Epidemiology and Genetics of Myasthenia Gravis

Chapter
Part of the Current Clinical Neurology book series (CCNEU)

Abstract

Myasthenia gravis (MG) appears to have a similar incidence among populations worldwide. While MG was previously considered to be an autoimmune disease of young woman, in the last three decades, it has increasingly been recognized to more commonly manifest in older people and predominantly men. Apart from these sex differences, there are racial differences. MuSK antibody-positive disease appears to be more frequent among those with African genetic ancestry. In addition, certain racial groups may be more at risk of developing a treatment-resistant ophthalmoplegic subphenotype of MG. Although many MG case-control association studies have been performed focusing on specific gene candidates, the advent of next-generation sequencing technology has allowed genome-wide association studies (GWAS) to assess gene and marker variants in larger population sets. Interestingly, these GWAS show the strongest associations with the HLA region. Overall, the GWAS studies are showing (a) that gene variants associated with MG are not rare in the population, (b) that there are different gene associations by MG subtype, and (c) that an individual’s genetic background is predicted to account for around 35% of MG heritability suggesting a substantial environmental contribution to MG risk.

Keywords

Epidemiology Race Caucasian African Asian Subgroups Subphenotypes Genetic GWAS Epigenetics HLA 

Notes

Acknowledgments

MN and JMH have received financial support from the South African (SA) Medical Research Center (MRC) and the SA National Research Fund, as well as the AFM Telethon.

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neurology Research Group, Department of MedicineGroote Schuur Hospital and University of Cape TownCape TownSouth Africa
  2. 2.Division of Neurology, Department of MedicineGroote Schuur Hospital, Groote Schuur Hospital and University of Cape TownCape TownSouth Africa

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