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Economic Burden of Clostridium difficile Infection in European Countries

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Updates on Clostridium difficile in Europe

Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 1050))

Abstract

Clostridium difficile infection (CDI) remains a considerable challenge to health care systems worldwide. Although CDI represents a significant burden on healthcare systems in Europe, few studies have attempted to estimate the consumption of resources associated with CDI in Europe. The reported extra costs attributable to CDI vary widely according to the definitions, design, and methodologies used, making comparisons difficult to perform. In this chapter, the economic burden of healthcare facility–associated CDI in Europe will be assessed, as will other less explored areas such as the economic burden of recurrent CDI, community-acquired CDI, pediatric CDI, and CDI in outbreaks.

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References

  • Al-Eidan FA, McElnay JC, Scott MG, Kearney MP (2000) Clostridium difficile-associated diarrhoea in hospitalised patients. J Clin Pharm Ther 25(2):101–109

    Article  CAS  Google Scholar 

  • Asensio A, Bouza E, Grau S, Rubio-Rodriguez D, Rubio-Terres C (2013) Cost of Clostridium difficile associated diarrhea in Spain. Rev Esp Salud Publica 87(1):25–33. https://doi.org/10.4321/s1135-57272013 000100004

  • Asensio A, Di Bella S, Lo Vecchio A, Grau S, Hart WM, Isidoro B, Scotto R, Petrosillo N, Watt M, Nazir J (2015) The impact of Clostridium difficile infection on resource use and costs in hospitals in Spain and Italy: a matched cohort study. Int J Infect Dis 36:31–38. https://doi.org/10.1016/j.ijid.2015.05.013

    Article  PubMed  Google Scholar 

  • Barbut F (2015) How to eradicate Clostridium difficile from the environment. J Hosp Infect 89(4):287–295. https://doi.org/10.1016/j.jhin.2014.12.007

    Article  CAS  PubMed  Google Scholar 

  • Barbut F, Jones G, Eckert C (2011) Epidemiology and control of Clostridium difficile infections in healthcare settings: an update. Curr Opin Infect Dis 24(4):370–376. https://doi.org/10.1097/QCO.0b013e32 834748e5

    Article  Google Scholar 

  • Bouza E (2012) Consequences of Clostridium difficile infection: understanding the healthcare burden. Clin Microbiol Infect 18(Suppl 6):5–12. https://doi.org/10.1111/1469-0691.12064

    Article  PubMed  Google Scholar 

  • Dubberke ER, Olsen MA (2012) Burden of Clostridium difficile on the healthcare system. Clin Infect Dis 55(Suppl 2):S88–S92. https://doi.org/10.1093/cid/cis335

    Article  PubMed  PubMed Central  Google Scholar 

  • Eckmann C, Wasserman M, Latif F, Roberts G, Beriot-Mathiot A (2013) Increased hospital length of stay attributable to Clostridium difficile infection in patients with four co-morbidities: an analysis of hospital episode statistics in four European countries. Eur J Health Econ 14(5):835–846

    Article  Google Scholar 

  • Freeman J, Bauer MP, Baines SD, Corver J, Fawley WN, Goorhuis B, Kuijper EJ, Wilcox MH (2010) The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev 23(3):529–549. https://doi.org/10.1128/cmr.00082-09

    Article  CAS  Google Scholar 

  • Gabriel L, Beriot-Mathiot A (2014) Hospitalization stay and costs attributable to Clostridium difficile infection: a critical review. J Hosp Infect 88(1):12–21. https://doi.org/10.1016/j.jhin.2014.04.011

    Article  CAS  Google Scholar 

  • Ghantoji SS, Sail K, Lairson DR, DuPont HL, Garey KW (2010) Economic healthcare costs of Clostridium difficile infection: a systematic review. J Hosp Infect 74(4):309–318. https://doi.org/10.1016/j.jhin.2009.10.016

    Article  CAS  Google Scholar 

  • Grube RF, Heinlein W, Scheffer H, Rathmayer M, Schepp W, Lohse AW, Stallmach A, Wilke MH, Lerch MM (2015) Economic burden of Clostridium difficile enterocolitis in German hospitals based on routine DRG data. Z Gastroenterol 53(5):391–397. https://doi.org/10.1055/s-0034-1398803

