Abstract
The concept of an aseptic abscesses (AA) syndrome emerged in the late 1980s and early 1990s. Although AA share common features and are sometimes associated with neutrophilic dermatoses (ND), AA syndrome should be considered as a separate entity and not as only extra-cutaneous localizations of ND, mainly because the deep locations are in many cases the sole feature of AA syndrome. AA syndrome is rather a syndrome than a disease, first because an underlying systemic disorder is frequently encountered, second because of its definition based on (a) abscess-like collections in deep organs (b) lack of microbes, bacteria, virus and parasites after an exhaustive search (c) ineffectiveness of antibiotics (d) high sensitivity to corticosteroid therapy.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
André M, Aumaître O, Marcheix JC, Piette JC. Aseptic systemic abscesses preceding diagnosis of Crohn’s disease by three years. Dig Dis Sci. 1995;40:525–7.
Dallot A, Decazes JM, Drouault Y, Rybojad M, Verola O, Morel P, Modai J, Puissant A. Subcorneal pustular dermatosis (Sneddon Wilkinson disease) with amicrobial lymph node suppuration and aseptic spleen abscesses. Br J Dermatol. 1988;119:803–7.
André M, Aumaître O, Marcheix JC, Piette JC. Unexplained sterile systemic abscesses in Crohn’s disease: aseptic abscesses as a new entity. Am J Gastroenterol. 1995;90:1183.
André M, Aumaître O, Papo T, Kemeny JL, Vital-Durand D, Rousset H, Ninet J, Pointud P, Charlotte F, Godeau B, Schmidt J, Marcheix JC, Piette JC. Disseminated aseptic abscesses associated with Crohn’s disease: a new entity? Dig Dis Sci. 1998;43:420–8.
André MF, Piette JC, Kémény JL, Ninet J, Jego P, Delèvaux I, Wechsler B, Weiller PJ, Frances C, Bletry O, Wismans PJ, Rousset H, Colombel JF, Aumaître O, The French Study Group on Aseptic Abscesses. Aseptic abscesses: a study of 30 patients with or without inflammatory bowel disease and review of the literature. Medicine. 2007;86:145–61.
André MF, Aumaître O, Piette JC, Grateau G, Cardoso MC, Ouchchane L, Kémény JL, Dastugue B, Delpech M, Creveaux I. Analysis of the NOD2/CARD15 gene in patients affected with the aseptic abscesses syndrome with or without inflammatory bowel disease. Dig Dis Sci. 2008;53:490–9.
André MFJ, Aumaître O, Grateau G, Chamaillard M, Costedoat-Chalumeau N, Cardoso MC, Henry-Berger J, Ramakrishna BS, Delpech M, Piette J-C, Creveaux I. Longest form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients. Dig Dis Sci. 2010;55:1681–8.
Bardy A, Creveaux I, Déchelotte P, Kémény JL, Rioux-Leclercq N, Aumaître O, André M. Elévation de la transcription d’IL-1β dans les abcès aseptiques. Rev Med Interne. 2010;31:392–3s.
Guettrot-Imbert G, Haroche J, Grimon G, Charlotte F, Ninet J, Possenti S, Kelly A, Amoura Z, Aumaître O, André M. F-18 FDG-PET/CT in aseptic abscesses with recurrent febrile abdominal pain. Scand J Gastroenterol. 2011;46:577–82.
Bardy A, Guettrot-Imbert G, Aumaître O, André M. Efficacy of Il-1β blockade in refractory aseptic abscesses syndrome. Mod Rheumatol. 2014;24:217–9.
Kato S, Hosomi E, Amano F, Kobayashi T, Kani K, Yamamoto R, Ogawa T, Matsuda A, Sato Y, Izaki S, Mitarai T, Yakabi K. The efficacy of intensive granulocyte and monocyte adsorption apheresis in a patient with Crohn’s disease complicated by extensive subcutaneous aseptic neutrophilic abscesses. J Crohns Colitis. 2012;6:787–91.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
André, M. (2018). Aseptic Abscesses Syndrome. In: Wallach, D., Vignon-Pennamen, MD., Valerio Marzano, A. (eds) Neutrophilic Dermatoses. Springer, Cham. https://doi.org/10.1007/978-3-319-72649-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-72649-6_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-72648-9
Online ISBN: 978-3-319-72649-6
eBook Packages: MedicineMedicine (R0)