The ESCMID Study Group for Clostridium difficile: History, Role and Perspectives

  • John E. Coia
  • Ed J. Kuijper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1050)


C. difficile is a major nosocomial pathogen, but is also increasingly recognised as an important diarrhoeal pathogen in the community, not always associated with antibiotics. The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Clostridium difficile (ESGCD) is a group of clinicians and scientists from many European countries and further afield, who share a common interest in C. difficile. The aims of the Study Group are centred around raising the profile of CDI in humans and animals, fostering collaboration amongst centres in different European countries and providing a forum for discussing and disseminating information. One of the principal aims of the Study Group is to raise awareness of C. difficile infections in European hospitals. ESGCD has a particular interest in the development and dissemination of European guidance on prevention, diagnosis and treatment of CDI. This chapter will discuss the organisation of ESGCD within the ESCMID Study Group structure, the origins of the Study Group, the aims and objectives of the group, and will highlight some of the past and present activities of ESGCD in relation to these.


C. difficile research ESCMID Research projects C. difficile guidelines  



The authors wish to thank Jon Brazier, Michel Delmeé, Ian Poxton and Henri Saenz for their assistance in the development of this manuscript. They also particularly wish to thank ESCMID for the ongoing support of, and commitment to, the work of ESGCD.


  1. Barbut F, Delmee M, Brazier JS et al (2003) A European survey of diagnostic methods and testing protocols for Clostridium difficile. Clin Microbiol Infect 9(10):989–996CrossRefGoogle Scholar
  2. Barbut F, Mastrantonio P, Delmee M et al (2007) Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterisation of the isolates. Clin Microbiol Infect 13(11):1048–1057. CrossRefGoogle Scholar
  3. Bauer MP, Kuijper EJ, van Dissel JT (2009) European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI). Clin Microbiol Infect 15(12):1067–1079. CrossRefGoogle Scholar
  4. Bauer MP, Notermans DW, van Benthem BH et al (2011) Clostridium difficile infection in Europe: a hospital-based survey. Lancet 377(9759):63–73. CrossRefGoogle Scholar
  5. Crobach MJ, Dekkers OM, Wilcox MH et al (2009) European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect 15(12):1053–1066. CrossRefGoogle Scholar
  6. Crobach MJ, Planche T, Eckert C et al (2016) European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection. Clin Microbiol Infect 22(Suppl 4):S63–S81. CrossRefGoogle Scholar
  7. Davies KA, Ashwin H, Longshaw CM et al (2016) Diversity of Clostridium difficile PCR ribotypes in Europe: results from the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID), 2012 and 2013. Euro Surveill 21(29.)
  8. Debast SB, Bauer MP, Kuijper EJ (2014) European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin Microbiol Infect 20(Suppl 2):1–26. CrossRefGoogle Scholar
  9. E CDC (2017) ECDC surveillance protocol for CDI. Accessed 4 Aug 2017
  10. ECDIS-net (2017) ECDIS-net home page. Accessed 4 Aug 2017
  11. ESCMID (2017a) ECCMID 2017 wrap-up. ESCMID. Accessed 9 Jul 2017
  12. Honda H, Dubberke ER (2014) The changing epidemiology of Clostridium difficile infection. Curr Opin Gastroenterol 30(1):54–62. CrossRefGoogle Scholar
  13. Knetsch CW, Connor TR, Mutreja A et al (2014) Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011. Euro Surveill 19(45):20954CrossRefGoogle Scholar
  14. Knight DR, Squire MM, Collins DA et al (2016) Genome analysis of Clostridium difficile PCR ribotype 014 lineage in Australian pigs and humans reveals a diverse genetic repertoire and signatures of long-range interspecies transmission. Front Microbiol 7:2138. Google Scholar
  15. Kola A, Wiuff C, Akerlund T et al (2016) Survey of Clostridium difficile infection surveillance systems in Europe, 2011. Euro Surveill 21(29.)
  16. Krutova M, Matejkova J, Kuijper EJ et al (2016a) Clostridium difficile PCR ribotypes 001 and 176 – the common denominator of C. difficile infection epidemiology in the Czech Republic, 2014. Euro Surveill 21(29.)
  17. Krutova M, Nyc O, Matejkova J et al (2016b) Molecular characterisation of Czech Clostridium difficile isolates collected in 2013–2015. Int J Med Microbiol 306(7):479–485. CrossRefGoogle Scholar
  18. Kuijper EJ, Coignard B, Tull P et al (2006) Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 12(Suppl 6):2–18. CrossRefGoogle Scholar
  19. Larson HE, Price AB, Honour P et al (1978) Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet 1(8073):1063–1066CrossRefGoogle Scholar
  20. Nyc O, Tejkalova R, Kriz Z et al (2017) Two clusters of fluoroquinolone and clindamycin-resistant Clostridium difficile PCR ribotype 001 strain recognized by capillary electrophoresis ribotyping and multilocus variable tandem repeat analysis. Microb Drug Resist 23(5):609–615. CrossRefGoogle Scholar
  21. Phillips I (2008) ESCMID news supplement to issue number 1/2008Google Scholar
  22. Smits WK, Lyras D, Lacy DB et al (2016) Clostridium difficile infection. Nat Rev Dis Prim 2:16020–16020. Scholar
  23. Terveer EM, van Beurden YH, Goorhuis A et al (2017) How to: establish and run a stool bank. Clin Microbiol Infect 23(12):924–930. CrossRefGoogle Scholar
  24. van Dorp SM, Kinross P, Gastmeier P et al (2016a) Standardised surveillance of Clostridium difficile infection in European acute care hospitals: a pilot study, 2013. Euro Surveill 21(29).
  25. van Dorp SM, Notermans DW, Alblas J et al (2016b) Survey of diagnostic and typing capacity for Clostridium difficile infection in Europe, 2011 and 2014. Euro Surveill 21(29).
  26. Vonberg RP, Kuijper EJ, Wilcox MH et al (2008) Infection control measures to limit the spread of Clostridium difficile. Clin Microbiol Infect 14(Suppl 5):2–20. CrossRefGoogle Scholar
  27. Warny M, Pepin J, Fang A et al (2005) Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 366(9491):1079–1084. CrossRefGoogle Scholar
  28. Widmer AF, Frei R, Erb S et al (2017) Transmissibility of Clostridium difficile without contact isolation: results from a prospective observational study with 451 patients. Clin Infect Dis 64(4):393–400. PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Scottish Microbiology Reference LaboratoriesGlasgowUK
  2. 2.ESCMID Study Group for C.difficile (ESGCD)BaselSwitzerland
  3. 3.Department of Medical Microbiology, Center of Infectious DiseasesLeiden University Medical CenterLeidenThe Netherlands

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