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Sepsis in Low- and Middle-Income Countries

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Handbook of Sepsis

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Abstract

Sepsis is one of the oldest and most complex syndromes in medicine that still poses a significant challenge to healthcare professionals worldwide. Despite current epidemiological data suggesting a huge global burden of sepsis, knowledge regarding the incidence, prevalence, and mortality rates of sepsis is scarce, especially in low- and middle-income countries, which comprise 85% of the world’s population and usually have higher mortality rates than high-income countries. Possible reasons for the increased mortality due to sepsis in low- and middle-income countries are low sepsis awareness among the lay public and healthcare workers, care provision constraints, inadequate access to intensive care, a high incidence of nosocomial infections, and ineffective preventive measures. To understand the impact of sepsis on healthcare in resource-limited areas, adequately designed studies from low- and middle-income countries assessing the epidemiology, long-term outcomes, and quality improvement initiatives for sepsis are urgently needed. The purpose of this review is to discuss the epidemiology of sepsis in low- and middle-income countries and the differences between these patterns and those in high-income countries that may be responsible for the increased case fatalities, as well as quality improvement initiatives for sepsis care in resource-constrained settings.

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Authors and Affiliations

  1. Discipline of Emergency Medicine, University of São Paulo, São Paulo, Brazil

    Luciano Cesar Pontes Azevedo M.D., Ph.D.

  2. Hospital Sirio-Libanes, São Paulo, Brazil

    Luciano Cesar Pontes Azevedo M.D., Ph.D.

  3. Latin-American Sepsis Institute, R. Pedro de Toledo, 980 cj 94 São Paulo, São Paulo, Brazil

    Luciano Cesar Pontes Azevedo M.D., Ph.D. & Flavia Ribeiro Machado M.D., Ph.D.

  4. Discipline of Anesthesiology, Pain and Intensive Care, Federal University of São Paulo, São Paulo, Brazil

    Flavia Ribeiro Machado M.D., Ph.D.

Authors
  1. Luciano Cesar Pontes Azevedo M.D., Ph.D.
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  2. Flavia Ribeiro Machado M.D., Ph.D.
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Correspondence to Flavia Ribeiro Machado M.D., Ph.D. .

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Editors and Affiliations

  1. University of Amsterdam, Amsterdam, The Netherlands

    W. Joost Wiersinga

  2. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Christopher W. Seymour

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Azevedo, L.C.P., Machado, F.R. (2018). Sepsis in Low- and Middle-Income Countries. In: Wiersinga, W., Seymour, C. (eds) Handbook of Sepsis. Springer, Cham. https://doi.org/10.1007/978-3-319-73506-1_15

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