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Sleep Issues in Pediatric Neuromuscular Disorders

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Sleep Issues in Neuromuscular Disorders

Abstract

The clinical effects surfacing with either hereditary or nonhereditary neuromuscular disorders (NMD) in children have significant impact in terms of morbidity and mortality. Furthermore, the resulting neuromuscular weaknesses of these disorders predispose to sleep-related breathing disorders (SRBD) such as obstructive sleep apnea syndrome (OSAS), hypoventilation, and central sleep apnea. SRBD are very common in neuromuscular disorders and are often overlooked and misdiagnosed. Besides, NMD and OSAS are both prevalent disorders that overlap, thereby making it more challenging in delineating one from the other in deriving its etiology. SRBD become more prominent, severe, and persistent with the progression of underlying NMD. The effects of SRBD on cognition, learning, behavior, and respiratory status demonstrably influence their neurological functioning and quality of life. The strategies in creating awareness and early recognition of these patients benefit in identification of sleep problems and associated SRBD, respiratory complications. Besides, it aids in initiation of early treatment and thereby optimizing quality of life. We review SRBD in children with various NMD, along with assessment tools for early recognition and appropriate cost-effective therapies for treatment.

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Suggested Reading

  • Aboussouan LS. Sleep-disordered breathing in neuromuscular disease. Am J Respir Crit Care Med. 2015;191(9):979–89.

    Article  Google Scholar 

  • Alves RSC, Resende MBD, Skomro RP, Souza FJFB, Reed UC. Sleep and neuromuscular disorders in children. Sleep Med Rev. 2009;13(2):133–48.

    Article  Google Scholar 

  • American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am J Respir Crit Care Med. 1996;153(2):866–78.

    Article  Google Scholar 

  • Arens R, Muzumdar H. Sleep, sleep disordered breathing, and nocturnal hypoventilation in children with neuromuscular diseases. Pediatr Respir Rev. 2010;11(1):24–30.

    Article  Google Scholar 

  • Aurora RN, Zak RS, Karippot A, et al. Practice parameters for the respiratory indications for polysomnography in children. Sleep. 2011;34(3):379–88.

    Article  Google Scholar 

  • Brouillette RT, Morielli A, Leimanis A, et al. Nocturnal pulse oximetry as an abbreviated testing modality for pediatric obstructive sleep apnea. Pediatrics. 2000;105:405–12.

    Article  CAS  Google Scholar 

  • Buu MC. Respiratory complications, management and treatments for neuromuscular disease in children. Curr Opin Pediatr. 2017;29(3):326–33.

    Article  Google Scholar 

  • Castro-Codesal ML, Dehaan K, Featherstone R, Bedi PK, Martinez Carrasco C, Katz SL, Chan EY, Bendiak GN, Almeida FR, Olmstead DL, Young R, Woolf V, Waters KA, Sullivan C, Hartling L, MacLean JE. Long-term non-invasive ventilation therapies in children: a scoping review. Sleep Med Rev. 2017;37:148–58.

    Article  Google Scholar 

  • Chervin RD, Hedger K, Dillon JE, Pituch KJ. Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med. 2000;1(1):21–32.

    Article  CAS  Google Scholar 

  • Clinical indications for noninvasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease, COPD, and nocturnal hypoventilation: a consensus conference report. Chest. 1999; 116(2):521–34.

    Google Scholar 

  • Dorris L, et al. Sleep problems in children with neurological disorders. Dev Neurorehabil. 2008;11(2):95–114.

    Article  Google Scholar 

  • Frates RC, Splaingard ML, Smith EO, Harrison GM. Outcome of home mechanical ventilation in children. J Pediatr. 1985;106(5):850–6.

    Article  Google Scholar 

  • Gonzalez Cortés R, Bustinza Arriortua A, Pons Ódena M, García Teresa MA, Cols Roig M, Gaboli M, et al. Domiciliary mechanical ventilation in children: a Spanish multicenter study. An Pediatr. 2013;78(4):227e33.

    Article  Google Scholar 

  • Guilleminault C, Philip P, Robinson A. Sleep and neuromuscular disease: bilevel positive airway pressure by nasal mask as a treatment for sleep disordered breathing in patients with neuromuscular disease. J Neurol Neurosurg Psychiatry. 1998;65(2):225–32.

    Article  CAS  Google Scholar 

  • Ho G, Widger J, Cardamone M, Farrar MA. Quality of life and excessive daytime sleepiness in children and adolescents with myotonic dystrophy type 1. Sleep Med. 2017;32:92–6.

    Article  Google Scholar 

  • Hukins CA, Hillman DR. Daytime predictors of sleep hypoventilation in Duchenne muscular dystrophy. Am J Respir Crit Care Med. 2000;161:166–70.

    Article  CAS  Google Scholar 

  • ICSD-2. The international classification of sleep disorders, diagnostic and coding manual. 2nd ed. Westchester, IL: AASM; 2005. p. 74e6. [EUA. P. Hauri, Task Force Chair]

    Google Scholar 

  • Katz SL. Assessment of sleep-disordered breathing in pediatric neuromuscular diseases. Pediatrics. 2009;123(Suppl4):S222–5.

