Skip to main content
SpringerLink
Log in

Impact of Pharmaceutically Active Compounds in Marine Environment on Aquaculture

  • Chapter
  • First Online:
Sustainable Aquaculture

Abstract

Occurrence of pharmaceutically active compounds (PhACs) in marine ecosystems has been confirmed in recent studies. These PhACs include human pharmaceuticals, veterinary medicines and those used in aquaculture . Levels of PhACs in the marine environment are suspected to rise in future due to the increase in anthropogenic activities. This chapter critically discusses the occurrence, sources and fate of PhACs in marine environment. A particular focus has been given to the adverse impacts of PhACs on marine biota and the potential exposure to human. Data related to the distribution of PhACs in seawater , sea sediments and marine biota is presented to elucidate their bioconcentration and bioaccumulation potential. Impacts of PhACs at cellular, molecular and species level are summarised here to understand their mode of action. Lastly, potential biomarkers for effective biomonitoring of marine environment are highlighted to anticipate the risks related to marine ecosystem and human health.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aguirre-Martinez GV, del Valls TA, Martín-Díaz ML (2013a) Early responses measured in the brachyuran crab Carcinus maenas exposed to carbamazepine and novobiocin: application of a 2-tier approach. Ecotoxicol Environ Saf 97:47–58

    Google Scholar 

  • Aguirre-Martinez GV, Buratti S, Fabbri E, del Valls TA, Martin-Diaz ML (2013b) Stability of lysosomal membrane in Carcinus maenas acts as a biomarker of exposure to pharmaceuticals. Environ Monit Assess 185:3783–3793

    Google Scholar 

  • Aguirre-Martínez GV, Buratti S, Fabbri E, Delvalls AT, Martín-Díaz ML (2013c) Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin. J Environ Sci 25:1408–1418

    Google Scholar 

  • Ahmad A, Khan MU, Patel I, Maharaj S, Pandey S, Dhingra S (2015). Knowledge, attitude and practice of B. Sc. Pharmacy students about antibiotics in Trinidad and Tobago. J Res Pharm Pract 4:37

    Google Scholar 

  • Akinbowale OL, Peng H, Barton M (2006) Antimicrobial resistance in bacteria isolated from aquaculture sources in Australia. J Appl Microbiol 100:1103–1113

    Article  CAS  Google Scholar 

  • Almeida Â, Calisto V, Esteves VI, Schneider RJ, Soares AM, Figueira E, Freitas R (2014) Presence of the pharmaceutical drug carbamazepine in coastal systems: effects on bivalves. Aquat Toxicol 156:74–87

    Article  CAS  Google Scholar 

  • Alvarez-Muñoz D, Huerta B, Fernandez-Tejedor M, Rodríguez-Mozaz S, Barceló D (2015) Multi-residue method for the analysis of pharmaceuticals and some of their metabolites in bivalves. Talanta 136:174–182

    Article  CAS  Google Scholar 

  • Antunes S, Freitas R, Figueira E, Gonçalves F, Nunes B (2013) Biochemical effects of acetaminophen in aquatic species: edible clams Venerupis decussata and Venerupis philippinarum. Environ Sci Pollut Res 20:6658–6666

    Article  CAS  Google Scholar 

  • Arpin-Pont L, Bueno MJM, Gomez E, Fenet H (2016) Occurrence of PPCPs in the marine environment: a review. Environ Sci Pollut Res 23:4978–4991

    Article  Google Scholar 

  • Asif MB, Hai FI, Singh L, Price WE, Nghiem LD (2017a) Degradation of pharmaceuticals and personal care products by white-rot fungi—a critical review. Curr Pollut Rep 3:88–103

    Article  CAS  Google Scholar 

  • Asif MB, Hai FI, Hou J, Price WE, Nghiem LD (2017) Impact of wastewater derived dissolved interfering compounds on growth, enzymatic activity and trace organic contaminant removal of white rot fungie—a critical review. J Environ Manag 201:89–109

    Google Scholar 

  • Austin B, Al-Zahrani A (1988) The effect of antimicrobial compounds on the gastrointestinal microflora of rainbow trout, Salmo gairdneri Richardson. J Fish Biol 33:1–14

    Article  CAS  Google Scholar 

  • Avendaño-Herrera R, Núñez S, Barja JL, Toranzo AE (2008) Evolution of drug resistance and minimum inhibitory concentration to enrofloxacin in Tenacibaculum maritimum strains isolated in fish farms. Aquacult Int 16:1–11

    Article  CAS  Google Scholar 

  • Bakkali F, Averbeck S, Averbeck D, Idaomar M (2008) Biological effects of essential oils—a review. Food Chem Toxicol 46:446–475

    Article  CAS  Google Scholar 

  • Balmer ME, Buser H-R, Müller MD, Poiger T (2005) Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss lakes. Environ Sci Technol 39:953–962

    Article  CAS  Google Scholar 

  • Banni M, Sforzini S, Franzellitti S, Oliveri C, Viarengo A, Fabbri E (2015) Molecular and cellular effects induced in Mytilus galloprovincialis treated with oxytetracycline at different temperatures. PLoS ONE 10:e0128468

    Article  CAS  Google Scholar 

  • Barbier EB, Hacker SD, Kennedy C, Koch EW, Stier AC, Silliman BR (2011) The value of estuarine and coastal ecosystem services. Ecol Monogr 81:169–193

    Article  Google Scholar 

  • Bates JM, Mittge E, Kuhlman J, Baden KN, Cheesman SE, Guillemin K (2006) Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. Dev Biol 297:374–386

    Article  CAS  Google Scholar 

  • Bayen S, Zhang H, Desai MM, Ooi SK, Kelly BC (2013) Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore’s marine environment: influence of hydrodynamics and physical–chemical properties. Environ Pollut 182:1–8

    Article  CAS  Google Scholar 

  • Benotti MJ, Brownawell BJ (2007) Distributions of pharmaceuticals in an urban estuary during both dry-and wet-weather conditions. Environ Sci Technol 41:5795–5802

    Article  CAS  Google Scholar 

  • Bertin A, Inostroza PA, Quiñones RA (2011) Estrogen pollution in a highly productive ecosystem off central-south Chile. Mar Pollut Bull 62:1530–1537

    Article  CAS  Google Scholar 

  • Boden AR, Reiner EJ (2004) Development of an isotope-dilution gas chromatographic-mass spectrometric method for the analysis of polycyclic aromatic compounds in environmental matrices. Polycyclic Aromat Compd 24:309–323

    Article  CAS  Google Scholar 

  • Brausch JM, Rand GM (2011) A review of personal care products in the aquatic environment: environmental concentrations and toxicity. Chemosphere 82:1518–1532

    Article  CAS  Google Scholar 

  • Brooks BW, Foran CM, Richards SM, Weston J, Turner PK, Stanley JK, Solomon KR, Slattery M, la Point TW (2003) Aquatic ecotoxicology of fluoxetine. Toxicol Lett 142:169–183

