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Sleep Issues in Motor Neuron Diseases

  • Sushma Yerram
  • Pradeep C. Bollu
  • Pradeep Sahota
Chapter

Abstract

Motor neuron diseases (MND) are progressive neuromuscular disorders that affect lower motor neurons and sometimes, upper motor neurons. Some of the MNDs manifest early in life while some develop later. Sleep disordered breathing (SDB) is a very common association in these diseases and can present as sleep apnea or hypoventilation. Untreated, SDB contributes to morbidity and reduced quality of life. In this chapter, we discuss the different types of MNDs and then about the associated sleep issues in these disorders. Early recognition of these associated sleep disorders and appropriate therapeutic intervention is the key to improve quality of life and reduce morbidity and mortality in these patients.

Keywords

Spinal muscular atrophy Amyotrophic lateral sclerosis Sleep-related hypoventilation Pulmonary function tests Sniff nasal inspiratory pressure Respiratory failure 

Abbreviations

AHI

Apnea hypopnea index

ALS

Amyotrophic lateral sclerosis

LOSMoN

Late onset spinal motor neuronopathy

MA

Monomelic amyotrophy

NIV

Noninvasive ventilation

NREM

Non-rapid eye movement

OSA

Obstructive sleep apnea

PLMS

Periodic leg movements in sleep

PLS

Primary lateral sclerosis

PMA

Progressive muscular atrophy

PSG

Polysomnogram

REM

Rapid eye movement

RERA

Respiratory effort-related arousals

RLS

Restless leg syndrome

SDB

Sleep disordered breathing

SMA

Spinal muscular atrophy

SMA-LED

SMA with lower extremity predominance

SMN

Survival motor neuron

SNIP

Sniff nasal inspiratory pressure

SPSMA

Scapuloperoneal SMA

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Sushma Yerram
    • 1
  • Pradeep C. Bollu
    • 2
  • Pradeep Sahota
    • 2
  1. 1.Department of NeurologyUniversity of RochesterRochesterUSA
  2. 2.Department of NeurologyUniversity of MissouriColumbiaUSA

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