    Article  CAS  Google Scholar 

  • Hubner C, Hubner NO, Muhr M, Claus F, Leesch H, Kramer A, Flessa S (2015) Cost analysis of hospitalized Clostridium difficile-associated diarrhea (CDAD). GMS Hyg Infect Control 10:Doc13. https://doi.org/10.3205/dgkh000256

  • Jones AM, Kuijper EJ, Wilcox MH (2013) Clostridium difficile: a European perspective. J Inf Secur 66(2):115–128. https://doi.org/10.1016/j.jinf.2012.10.019

    Article  CAS  Google Scholar 

  • Kuijper EJ, Coignard B, Tull P (2006) Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 12(Suppl 6):2–18. https://doi.org/10.1111/j.1469-0691.2006.01580.x

    Article  CAS  Google Scholar 

  • Kulaylat AN, Rocourt DV, Podany AB, Engbrecht BW, Twilley M, Santos MC, Cilley RE, Hollenbeak CS, Dillon PW (2017) Costs of Clostridium difficile infection in pediatric operations: a propensity score-matching analysis. Surgery 161(5):1376–1386. https://doi.org/10.1016/j.surg.2016.10.020

    Article  Google Scholar 

  • Kuntz JL, Johnson ES, Raebel MA, Petrik AF, Yang X, Thorp ML, Spindel SJ, Neil N, Smith DH (2012) Epidemiology and healthcare costs of incident Clostridium difficile infections identified in the outpatient healthcare setting. Infect Control Hosp Epidemiol 33(10):1031–1038. https://doi.org/10.1086/667733

    Article  Google Scholar 

  • Kutty PK, Woods CW, Sena AC, Benoit SR, Naggie S, Frederick J, Evans S, Engel J, McDonald LC (2010) Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Emerg Infect Dis 16(2):197–204. https://doi.org/10.3201/eid1602.090953

    Article  Google Scholar 

  • Le Monnier A, Duburcq A, Zahar JR, Corvec S, Guillard T, Cattoir V, Woerther PL, Fihman V, Lalande V, Jacquier H, Mizrahi A, Farfour E, Morand P, Marcade G, Coulomb S, Torreton E, Fagnani F, Barbut F (2015) Hospital cost of Clostridium difficile infection including the contribution of recurrences in French acute-care hospitals. J Hosp Infect 91(2):117–122. https://doi.org/10.1016/j.jhin.2015.06.017

  • McGlone SM, Bailey RR, Zimmer SM, Popovich MJ, Tian Y, Ufberg P, Muder RR, Lee BY (2012) The economic burden of Clostridium difficile. Clin Microbiol Infect 18(3):282–289. https://doi.org/10.1111/j.1469-0691.2011.03571.x

    Article  CAS  Google Scholar 

  • Mitchell BG, Gardner A (2012) Prolongation of length of stay and Clostridium difficile infection: a review of the methods used to examine length of stay due to healthcare associated infections. Antimicrob Resist Infect Control 1(1):14. https://doi.org/10.1186/2047-2994-1-14

    Article  Google Scholar 

  • Nanwa N, Kendzerska T, Krahn M, Kwong JC, Daneman N, Witteman W, Mittmann N, Cadarette SM, Rosella L, Sander B (2015) The economic impact of Clostridium difficile infection: a systematic review. Am J Gastroenterol 110(4):511–519. https://doi.org/10.1038/ajg.2015.48

    Article  Google Scholar 

  • Nanwa N, Sander B, Krahn M, Daneman N, Lu H, Austin PC, Govindarajan A, Rosella LC, Cadarette SM, Kwong JC (2017) A population-based matched cohort study examining the mortality and costs of patients with community-onset Clostridium difficile infection identified using emergency department visits and hospital admissions. PLoS One 12(3):e0172410. https://doi.org/10.1371/journal.pone.0172410

    Article  Google Scholar 

  • Nasr A, Reichardt K, Fitzgerald K, Arumugusamy M, Keeling P, Walsh TN (2004) Impact of emergency admissions on elective surgical workload. Ir J Med Sci 173(3):133–135