    Article  CAS  Google Scholar 

  • Broughton EI, Walker DG (2009) Prevalence of antibiotic-resistant Salmonella in fish in Guangdong, China. Foodborne Pathog Dis 6:519–521

    Article  CAS  Google Scholar 

  • Bueno MM, Boillot C, Fenet H, Chiron S, Casellas C, Gómez E (2013) Fast and easy extraction combined with high resolution-mass spectrometry for residue analysis of two anticonvulsants and their transformation products in marine mussels. J Chromatogr A 1305:27–34

    Article  CAS  Google Scholar 

  • Burridge L, Weis JS, Cabello F, Pizarro J, Bostick K (2010) Chemical use in salmon aquaculture: a review of current practices and possible environmental effects. Aquaculture 306:7–23

    Article  CAS  Google Scholar 

  • Caban M, Migowska N, Stepnowski P, Kwiatkowski M, Kumirska J (2012) Matrix effects and recovery calculations in analyses of pharmaceuticals based on the determination of β-blockers and β-agonists in environmental samples. J Chromatogr A 1258:117–127

    Article  CAS  Google Scholar 

  • Cabello FC (2006) Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment. Environ Microbiol 8:1137–1144

    Article  CAS  Google Scholar 

  • Cabello FC, Godfrey HP, Tomova A, Ivanova L, Dölz H, Millanao A, Buschmann AH (2013) Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. Environ Microbiol 15:1917–1942

    Article  Google Scholar 

  • Chen H, Liu S, Xu X-R, Liu S-S, Zhou G-J, Sun K-F, Zhao J-L, Ying G-G (2015) Antibiotics in typical marine aquaculture farms surrounding Hailing Island, South China: occurrence, bioaccumulation and human dietary exposure. Mar Pollut Bull 90:181–187

    Article  CAS  Google Scholar 

  • Christen V, Hickmann S, Rechenberg B, Fent K (2010) Highly active human pharmaceuticals in aquatic systems: a concept for their identification based on their mode of action. Aquat Toxicol 96:167–181

    Article  CAS  Google Scholar 

  • Chung I-M, Ahmad A, Kim S-J, Naik PM, Nagella P (2012) Composition of the essential oil constituents from leaves and stems of Korean Coriandrum sativum and their immunotoxicity activity on the Aedes aegypti L. Immunopharmacol Immunotoxicol 34:152–156

    Article  CAS  Google Scholar 

  • Comeau F, Surette C, Brun G, Losier R (2008) The occurrence of acidic drugs and caffeine in sewage effluents and receiving waters from three coastal watersheds in Atlantic Canada. Sci Total Environ 396:132–146

    Article  CAS  Google Scholar 

  • Commission TE (2010) Commission regulation on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. In: Union TE (ed) 37/2010 The European Union

    Google Scholar 

  • Consortium S (2006) Sea lice resistance to chemotherapeutants: a handbook in resistance management. SEARCH, Sacramento, CA, USA

    Google Scholar 

  • Corcoran E (2010) Sick water?: the central role of wastewater management in sustainable development: a rapid response assessment, London, UNEP/Earthprint. (ISBN: 9788277010755)

    Google Scholar 

  • Cortez FS, Pereira CDS, Santos AR, Cesar A, Choueri RB, de Assis Martini G, Bohrer-Morel MB (2012) Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758). Environ Pollut 168:145–150

    Google Scholar 

  • Costanza R, D’Arge R, de Groot R, Farber S, Grasso M, Hannon B, Limburg K, Naeem S, O’Neill RV, Paruelo J (1998) The value of ecosystem services: putting the issues in perspective. Ecol Econ 25:67–72

    Article  Google Scholar 

  • Crain CM, Halpern BS, Beck MW, Kappel CV (2009) Understanding and managing human threats to the coastal marine environment. Ann N Y Acad Sci 1162:39–62

    Article  Google Scholar 

  • Das A, Saha D, Pal J (2009) Antimicrobial resistance and in vitro gene transfer in bacteria isolated from the ulcers of EUS-affected fish in India. Lett Appl Microbiol 49:497–502

    Article  CAS  Google Scholar 

  • Daughton CG, Ruhoy IS (2009) Environmental footprint of pharmaceuticals: the significance of factors beyond direct excretion to sewers. Environ Toxicol Chem 28:2495–2521

    Article  CAS  Google Scholar 

  • Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107:907

    Article  CAS  Google Scholar 

  • Defoirdt T, Sorgeloos P, Bossier P (2011) Alternatives to antibiotics for the control of bacterial disease in aquaculture. Curr Opin Microbiol 14:251–258

    Article  Google Scholar 

  • Díaz-Cruz MS, de Alda MJL, Barcelo D (2003) Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge. TrAC Trends in Anal Chem 22:340–351

    Google Scholar 

  • Dierckens K, Rekecki A, Laureau S, Sorgeloos P, Boon N, van den Broeck W, Bossier P (2009) Development of a bacterial challenge test for gnotobiotic sea bass (Dicentrarchus labrax) larvae. Environ Microbiol 11:526–533

    Article  CAS  Google Scholar 

  • Dimitroglou A, Merrifield DL, Carnevali O, Picchietti S, Avella M, Daniels C, Güroy D, Davies SJ (2011) Microbial manipulations to improve fish health and production—a Mediterranean perspective. Fish Shellfish Immunol 30:1–16

    Article  CAS  Google Scholar 

  • Dodder NG, Maruya KA, Ferguson PL, Grace R, Klosterhaus S, la Guardia MJ, Lauenstein GG, Ramirez J (2014) Occurrence of contaminants of emerging concern in mussels (Mytilus spp.) along the California coast and the influence of land use, storm water discharge, and treated wastewater effluent. Mar Pollut Bull 81:340–346

    Article  CAS  Google Scholar 

  • Du L, Liu W (2012) Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. Rev Agron Sustain Dev 32:309–327

    Article  CAS  Google Scholar 

  • Dung TT, Haesebrouck F, Tuan NA, Sorgeloos P, Baele M, Decostere A (2008) Antimicrobial susceptibility pattern of Edwardsiella ictaluri isolates from natural outbreaks of bacillary necrosis of Pangasianodon hypophthalmus in Vietnam. Microbial Drug Resist 14:311–316

    Article  CAS  Google Scholar 

  • Emke E, Evans S, Kasprzyk-Hordern B, de Voogt P (2014) Enantiomer profiling of high loads of amphetamine and MDMA in communal sewage: a Dutch perspective. Sci Total Environ 487:666–672

    Article  CAS  Google Scholar 

  • Emnet P, Gaw S, Northcott G, Storey B, Graham L (2015) Personal care products and steroid hormones in the Antarctic coastal environment associated with two Antarctic research stations, McMurdo Station and Scott Base. Environ Res 136:331–342

