Electrodiagnosis of Neuromuscular Junction Disorders

  • Christopher David Geiger
  • Bashar Katirji
Part of the Current Clinical Neurology book series (CCNEU)


The electrodiagnostic (EDX) examination in patients with suspected neuromuscular junction (NMJ) disorders requires a sound working knowledge of the physiology and pathophysiology of neuromuscular transmission. The EDX studies that are useful in the evaluation of such patients include (1) motor nerve conduction studies (NCSs), (2) conventional needle electromyography (EMG), (3) repetitive nerve stimulation (RNS), and (4) single-fiber EMG. This chapter reviews the basics of neuromuscular transmission, as it relates to the EDX studies, and discusses in detail the EDX studies and findings in various NMJ disorders.


Neuromuscular transmission Electrodiagnostic examination Neuromuscular junction disorders Motor nerve conduction studies Conventional needle electromyography Repetitive nerve stimulation Single-fiber electromyography 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyUniversity Hospitals Cleveland Medical Center/Case Western Reserve UniversityClevelandUSA
  2. 2.Neurological Institute, Bowlell Health CenterClevelandUSA

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