    Article  CAS  Google Scholar 

  • Pillai DR, Longtin J, Low DE (2010) Surveillance data on outbreaks of Clostridium difficile infection in Ontario, Canada, in 2008–2009. Clin Infect Dis 50(12):1685–1686. https://doi.org/10.1086/653007. author reply 1686

    Article  Google Scholar 

  • Poli A, Di Matteo S, Bruno GM, Fornai E, Valentino MC, Colombo GL (2015) Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy. Risk Manag Healthc Policy 8:207–213. https://doi.org/10.2147/rmhp.s90513

  • Robb WB, O’Sullivan MJ, Brannigan AE, Bouchier-Hayes DJ (2004) Are elective surgical operations cancelled due to increasing medical admissions? Ir J Med Sci 173(3):129–132

    Article  CAS  Google Scholar 

  • Ryan P, Skally M, Duffy F, Farrelly M, Gaughan L, Flood P, McFadden E, Fitzpatrick F (2017) Evaluation of fixed and variable hospital costs due to Clostridium difficile infection: institutional incentives and directions for future research. J Hosp Infect 95(4):415–420. https://doi.org/10.1016/j.jhin.2017.01.016

    Article  CAS  Google Scholar 

  • Sammons JS, Localio R, Xiao R, Coffin SE, Zaoutis T (2013) Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children. Clin Infect Dis 57(1):1–8. https://doi.org/10.1093/cid/cit155

  • Singer AJ, Thode HC Jr, Viccellio P, Pines JM (2011) The association between length of emergency department boarding and mortality. Acad Emerg Med 18(12):1324–1329. https://doi.org/10.1111/j.1553-2712.2011.01236.x

    Article  PubMed  Google Scholar 

  • Van Beurden YH, Bomers MK, van der Werff SD, Pompe EA, Spiering S, Vandenbroucke-Grauls CM, Mulder CJ (2017) Cost analysis of an outbreak of Clostridium difficile infection ribotype 027 in a Dutch tertiary care centre. J Hosp Infect 95(4):421–425. https://doi.org/10.1016/j.jhin.2016.12.019

  • Van Kleef E, Green N, Goldenberg SD, Robotham JV, Cookson B, Jit M, Edmunds WJ, Deeny SR (2014) Excess length of stay and mortality due to Clostridium difficile infection: a multi-state modelling approach. J Hosp Infect 88:213–217

    Google Scholar 

  • VerLee KE, Finks JL, Wilkins MJ, Wells EV (2012) Michigan Clostridium difficile hospital discharges: frequency, mortality, and charges, 2002–2008. Public Health Rep 127(1):62–71

    Article  Google Scholar 

  • Vonberg RP, Reichardt C, Behnke M, Schwab F, Zindler S, Gastmeier P (2008a) Costs of nosocomial Clostridium difficile-associated diarrhoea. J Hosp Infect 70(1):15–20. https://doi.org/10.1016/j.jhin.2008.05.004

    Article  Google Scholar 

  • Wiegand PN, Nathwani D, Wilcox MH, Stephens J, Shelbaya A, Haider S (2012) Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection. J Hosp Infect 81(1):1–14. https://doi.org/10.1016/j.jhin.2012.02.004

    Article  CAS  Google Scholar 

  • Wilcox MH, Cunniffe JG, Trundle C, Redpath C (1996) Financial burden of hospital-acquired Clostridium difficile infection. J Hosp Infect 34(1):23–30

    Article  CAS  Google Scholar 

  • Wilcox MH, Ahir H, Coia JE, Dodgson A, Hopkins S, Llewelyn MJ, Settle C, McLain-Smith S, Marcella SW (2017) Impact of recurrent Clostridium difficile infection: hospitalization and patient quality of life. J Antimicrob Chemother 72:2647–2656. https://doi.org/10.1093/jac/dkx174

    Article  Google Scholar 

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Correspondence to Elena Reigadas Ramírez or Emilio Santiago Bouza .

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Reigadas Ramírez, E., Bouza, E.S. (2018). Economic Burden of Clostridium difficile Infection in European Countries. In: Mastrantonio, P., Rupnik, M. (eds) Updates on Clostridium difficile in Europe. Advances in Experimental Medicine and Biology(), vol 1050. Springer, Cham. https://doi.org/10.1007/978-3-319-72799-8_1

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