    Article  CAS  Google Scholar 

  • Ennajar M, Afloulous S, Romdhane M, Ibrahim H, Cazaux S, Abderraba M, Raies A, Bouajila J (2011) Influence of the process, season, and origin on volatile composition and antioxidant activity of Juniperus phoenicea L. leaves essential oils. J Food Sci 76:C224–C230

    Article  CAS  Google Scholar 

  • Evgenidou EN, Konstantinou IK, Lambropoulou DA (2015) Occurrence and removal of transformation products of PPCPs and illicit drugs in wastewaters: a review. Sci Total Environ 505:905–926

    Article  CAS  Google Scholar 

  • Fabbri E, Capuzzo A (2010) Cyclic AMP signaling in bivalve molluscs: an overview. J Exp Zool Part A: Ecol Genet Physiol 313:179–200

    Google Scholar 

  • Fabbri E, Franzellitti S (2015) Human pharmaceuticals in the marine environment: focus on exposure and biological effects in animal species. Environ Toxicol Chem

    Google Scholar 

  • Fabbri E, Franzellitti S (2016) Human pharmaceuticals in the marine environment: focus on exposure and biological effects in animal species. Environ Toxicol Chem 35:799–812

    Article  CAS  Google Scholar 

  • FAO (2014) The state of world fisheries and aquaculture opportunities and challenges. Food and Agriculture Organization of the United Nations, Rome. ISBN: 9789251082768 (Assessed from https://www.fao.org/3/a-i3720e.pdf)

  • Fedorova G, Nebesky V, Randak T, Grabic R (2014) Simultaneous determination of 32 antibiotics in aquaculture products using LC-MS/MS. Chem Pap 68:29–36

    Article  CAS  Google Scholar 

  • Fenet H, Arpin-Pont L, Vanhoutte-Brunier A, Munaron D, Fiandrino A, Bueno M-JM, Boillot C, Casellas C, Mathieu O, Gomez E (2014) Reducing PEC uncertainty in coastal zones: a case study on carbamazepine, oxcarbazepine and their metabolites. Environ Int 68:177–184

    Article  CAS  Google Scholar 

  • Fernández-Alarcón C, Miranda C, Singer R, Lopez Y, Rojas R, Bello H, Dominguez M, González-Rocha G (2010) Detection of the floR gene in a diversity of florfenicol resistant gram-negative bacilli from freshwater salmon farms in Chile. Zoonoses Pub Health 57:181–188

    Article  CAS  Google Scholar 

  • Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Tysklind M, Larsson DGJ (2010) Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents. Environ Sci Technol 44:2661–2666

    Article  CAS  Google Scholar 

  • Ford AT, Fong PP (2016) The effects of antidepressants appear to be rapid and at environmentally relevant concentrations. Environ Toxicol Chem 35:794–798

    Article  CAS  Google Scholar 

  • Franzellitti S, Buratti S, Capolupo M, Du B, Haddad SP, Chambliss CK, Brooks BW, Fabbri E (2014) An exploratory investigation of various modes of action and potential adverse outcomes of fluoxetine in marine mussels. Aquat Toxicol 151:14–26

    Article  CAS  Google Scholar 

  • Franzellitti S, Buratti S, Du B, Haddad SP, Chambliss CK, Brooks BW, Fabbri E (2015) A multibiomarker approach to explore interactive effects of propranolol and fluoxetine in marine mussels. Environ Pollut 205:60–69

    Article  CAS  Google Scholar 

  • Franzellitti S, Buratti S, Valbonesi P, Capuzzo A, Fabbri E (2011) The beta-blocker propranolol affects cAMP-dependent signaling and induces the stress response in Mediterranean mussels, Mytilus galloprovincialis. Aquat Toxicol 101:299–308

    Article  CAS  Google Scholar 

  • Franzellitti S, Buratti S, Valbonesi P, Fabbri E (2013) The mode of action (MOA) approach reveals interactive effects of environmental pharmaceuticals on Mytilus galloprovincialis. Aquat Toxicol 140–141:249–256

    Article  CAS  Google Scholar 

  • Fu W, Franco A, Trapp S (2009) Methods for estimating the bioconcentration factor of ionizable organic chemicals. Environ Toxicol Chem 28:1372–1379

    Article  CAS  Google Scholar 

  • Garcia SN, Foster M, Constantine LA, Huggett DB (2012) Field and laboratory fish tissue accumulation of the anti-convulsant drug carbamazepine. Ecotoxicol Environ Saf 84:207–211

    Article  CAS  Google Scholar 

  • Gaw S, Thomas KV, Hutchinson TH (2014) Sources, impacts and trends of pharmaceuticals in the marine and coastal environment. Phil Trans R Soc B 369:20130572

    Article  Google Scholar 

  • Gilroy ÈA, Balakrishnan VK, Solomon KR, Sverko E, Sibley PK (2012) Behaviour of pharmaceuticals in spiked lake sediments–effects and interactions with benthic invertebrates. Chemosphere 86:578–584

    Article  CAS  Google Scholar 

  • Glassmeyer ST, Koplin DW, Furlong ET, Focazio M (2008) Environmental presence and persistence of pharmaceuticals: An overview. In: Aga DS (ed) Fate of pharmaceuticals in the environment and in water treatment systems. CRC Press, Boca Raton. ISBN: 9781420052329

    Google Scholar 

  • Gomez E, Bachelot M, Boillot C, Munaron D, Chiron S, Casellas C, Fenet H (2012) Bioconcentration of two pharmaceuticals (benzodiazepines) and two personal care products (UV filters) in marine mussels (Mytilus galloprovincialis) under controlled laboratory conditions. Environ Sci Pollut Res 19:2561–2569

    Article  CAS  Google Scholar 

  • Gómez MJ, Petrović M, Fernández-Alba AR, Barceló D (2006) Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography–tandem mass spectrometry analysis in hospital effluent wastewaters. J Chromatogr A 1114:224–233

    Article  CAS  Google Scholar 

  • Gonzalez-Rey M, Bebianno MJ (2012) Does non-steroidal anti-inflammatory (NSAID) ibuprofen induce antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis? Environ Toxicol Pharmacol 33:361–371

    Article  CAS  Google Scholar 

  • Gonzalez-Rey M, Bebianno MJ (2014) Effects of non-steroidal anti-inflammatory drug (NSAID) diclofenac exposure in mussel Mytilus galloprovincialis. Aquat Toxicol 148:221–230

    Article  CAS  Google Scholar 

  • Grigorakis K, Rigos G (2011) Aquaculture effects on environmental and public welfare—the case of Mediterranean mariculture. Chemosphere 85:899–919

    Article  CAS  Google Scholar 

  • Guardabassi L, Courvalin P (2006) Modes of antimicrobial action and mechanisms of bacterial resistance. In: Aarestrup FM (ed) Antimicrobial resistance in bacteria of animal origin. American Society of Microbiology, Washington, DC. https://doi.org/10.1128/9781555817534.ch1

  • Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DJ (2008) Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol 42:5807–5813

