Sleep Issues in Motor Neuron Diseases

  • Sushma Yerram
  • Pradeep C. BolluEmail author
  • Pradeep Sahota


Motor neuron diseases (MND) are progressive neuromuscular disorders that affect lower motor neurons and sometimes, upper motor neurons. Some of the MNDs manifest early in life while some develop later. Sleep disordered breathing (SDB) is a very common association in these diseases and can present as sleep apnea or hypoventilation. Untreated, SDB contributes to morbidity and reduced quality of life. In this chapter, we discuss the different types of MNDs and then about the associated sleep issues in these disorders. Early recognition of these associated sleep disorders and appropriate therapeutic intervention is the key to improve quality of life and reduce morbidity and mortality in these patients.


Spinal muscular atrophy Amyotrophic lateral sclerosis Sleep-related hypoventilation Pulmonary function tests Sniff nasal inspiratory pressure Respiratory failure 



Apnea hypopnea index


Amyotrophic lateral sclerosis


Late onset spinal motor neuronopathy


Monomelic amyotrophy


Noninvasive ventilation


Non-rapid eye movement


Obstructive sleep apnea


Periodic leg movements in sleep


Primary lateral sclerosis


Progressive muscular atrophy




Rapid eye movement


Respiratory effort-related arousals


Restless leg syndrome


Sleep disordered breathing


Spinal muscular atrophy


SMA with lower extremity predominance


Survival motor neuron


Sniff nasal inspiratory pressure


Scapuloperoneal SMA


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Sushma Yerram
    • 1
  • Pradeep C. Bollu
    • 2
    Email author
  • Pradeep Sahota
    • 2
  1. 1.Department of NeurologyUniversity of RochesterRochesterUSA
  2. 2.Department of NeurologyUniversity of MissouriColumbiaUSA

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