webster, T. (eds) Orthopedic Biomaterials. Springer, Cham. https://doi.org/10.1007/978-3-319-73664-8_13

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