    Article  CAS  Google Scholar 

  • Hai FI, Alturki A, Nguyen LN, Price WE, Nghiem LD (2016) Removal of trace organic contaminants by integrated membrane processes for water reuse applications. In: Ngo HH, Guo W, Surampalli RY, Zhang TC (eds) Green technologies for sustainable water management. American Society of Civil Engineers, New York. ISBN: 9780784414422

    Google Scholar 

  • Hai FI, Nghiem LD, Khan SJ, Price WE, Yamamoto K (2014a) Wastewater reuse: removal of emerging trace organic contaminants (TrOC). In: Hai FI, Yamamoto K, Lee CH (eds) Membrane Biological Reactors: Theory, Modeling, Design, Management. IWA Publishing, London. ISBN: 9781780400655

    Google Scholar 

  • Hai FI, Nguyen LN, Nghiem LD, Liao B-Q, Koyuncu I, Price WE (2014b) Trace organic contaminants removal by combined processes for wastewater reuse. In: Fatta-Kassinos D, Dionysiou DD, Kümmerer K (eds) Advanced treatment technologies for urban wastewater reuse. Springer, Gewerbestrasse. ISBN: 9783319238869

    Google Scholar 

  • Hai FI, Tadkaew N, McDonald JA, Khan SJ, Nghiem LD (2011) Is halogen content the most important factor in the removal of halogenated trace organics by MBR treatment? Biores Technol 102:6299–6303

    Article  CAS  Google Scholar 

  • Hai FI, Yamamoto K, Lee CH (2014c) Membrane biological reactors: theory, modeling, design, management and applications to wastewater reuse. IWA Publishing, London. ISBN: 9781780400655

    Google Scholar 

  • He X, Wang Z, Nie X, Yang Y, Pan D, Leung AO, Cheng Z, Yang Y, Li K, Chen K (2012) Residues of fluoroquinolones in marine aquaculture environment of the Pearl River Delta, South China. Environ Geochem Health 34:323–335

    Article  CAS  Google Scholar 

  • Heuer OE, Kruse H, Grave K, Collignon P, Karunasagar I, Angulo FJ (2009) Human health consequences of use of antimicrobial agents in aquaculture. Clin Infect Dis 49:1248–1253

    Article  Google Scholar 

  • Holmström K, Gräslund S, Wahlström A, Poungshompoo S, Bengtsson B-E, Kautsky N (2003) Antibiotic use in shrimp farming and implications for environmental impacts and human health. Int J Food Sci Technol 38:255–266

    Article  Google Scholar 

  • Howard PH, Muir DC (2011) Identifying new persistent and bioaccumulative organics among chemicals in commerce II: pharmaceuticals. Environ Sci Technol 45:6938–6946

    Article  CAS  Google Scholar 

  • Hughes SR, Kay P, Brown LE (2012) Global synthesis and critical evaluation of pharmaceutical data sets collected from river systems. Environ Sci Technol 47:661–677

    Article  CAS  Google Scholar 

  • Ingram T, Richter U, Mehling T, Smirnova I (2011) Modelling of pH dependent n-octanol/water partition coefficients of ionizable pharmaceuticals. Fluid Phase Equilib 305:197–203

    Article  CAS  Google Scholar 

  • Irianto A, Austin B (2002) Probiotics in aquaculture. J Fish Dis 25:633–642

    Article  Google Scholar 

  • Ishida Y, Ahmed AM, Mahfouz NB, Kimura T, El-Khodery SA, Moawad AA, Shimamoto T (2010) Molecular analysis of antimicrobial resistance in gram-negative bacteria isolated from fish farms in Egypt. J Vet Med Sci 72:727–734

    Article  CAS  Google Scholar 

  • Jia A, Hu J, Wu X, Peng H, Wu S, Dong Z (2011) Occurrence and source apportionment of sulfonamides and their metabolites in Liaodong Bay and the adjacent Liao River Basin, North China. Environ Toxicol Chem 30:1252–1260

    Article  CAS  Google Scholar 

  • Kemper N (2008) Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Ind 8:1–13

    Article  CAS  Google Scholar 

  • Kim S-C, Carlson K (2006) Occurrence of ionophore antibiotics in water and sediments of a mixed-landscape watershed. Water Res 40:2549–2560

    Article  CAS  Google Scholar 

  • Klosterhaus SL, Grace R, Hamilton MC, Yee D (2013) Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary. Environ Int 54:92–99

    Article  CAS  Google Scholar 

  • Knight J, Taylor GW, Wright P, Clare AS, Rowley AF (1999) Eicosanoid biosynthesis in an advanced deuterostomate invertebrate, the sea squirt (Ciona intestinalis). Biochim et Biophys Acta (BBA)-Mol Cell Biol Lipids 1436:467–478

    Google Scholar 

  • Kookana RS, Williams M, Boxall AB, Larsson DJ, Gaw S, Choi K, Yamamoto H, Thatikonda S, Zhu Y-G, Carriquiriborde P (2014) Potential ecological footprints of active pharmaceutical ingredients: an examination of risk factors in low-, middle-and high-income countries. Phil Trans R Soc B 369:20130586

    Article  Google Scholar 

  • Kools SA, Boxall A, Moltmann JF, Bryning G, Koschorreck J, Knacker T (2008) A ranking of European veterinary medicines based on environmental risks. Integr Environ Assess Manag 4:399–408

    Article  CAS  Google Scholar 

  • Koutsogiannaki S, Evangelinos N, Koliakos G, Kaloyianni M (2006) Cytotoxic mechanisms of Zn2+ and Cd2+ involve Na+/H+ exchanger (NHE) activation by ROS. Aquat Toxicol 78:315–324

    Article  CAS  Google Scholar 

  • Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R, Chaudhary U, Doumith M, Giske CG, Irfan S (2010) Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10:597–602

    Article  CAS  Google Scholar 

  • Kümmerer K (2009) Antibiotics in the aquatic environment—a review—part I. Chemosphere 75:417–434

    Article  CAS  Google Scholar 

  • Lahti M, Brozinski J-M, Jylhä A, Kronberg L, Oikari A (2011) Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout. Environ Toxicol Chem 30:1403–1411

    Article  CAS  Google Scholar 

  • Lahti M, Brozinski JM, Segner H, Kronberg L, Oikari A (2012) Bioavailability of pharmaceuticals in waters close to wastewater treatment plants: use of fish bile for exposure assessment. Environ Toxicol Chem 31:1831–1837

    Article  CAS  Google Scholar 

  • Lalumera GM, Calamari D, Galli P, Castiglioni S, Crosa G, Fanelli R (2004) Preliminary investigation on the environmental occurrence and effects of antibiotics used in aquaculture in Italy. Chemosphere 54:661–668

    Article  CAS  Google Scholar 

  • Langford K, Thomas KV (2011) Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment. J Environ Monit 13:416–421

