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Sleep Issues in Pediatric Neuromuscular Disorders

  • Raja Boddepalli
  • Raghav GovindarajanEmail author
Chapter

Abstract

The clinical effects surfacing with either hereditary or nonhereditary neuromuscular disorders (NMD) in children have significant impact in terms of morbidity and mortality. Furthermore, the resulting neuromuscular weaknesses of these disorders predispose to sleep-related breathing disorders (SRBD) such as obstructive sleep apnea syndrome (OSAS), hypoventilation, and central sleep apnea. SRBD are very common in neuromuscular disorders and are often overlooked and misdiagnosed. Besides, NMD and OSAS are both prevalent disorders that overlap, thereby making it more challenging in delineating one from the other in deriving its etiology. SRBD become more prominent, severe, and persistent with the progression of underlying NMD. The effects of SRBD on cognition, learning, behavior, and respiratory status demonstrably influence their neurological functioning and quality of life. The strategies in creating awareness and early recognition of these patients benefit in identification of sleep problems and associated SRBD, respiratory complications. Besides, it aids in initiation of early treatment and thereby optimizing quality of life. We review SRBD in children with various NMD, along with assessment tools for early recognition and appropriate cost-effective therapies for treatment.

Keywords

Pediatric neuromuscular disorders Hypoventilation Non-invasive positive pressure ventilation Muscular dystrophy Spinal muscular atrophy Myotonic dystrophy Limb-girdle muscular dystrophy 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Academic DepartmentStony Brook University School of MedicineStony BrookUSA
  2. 2.Department of NeurologyUniversity of MissouriColumbiaUSA

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