    Article  Google Scholar 

  • Katz ES, Greene MG, Carson KA, Galster P, Loughlin GM, Carroll J, et al. Night-to-night variability of polysomnography in children with suspected obstructive sleep apnea. J Pediatr. 2002;140(5):589–94.

    Article  Google Scholar 

  • Katz S, Selvadurai H, Keilty K, Mitchell M, MacLusky I. Outcome of non-invasive positive pressure ventilation in paediatric neuromuscular disease. Arch Dis Child. 2004;89(2):121–4.

    Article  CAS  Google Scholar 

  • Kirk VG, Flemons WW, Adams C, Rimmer KP, Montgomery MD. Sleep-disordered breathing in duchenne muscular dystrophy: a preliminary study of the role of portable monitoring. Pediatr Pulmonol. 2000;29:135–40.

    Article  CAS  Google Scholar 

  • Labanowski M, Schmidt-Nowara W, Guilleminault C. Sleep and neuromuscular disease: frequency of sleep-disordered breathing in a neuromuscular disease clinic population. Neurology. 1996;47(5):1173–80.

    Article  CAS  Google Scholar 

  • Marcus CL. Sleep-disordered breathing in children. Am J Respir Crit Care Med. 2001;164(1):16–30.

    Article  CAS  Google Scholar 

  • Mellies U, Ragette R, Schwake C, Boehm H, Voit T, Teschler H. Daytime predictors of sleep disordered breathing in children and adolescents with neuromuscular disorders. Neuromuscul Disord. 2003;13:123e8.

    Article  Google Scholar 

  • Mellies U, Dohna-Schwake C, Stehling F, Voit T. Sleep disordered breathing in spinal muscular atrophy. Neuromuscul Disord. 2004;14(12):797–803.

    Article  Google Scholar 

  • Messner AH, Pelayo R. Pediatric sleep-related breathing disorders. Am J Otolaryngol. 2000;21(2):98–107. Review

    Article  CAS  Google Scholar 

  • Mindell JA, Owens JA. A clinical guide to pediatric sleep: diagnosis and management of sleep problems. Philadelphia: Lippincott Williams & Wilkins; 2015.

    Google Scholar 

  • Panitch HB. Respiratory issues in the management of children with neuromuscular disease. Respir Care. 2006;51(8):885e93.

    Google Scholar 

  • Piper AJ, Sullivan CE. Effects of long-term nocturnal nasal ventilation on spontaneous breathing during sleep in neuromuscular and chest wall disorders. Eur Respir J. 1996;9(7):1515–22.

    Article  CAS  Google Scholar 

  • Practice parameters for the indications for polysomnography and related Procedures. Polysomnography Task Force, American Sleep Disorders Association Standards of Practice Committee. Sleep. 1997;20(6):406–22. (No authors Listed).

    Google Scholar 

  • Ragette R, Mellies U, Schwake C, Voit T, Teschler H. Patterns and predictors of sleep disordered breathing in primary myopathies. Thorax. 2002;57(8):724e8.

    Article  Google Scholar 

  • Suresh S, Wales P, Dakin C, Harris MA, Cooper DG. Sleep-related breathing disorder in Duchenne muscular dystrophy: disease spectrum in the paediatric population. J Paediatr Child Health. 2005;41:500e3.

    Article  Google Scholar 

  • Teague WG. Non-invasive positive pressure ventilation: current status in paediatric patients. Paediatr Respir Rev. 2005;6(1):52–60.

    Article  Google Scholar 

  • Thorpy MJ. Classification of sleep disorders. Neurotherapeutics. 2012;9(4):687–701.

    Article  Google Scholar 

  • Wise MS, Nichols CD, et al. Executive summary of respiratory indications for polysomnography in children: an evidence-based review. Sleep. 2011;34(3):389–398AW.

    Article  Google Scholar 

  • Young HK, Lowe A, Fitzgerald DA, Seton C, Waters KA, Kenny E, Hynan LS, Iannaccone ST, North KN, Ryan MM. Outcome of noninvasive ventilation in children with neuromuscular disease. Neurology. 2007;68(3):198–201.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Academic Department, Stony Brook University School of Medicine, Stony Brook, NY, USA

    Raja Boddepalli M.D.

  2. Department of Neurology, University of Missouri, Columbia, MO, USA

    Raghav Govindarajan M.D., F.A.A.N.

Authors
  1. Raja Boddepalli M.D.
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  2. Raghav Govindarajan M.D., F.A.A.N.
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Correspondence to Raghav Govindarajan M.D., F.A.A.N. .

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Editors and Affiliations

  1. Department of Neurology, University of Missouri, Columbia, Missouri, USA

    Raghav Govindarajan

  2. Department of Neurology, University of Missouri , Columbia, Missouri, USA

    Pradeep C. Bollu

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Boddepalli, R., Govindarajan, R. (2018). Sleep Issues in Pediatric Neuromuscular Disorders. In: Govindarajan, R., Bollu, P. (eds) Sleep Issues in Neuromuscular Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-73068-4_7

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  • DOI: https://doi.org/10.1007/978-3-319-73068-4_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-73067-7

  • Online ISBN: 978-3-319-73068-4

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