    Article  CAS  Google Scholar 

  • Lapworth D, Baran N, Stuart M, Ward R (2012) Emerging organic contaminants in groundwater: a review of sources, fate and occurrence. Environ Pollut 163:287–303

    Article  CAS  Google Scholar 

  • Lara-Martín PA, González-Mazo E, Petrovic M, Barceló D, Brownawell BJ (2014) Occurrence, distribution and partitioning of nonionic surfactants and pharmaceuticals in the urbanized Long Island Sound Estuary (NY). Mar Pollut Bull 85:710–719

    Article  CAS  Google Scholar 

  • Larsen J, Roney JM (2013) Farmed fish production overtakes beef. Earth Policy Institute, Washington, DC

    Google Scholar 

  • Le TX, Munekage Y (2004) Residues of selected antibiotics in water and mud from shrimp ponds in mangrove areas in Vietnam. Mar Pollut Bull 49:922–929

    Article  CAS  Google Scholar 

  • Le TX, Munekage Y, Kato S-I (2005) Antibiotic resistance in bacteria from shrimp farming in mangrove areas. Sci Total Environ 349:95–105

    Article  CAS  Google Scholar 

  • Lee WY, Arnold C (1983) Chronic toxicity of ocean-dumped pharmaceutical wastes to the marine amphipod Amphithoe valida. Mar Pollut Bull 14:150–153

    Article  CAS  Google Scholar 

  • Li H (2003) Management of coastal mega-cities—a new challenge in the 21st century. Marine Policy 27:333–337

    Article  Google Scholar 

  • Li W, Shi Y, Gao L, Liu J, Cai Y (2012) Investigation of antibiotics in mollusks from coastal waters in the Bohai Sea of China. Environ Pollut 162:56–62

    Article  CAS  Google Scholar 

  • Lin Y, Labbe R, Shetty K (2004) Inhibition of Listeria monocytogenes in fish and meat systems by use of oregano and cranberry phytochemical synergies. Appl Environ Microbiol 70:5672–5678

    Article  CAS  Google Scholar 

  • Long ER, Dutch M, Weakland S, Chandramouli B, Benskin JP (2013) Quantification of pharmaceuticals, personal care products, and perfluoroalkyl substances in the marine sediments of Puget Sound, Washington, USA. Environ Toxicol Chem 32:1701–1710

    Article  CAS  Google Scholar 

  • Love DC, Rodman S, Neff RA, Nachman KE (2011) Veterinary drug residues in seafood inspected by the European Union, United States, Canada, and Japan from 2000 to 2009. Environ Sci Technol 45:7232–7240

    Article  CAS  Google Scholar 

  • Luo Y, Guo W, Ngo HH, Nghiem LD, Hai FI, Zhang J, Liang S, Wang XC (2014) A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment. Sci Total Environ 473–474:619–641

    Article  CAS  Google Scholar 

  • Mahmoud BS, Yamazaki K, Miyashita K, Il-Shik S, Dong-Suk C, Suzuki T (2004) Bacterial microflora of carp (Cyprinus carpio) and its shelf-life extension by essential oil compounds. Food Microbiol 21:657–666

    Article  CAS  Google Scholar 

  • Maranho L, Baena-Nogueras R, Lara-Martín P, Delvalls T, Martín-Díaz M (2014) Bioavailability, oxidative stress, neurotoxicity and genotoxicity of pharmaceuticals bound to marine sediments. The use of the polychaete Hediste diversicolor as bioindicator species. Environ Res 134:353–365

    Article  CAS  Google Scholar 

  • Maranho L, Garrido-Pérez M, Baena-Nogueras R, Lara-Martín P, Antón-Martín R, Delvalls T, Martín-Díaz M (2015) Are WWTPs effluents responsible for acute toxicity? Seasonal variations of sediment quality at the Bay of Cádiz (SW, Spain). Ecotoxicology 24:368–380

    Article  CAS  Google Scholar 

  • Martin-Diaz L, Franzellitti S, Buratti S, Valbonesi P, Capuzzo A, Fabbri E (2009) Effects of environmental concentrations of the antiepilectic drug carbamazepine on biomarkers and cAMP-mediated cell signaling in the mussel Mytilus galloprovincialis. Aquat Toxicol 94:177–185

    Article  CAS  Google Scholar 

  • Martínez M, Intralawan A, Vázquez G, Pérez-Maqueo O, Sutton P, Landgrave R (2007) The coasts of our world: ecological, economic and social importance. Ecol Econ 63:254–272

    Article  Google Scholar 

  • Maruya KA, Vidal-Dorsch DE, Bay SM, Kwon JW, Xia K, Armbrust KL (2012) Organic contaminants of emerging concern in sediments and flatfish collected near outfalls discharging treated wastewater effluent to the Southern California Bight. Environ Toxicol Chem 31:2683–2688

    Article  CAS  Google Scholar 

  • Marzoug HNB, Romdhane M, Lebrihi A, Mathieu F, Couderc F, Abderraba M, Khouja ML, Bouajila J (2011) Eucalyptus oleosa essential oils: chemical composition and antimicrobial and antioxidant activities of the oils from different plant parts (stems, leaves, flowers and fruits). Molecules 16:1695–1709

    Article  CAS  Google Scholar 

  • Matozzo V, Franchi N, Ballarin L (2014) In vitro effects of the nonsteroidal anti-inflammatory drug, ibuprofen, on the immune parameters of the colonial ascidian Botryllus schlosseri. Toxicol In Vitro 28:778–783

    Article  CAS  Google Scholar 

  • McEneff G, Barron L, Kelleher B, Paull B, Quinn B (2014) A year-long study of the spatial occurrence and relative distribution of pharmaceutical residues in sewage effluent, receiving marine waters and marine bivalves. Sci Total Environ 476:317–326

    Article  CAS  Google Scholar 

  • McIntosh D, Cunningham M, Ji B, Fekete FA, Parry EM, Clark SE, Zalinger ZB, Gilg IC, Danner GR, Johnson KA (2008) Transferable, multiple antibiotic and mercury resistance in Atlantic Canadian isolates of Aeromonas salmonicida subsp. salmonicida is associated with carriage of an IncA/C plasmid similar to the Salmonella enterica plasmid pSN254. J Antimicrob Chemother 61:1221–1228

    Article  CAS  Google Scholar 

  • Mehinto AC, Hill EM, Tyler CR (2010) Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical Diclofenac in Rainbow trout (Oncorhynchus mykiss). Environ Sci Technol 44:2176–2182

    Article  CAS  Google Scholar 

  • Mejlholm O, Dalgaard P (2002) Antimicrobial effect of essential oils on the seafood spoilage micro-organism Photobacterium phosphoreum in liquid media and fish products. Lett Appl Microbiol 34:27–31

    Article  CAS  Google Scholar 

  • Merrifield DL, Dimitroglou A, Foey A, Davies SJ, Baker RT, Bøgwald J, Castex M, Ringø E (2010) The current status and future focus of probiotic and prebiotic applications for salmonids. Aquaculture 302:1–18

