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Mitochondrial Biology and Experimental Therapeutics pp 637–645Cite as

SkQ1: The Road from Laboratory Bench to the Market

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Abstract

SkQ1 and other mitochondria-targeted plastoquinone derivatives are promising drug candidates for the treatment of pathologies associated with mitochondrial dysfunction. Experiments in animals revealed that SkQ alleviates damage induced by ischemia-reperfusion injury, prevents autoimmune arthritis, suppresses the development of Alzheimer’s disease signs, inhibits the development of ophthalmological disorders, including dry eye syndrome (DES), and has anti-inflammatory activity. The first SkQ-based drug (Visomitin eye drops) is already developed and registered in Russia; clinical studies of orally administered drug is in progress. In this review, we summarize recent experimental data on SkQ effects in animals, results of clinical trials and future perspectives of mitochondria-targeted antioxidants as therapeutic compounds.

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Acknowledgements

This work was supported by the Russian Science Foundation (Project No. 14-50-00029).

Conflict of Interest

 M.V.S. is the general director of Mitotech LLC, a biotech company which owns rights for compounds of SkQ type.

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Authors and Affiliations

  1. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia

    Boris A. Feniouk

  2. A.N. Belozersky Institute of Physico–Chemical Biology, Lomonosov Moscow State University, Moscow, Russia

    Boris A. Feniouk & Maxim V. Skulachev

  3. Institute of Mitoengineering, Moscow State University, Moscow, Russia

    Maxim V. Skulachev

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  1. Boris A. Feniouk
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  2. Maxim V. Skulachev
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Correspondence to Maxim V. Skulachev .

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Editors and Affiliations

  1. CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

    Paulo J. Oliveira

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Feniouk, B.A., Skulachev, M.V. (2018). SkQ1: The Road from Laboratory Bench to the Market. In: Oliveira, P. (eds) Mitochondrial Biology and Experimental Therapeutics. Springer, Cham. https://doi.org/10.1007/978-3-319-73344-9_28

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