    Article  Google Scholar 

  • Mesquita SR, Guilhermino L, Guimarães L (2011) Biochemical and locomotor responses of Carcinus maenas exposed to the serotonin reuptake inhibitor fluoxetine. Chemosphere 85:967–976

    Article  CAS  Google Scholar 

  • Milan M, Pauletto M, Patarnello T, Bargelloni L, Marin MG, Matozzo V (2013) Gene transcription and biomarker responses in the clam Ruditapes philippinarum after exposure to ibuprofen. Aquat Toxicol 126:17–29

    Article  CAS  Google Scholar 

  • Minh TB, Leung HW, Loi IH, Chan WH, So MK, Mao JQ, Choi D, Lam JC, Zheng G, Martin M (2009) Antibiotics in the Hong Kong metropolitan area: ubiquitous distribution and fate in Victoria Harbour. Mar Pollut Bull 58:1052–1062

    Article  CAS  Google Scholar 

  • Montezinho LP, Mørk A, Duarte CB, Penschuck S, Geraldes CF, Castro MMC (2007) Effects of mood stabilizers on the inhibition of adenylate cyclase via dopamine D2-like receptors. Bipolar Disord 9:290–297

    Article  CAS  Google Scholar 

  • Na G, Fang X, Cai Y, Ge L, Zong H, Yuan X, Yao Z, Zhang Z (2013) Occurrence, distribution, and bioaccumulation of antibiotics in coastal environment of Dalian, China. Mar Pollut Bull 69:233–237

    Article  CAS  Google Scholar 

  • Nash CE (2003) Interactions of Atlantic salmon in the Pacific Northwest: VI. A synopsis of the risk and uncertainty. Fish Res 62:339–347

    Article  Google Scholar 

  • Navarrete P, Mardones P, Opazo R, Espejo R, Romero J (2008) Oxytetracycline treatment reduces bacterial diversity of intestinal microbiota of Atlantic salmon. J Aquat Anim Health 20:177–183

    Article  Google Scholar 

  • Neumann B, Vafeidis AT, Zimmermann J, Nicholls RJ (2015) Future coastal population growth and exposure to sea-level rise and coastal flooding-a global assessment. PLoS ONE 10:e0118571

    Article  CAS  Google Scholar 

  • Nichols JW, Du B, Berninger JP, Connors KA, Chambliss CK, Erickson RJ, Hoffman AD, Brooks BW (2015) Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, in fathead minnows. Environ Toxicol Chem 34:1425–1435

    Article  CAS  Google Scholar 

  • Nikaido H (2009) Multidrug resistance in bacteria. Annu Rev Biochem 78:119–146

    Article  CAS  Google Scholar 

  • Ninawe A, Selvin J (2009) Probiotics in shrimp aquaculture: avenues and challenges. Crit Rev Microbiol 35:43–66

    Article  CAS  Google Scholar 

  • Nödler K, Voutsa D, Licha T (2014) Polar organic micropollutants in the coastal environment of different marine systems. Mar Pollut Bull 85:50–59

    Article  CAS  Google Scholar 

  • OECD (2008) OECD guidelines for the testing of chemicals bioaccumulation in sediment-dwelling benthic oligochaetes. OECD Guideline

    Google Scholar 

  • Organisation I (2003) International convention for the prevention of pollution from ships (MARPOL), Annex IV prevention of pollution by sewage from ships [Online]. Accessed 10 July 2016

    Google Scholar 

  • Owen SF, Huggett DB, Hutchinson TH, Hetheridge MJ, Kinter LB, Ericson JF, Sumpter JP (2009) Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry. Aquat Toxicol 93:217–224

    Article  CAS  Google Scholar 

  • Pal A, Gin KY-H, Lin AY-C, Reinhard M (2010) Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. Sci Total Environ 408:6062–6069

    Article  CAS  Google Scholar 

  • Pal R, Megharaj M, Kirkbride KP, Naidu R (2013) Illicit drugs and the environment—a review. Sci Total Environ 463:1079–1092

    Article  CAS  Google Scholar 

  • Petrović M, Hernando MD, Díaz-Cruz MS, Barceló D (2005) Liquid chromatography–tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: a review. J Chromatogr A 1067:1–14

    Article  CAS  Google Scholar 

  • Petrovic M, Perez S, Barcelo D (2013) Analysis, removal, effects and risk of pharmaceuticals in the water cycle: occurrence and transformation in the environment. Elsevier, Cambridge. ISBN: 9780444626578

    Google Scholar 

  • Phan HV, Hai FI, McDonald JA, Khan SJ, van de Merwe JP, Leusch FDL, Zhang R, Price WE, Broeckmann A, Nghiem LD (2015) Impact of hazardous events on the removal of nutrients and trace organic contaminants by an anoxic–aerobic membrane bioreactor receiving real wastewater. Biores Technol 192:192–201

    Article  CAS  Google Scholar 

  • Pichon V (2000) Solid-phase extraction for multiresidue analysis of organic contaminants in water. J Chromatogr A 885:195–215

    Article  CAS  Google Scholar 

  • Pintado-Herrera MG, González-Mazo E, Lara-Martín PA (2013) Environmentally friendly analysis of emerging contaminants by pressurized hot water extraction—stir bar sorptive extraction—derivatization and gas chromatography—mass spectrometry. Anal Bioanal Chem 405:401–411

    Article  CAS  Google Scholar 

  • Pojana G, Gomiero A, Jonkers N, Marcomini A (2007) Natural and synthetic endocrine disrupting compounds (EDCs) in water, sediment and biota of a coastal lagoon. Environ Int 33:929–936

    Article  CAS  Google Scholar 

  • Pyrgotou N, Giatrakou V, Ntzimani A, Savvaidis IN (2010) Quality assessment of salted, modified atmosphere packaged rainbow trout under treatment with oregano essential oil. J Food Sci 75:M406–M411

    Article  CAS  Google Scholar 

  • Qi W, Müller B, Pernet-Coudrier B, Singer H, Liu H, Qu J, Berg M (2014) Organic micropollutants in the Yangtze River: seasonal occurrence and annual loads. Sci Total Environ 472:789–799

    Article  CAS  Google Scholar 

  • Rand-Weaver M, Margiotta-Casaluci L, Patel A, Panter GH, Owen SF, Sumpter JP (2013) The read-across hypothesis and environmental risk assessment of pharmaceuticals. Environ Sci Technol 47:11384–11395

    Article  CAS  Google Scholar 

  • Randrianarivelo R, Danthu P, Benoit C, Ruez P, Raherimandimby M, Sarter S (2010) Novel alternative to antibiotics in shrimp hatchery: effects of the essential oil of Cinnamosma fragrans on survival and bacterial concentration of Penaeus monodon larvae. J Appl Microbiol 109:642–650

    CAS  Google Scholar 

  • Rawn DF, Krakalovich T, Forsyth DS, Roscoe V (2009) Analysis of fin and non-fin fish products for azamethiphos and dichlorvos residues from the Canadian retail market. Int J Food Sci Technol 44:1510–1516

    Article  CAS  Google Scholar 

  • Richardson BJ, Lam PK, Martin M (2005) Emerging chemicals of concern: pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China. Mar Pollut Bull 50:913–920

    Article  CAS  Google Scholar 

  • Rico A, van den Brink PJ (2014) Probabilistic risk assessment of veterinary medicines applied to four major aquaculture species produced in Asia. Sci Total Environ 468:630–641

    Article  CAS  Google Scholar 

  • Robinson BJ, Hui JP, Soo EC, Hellou J (2009) Estrogenic compounds in seawater and sediment from Halifax Harbour, Nova Scotia, Canada. Environ Toxicol Chem 28:18–25

    Article  CAS  Google Scholar 

  • Rodríguez-Navas C, Björklund E, Bak SA, Hansen M, Krogh KA, Maya F, Forteza R, Cerdà V (2013) Pollution pathways of pharmaceutical residues in the aquatic environment on the island of Mallorca, Spain. Arch Environ Contam Toxicol 65:56–66

    Article  CAS  Google Scholar 

  • Romero J, Feijoó CG, Navarrete P (2012) Antibiotics in aquaculture-use, abuse and alternatives. In: Carvalho ED, David GS, Silva RJ (eds) Health and environment in aquaculture. INTECH Open Access Publisher, Rijeka. ISBN: 9789535104971

    Google Scholar 

  • Romero J, Navarrete P (2006) 16S rDNA-based analysis of dominant bacterial populations associated with early life stages of coho salmon (Oncorhynchus kisutch). Microb Ecol 51:422–430

    Article  CAS  Google Scholar 

  • Rose JM, Gast RJ, Bogomolni A, Ellis JC, Lentell BJ, Touhey K, Moore M (2009) Occurrence and patterns of antibiotic resistance in vertebrates off the Northeastern United States coast. FEMS Microbiol Ecol 67:421–431

    Article  CAS  Google Scholar 

  • Rosi-Marshall E, Snow D, Bartelt-Hunt SL, Paspalof A, Tank J (2015) A review of ecological effects and environmental fate of illicit drugs in aquatic ecosystems. J Hazard Mater 282:18–25

    Article  CAS  Google Scholar 

  • Roth M, Richards R, Sommerville C (1993) Current practices in the chemotherapeutic control of sea lice infestations in aquaculture: a review. J Fish Dis 16:1–26

    Article  CAS  Google Scholar 

  • Roy W, Sutherland I, Rodger H, Varma K (2000) Tolerance of Atlantic salmon, Salmo salar L., and rainbow trout, Oncorhynchus mykiss (Walbaum), to emamectin benzoate, a new orally administered treatment for sea lice. Aquaculture 184:19–29

    Article  CAS  Google Scholar 

  • Ryu S-H, Park S-G, Choi S-M, Hwang Y-O, Ham H-J, Kim S-U, Lee Y-K, Kim M-S, Park G-Y, Kim K-S (2012) Antimicrobial resistance and resistance genes in Escherichia coli strains isolated from commercial fish and seafood. Int J Food Microbiol 152:14–18

    Article  CAS  Google Scholar 

  • Santos LH, Araújo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro M (2010) Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 175:45–95

    Article  CAS  Google Scholar 

  • Santos N, Medina W, Martins N, Rodrigues MC, Curti C, Santos A (2008) Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs. Toxicol In Vitro 22:1820–1824

    Article  CAS  Google Scholar 

  • Sarmah AK, Meyer MT, Boxall AB (2006) A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65:725–759

    Article  CAS  Google Scholar 

  • Schmitt H, Boucard T, Garric J, Jensen J, Parrott J, Pery A, Rombke J, Straub JO, Hutchinson TH, Sanchez-Arguello P, Wennmalm A, Duis K (2010) Recommendations on the environmental risk assessment of pharmaceuticals: effect characterization. Integr Environ Assess Manag 6(Suppl):588–602

    CAS  Google Scholar 

  • Schulze AD, Alabi AO, Tattersall-Sheldrake AR, Miller KM (2006) Bacterial diversity in a marine hatchery: balance between pathogenic and potentially probiotic bacterial strains. Aquaculture 256:50–73

    Article  Google Scholar 

  • Semblante GU, Hai FI, Huang X, Ball AS, Price WE, Nghiem LD (2015) Trace organic contaminants in biosolids: impact of conventional wastewater and sludge processing technologies and emerging alternatives. J Hazard Mater 300:1–17

    Article  CAS  Google Scholar 

  • Shenker M, Harush D, Ben-Ari J, Chefetz B (2011) Uptake of carbamazepine by cucumber plants—a case study related to irrigation with reclaimed wastewater. Chemosphere 82:905–910

    Article  CAS  Google Scholar 

  • Shpakov A, Shipilov V, Bondareva V (2005) Sensitivity of adenylyl cyclase signaling system of the mollusk Anodonta cygnea ganglions to serotonin and adrenergic agonists. Ann N Y Acad Sci 1040:466–468

    Article  CAS  Google Scholar 

  • Small C, Nicholls RJ (2003) A global analysis of human settlement in coastal zones. J Coast Res, 584–599

    Google Scholar 

  • Smith P (2008) Antimicrobial resistance in aquaculture. Rev Sci Tech 27:243–264

    Article  CAS  Google Scholar 

  • Smith P, Christofilogiannis P (2007) Application of normalised resistance interpretation to the detection of multiple low-level resistance in strains of Vibrio anguillarum obtained from Greek fish farms. Aquaculture 272:223–230

    Article  CAS  Google Scholar 

  • Solé M, Shaw JP, Frickers PE, Readman JW, Hutchinson TH (2010) Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen. Anal Bioanal Chem 396:649–656

    Article  CAS  Google Scholar 

  • Son S, Wang M, Shon J-K (2011) Satellite observations of optical and biological properties in the Korean dump site of the Yellow Sea. Remote Sens Environ 115:562–572

    Article  Google Scholar 

  • Spongberg AL, Witter JD, Acuna J, Vargas J, Murillo M, Umana G, Gomez E, Perez G (2011) Reconnaissance of selected PPCP compounds in Costa Rican surface waters. Water Res 45:6709–6717

    Article  CAS  Google Scholar 

  • Stewart M, Olsen G, Hickey CW, Ferreira B, Jelić A, Petrović M, Barcelo D (2014) A survey of emerging contaminants in the estuarine receiving environment around Auckland, New Zealand. Sci Total Environ 468:202–210

    Article  CAS  Google Scholar 

  • Taylor NG, Verner-Jeffreys DW, Baker-Austin C (2011) Aquatic systems: maintaining, mixing and mobilising antimicrobial resistance? Trends Ecol Evol 26:278–284

    Article  Google Scholar 

  • Teo JW, Suwanto A, Poh CL (2000) Novel β-lactamase genes from two environmental isolates of Vibrio harveyi. Antimicrob Agents Chemother 44:1309–1314

    Article  CAS  Google Scholar 

  • Tinh NTN, Dierckens K, Sorgeloos P, Bossier P (2008) A review of the functionality of probiotics in the larviculture food chain. Mar Biotechnol 10:1–12

    Article  CAS  Google Scholar 

  • Todar K (2002) Antimicrobial agents used in the treatment of infectious disease. Department of Bacteriology, University of Wisconsin-Madison, Madison

    Google Scholar 

  • Trautwein C, Berset J-D, Wolschke H, Kümmerer K (2014) Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle. Environ Int 70:203–212

    Article  CAS  Google Scholar 

  • Vanderford BJ, Snyder SA (2006) Analysis of pharmaceuticals in water by isotope dilution liquid chromatography/tandem mass spectrometry. Environ Sci Technol 40:7312–7320

    Article  CAS  Google Scholar 

  • Vanneste J (2013) Recent progress on detecting, understanding and controlling Pseudomonas syringae pv. actinidiae: a short review. NZ Plant Prot 66:170–177

    CAS  Google Scholar 

  • Verlicchi P, Al Aukidy M, Zambello E (2012) Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment—a review. Sci Total Environ 429:123–155

    Google Scholar 

  • Viarengo A, Lowe D, Bolognesi C, Fabbri E, Koehler A (2007) The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms. Comp Biochem Physiol C: Toxicol Pharmacol 146:281–300

    CAS  Google Scholar 

  • Waddy S, Burridge L, Hamilton M, Mercer S, Aiken D, Haya K (2002) Rapid communication/communication rapide emamectin benzoate induces molting in American lobster, Homarus americanus. Can J Fish Aquat Sci 59:1096–1099

    Article  CAS  Google Scholar 

  • Waddy S, Merritt V, Hamilton-Gibson M, Aiken D, Burridge L (2007) Relationship between dose of emamectin benzoate and molting response of ovigerous American lobsters (Homarus americanus). Ecotoxicol Environ Saf 67:95–99

    Article  CAS  Google Scholar 

  • Wang G, Ma P, Zhang Q, Lewis J, Lacey M, Furukawa Y, O’Reilly SE, Meaux S, McLachlan J, Zhang S (2012) Endocrine disrupting chemicals in New Orleans surface waters and Mississippi Sound sediments. J Environ Monit 14:1353–1364

    Article  CAS  Google Scholar 

  • Wang J, Gardinali PR (2013) Uptake and depuration of pharmaceuticals in reclaimed water by mosquito fish (Gambusia holbrooki): a worst-case, multiple-exposure scenario. Environ Toxicol Chem 32:1752–1758

    Article  CAS  Google Scholar 

  • Wijekoon KC, Hai FI, Kang J, Price WE, Guo W, Ngo HH, Nghiem LD (2013) The fate of pharmaceuticals, steroid hormones, phytoestrogens, UV-filters and pesticides during MBR treatment. Biores Technol 144:247–254

    Article  CAS  Google Scholar 

  • Xu Y, Nguyen TV, Reinhard M, Gin KY-H (2011) Photodegradation kinetics of p-tert-octylphenol, 4-tert-octylphenoxy-acetic acid and ibuprofen under simulated solar conditions in surface water. Chemosphere 85:790–796

    Article  CAS  Google Scholar 

  • Yang S, Hai FI, Nghiem LD, Nguyen LN, Roddick F, Price WE (2013a) Removal of bisphenol A and diclofenac by a novel fungal membrane bioreactor operated under non-sterile conditions. Int Biodeterior Biodegradation 85:483–490

    Article  CAS  Google Scholar 

  • Yang S, Hai FI, Nghiem LD, Price WE, Roddick F, Moreira MT, Magram SF (2013b) Understanding the factors controlling the removal of trace organic contaminants by white-rot fungi and their lignin modifying enzymes: a critical review. Biores Technol 141:97–108

    Article  CAS  Google Scholar 

  • Yu Y, Wu L (2012) Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography—mass spectrometry. Talanta 89:258–263

    Article  CAS  Google Scholar 

  • Zenker A, Cicero MR, Prestinaci F, Bottoni P, Carere M (2014) Bioaccumulation and biomagnification potential of pharmaceuticals with a focus to the aquatic environment. J Environ Manage 133:378–387

    Article  CAS  Google Scholar 

  • Zhang X, Gao Y, Li Q, Li G, Guo Q, Yan C (2011) Estrogenic compounds and estrogenicity in surface water, sediments, and organisms from Yundang Lagoon in Xiamen, China. Arch Environ Contam Toxicol 61:93–100

    Article  CAS  Google Scholar 

  • Zheng Q, Zhang R, Wang Y, Pan X, Tang J, Zhang G (2012) Occurrence and distribution of antibiotics in the Beibu Gulf, China: impacts of river discharge and aquaculture activities. Mar Environ Res 78:26–33

    Article  CAS  Google Scholar 

  • Zheng S, Qiu X, Chen B, Yu X, Liu Z, Zhong G, Li H, Chen M, Sun G, Huang H (2011) Antibiotics pollution in Jiulong River estuary: source, distribution and bacterial resistance. Chemosphere 84:1677–1685

    Article  CAS  Google Scholar 

  • Zhou X-X, Wang Y-B, Li W-F (2009) Effect of probiotic on larvae shrimp (Penaeus vannamei) based on water quality, survival rate and digestive enzyme activities. Aquaculture 287:349–353

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Strategic Water Infrastructure Laboratory, School of Civil, Mining and Environmental Engineering, University of Wollongong, Wollongong, NSW, 2522, Australia

    Muhammad B. Asif, Faisal I. Hai & Long D. Nghiem

  2. Strategic Water Infrastructure Laboratory, School of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia

    William E. Price

Authors
  1. Muhammad B. Asif
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Faisal I. Hai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. William E. Price
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Long D. Nghiem
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Faisal I. Hai .

Editor information

Editors and Affiliations

  1. Faculty of Engineering and Information Sciences, University of Wollongong, Wollongong, New South Wales, Australia

    Faisal I. Hai

  2. Asian Institute of Technology, Klongluang Pathumthani, Thailand

    Chettiyappan Visvanathan

  3. Nicholls State University, Thibodaux, Louisiana, USA

    Ramaraj Boopathy

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Asif, M.B., Hai, F.I., Price, W.E., Nghiem, L.D. (2018). Impact of Pharmaceutically Active Compounds in Marine Environment on Aquaculture. In: Hai, F., Visvanathan, C., Boopathy, R. (eds) Sustainable Aquaculture. Applied Environmental Science and Engineering for a Sustainable Future. Springer, Cham. https://doi.org/10.1007/978-3-319-73257-2_9

Download citation

Publish with us

Policies and ethics

Search

Navigation