Abstract
Magnesium (Mg) and its alloys degrade under physiological conditions. But how strong is the connection between the implant, the corrosion layer and the surrounding tissue, namely bone? Biomechanical tests like push-out tests have shown that a degraded Mg-pin is surprisingly well integrated with the bone “as reported by Castellani et al. (Acta Biomater 7(1):432–440, 2011) [1]”. High-resolution synchrotron tomography offers a deep look into the microstructure of the material as well as of the bone during deformation until fracture happens. Here we present first data from an in situ tomography experiment of a biodegradable Mg-based implant under compressive load showing how Mg implants are incorporated into bone.
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References
Castellani C, Lindtner RA, Hausbrandt P, Tschegg E, Stanzl-Tschegg SE, Zanoni G, Beck S, Weinberg A-M (2011) Bone-implant interface strength and osseointegration: biodegradable magnesium alloy versus standard titanium control. Acta Biomater 7(1):432–440
Mittal R, Morley J, Dinopoulos H, Drakoulakis EG, Vermani E, Giannoudis PV (2005) Use of bio-resorbable implants for stabilisation of distal radius fractures: the United Kingdom patients’ perspective. Injury 36(2):333–338
Sanchez AHM, Luthringer BJC, Feyerabend F, Willumeit R (2015) Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates? a review. Acta Biomater 13:16–31
Hoerth RM, Seidt BM, Shah M, Schwarz C, Willie BM, Duda GN, Fratzl P, Wagermaier W (2014) Mechanical and structural properties of bone in non-critical and critical healing in rat. Acta Biomater 10(9):4009–4019
Liu Y, Manjubala I, Roschger P, Epari DR, Schell H, Lienau J, Bail HJ, Duda GN, Fratzl P (2009) The evolution of size and distribution of apatite mineral crystals during bone fracture healing in sheep. Bone 44:S271–S272
Liu Y, Roschger P, Manjubala I (2008) Characteristics of mineral particles in the callus during fracture healing in a sheep model. Calcif Tissue Int 82
Liu Y, Manjubala I, Schell H, Epari DR, Roschger P, Duda GN, Fratzl P (2010) Size and habit of mineral particles in bone and mineralized callus during bone healing in sheep. J Bone Miner Res 25(9):2029–2038
Szmukler-Moncler S, Salama H, Reingewirtz Y, Dubruille JH (1998) Timing of loading and effect of micromotion on bone–dental implant interface: review of experimental literature. J Biomed Mater Res 43(2):192–203
Peng Qiuming, Huang Yuanding, Zhou Le, Hort Norbert, Kainer Karl Ulrich (2010) Preparation and properties of high purity mg–y biomaterials. Biomaterials 31(3):398–403
Haibel A, Beckmann F, Dose T, Herzen J, Ogurreck M, Müller M, Schreyer A (2010) Latest developments in microtomography and nanotomography at PETRA III. Powder Diffr 25(2):161–164
Haibel A, Ogurreck M, Beckmann F, Dose T, Wilde F, Herzen J, Müller M, Schreyer A, Nazmov V, Simon M, Last A, Mohr J (2010) Micro- and nano-tomography at the GKSS imaging beamline at PETRA III. In: Proceedings of SPIE, p 78040B
Wilde F, Ogurreck M, Greving I, Hammel JU, Beckmann F, Hipp A, Lottermoser L, Khokhriakov I, Lytaev P, Dose T, Burmester H, Müller M, Schreyer A (2016) Micro-CT at the imaging beamline P05 at PETRA III. In: AIP conference proceedings, vol 1741(1), p 030035
Wetterlöv Charyeva O (2015) Bioresorbable magnesium implants for bone applications. PhD thesis, Justus-Liebig-Universität
Moosmann J, Zeller-Plumhoff B, Wieland DCF, Galli S, Krüger D, Dose T, Burmester H, Wilde F, Bech M, Peruzzi N, Wiese B, Hipp A, Beckmann F, Hammel JU, Willumeit-Römer R (2017) Biodegradable magnesium-based implants in bone studied by synchrotron radiation microtomography. In: Proceedings of SPIE—developments in x-ray tomography XI, vol 10391–23
Acknowledgements
This research was carried out within the SynchroLoad project (BMBF project number 05K16CGA) and the MgBone project (BMBF project number 05K16CGB) which are funded by the Röntgen-Ångström Cluster (RÅC), a bilateral research collaboration of the Swedish government and the German Federal Ministry of Education and Research (BMBF). We acknowledge provision of beamtime, related to the proposals I-20160658 and I-20160104, at beamline P05 at PETRA III at DESY, a member of the Helmholtz Association (HGF). We would like to thank Thomas Dose, Hilmar Burmester, and Jens Brehling for designing and constructing the load frame. We are also very grateful for the support by Fabian Wilde, Alexander Hipp, and Monika Luczak.
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Willumeit-Römer, R. et al. (2018). Visualization of Implant Failure by Synchrotron Tomography. In: & Materials Society, T. (eds) TMS 2018 147th Annual Meeting & Exhibition Supplemental Proceedings. TMS 2018. The Minerals, Metals & Materials Series. Springer, Cham. https://doi.org/10.1007/978-3-319-72526-0_25
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DOI: https://doi.org/10.1007/978-3-319-72526-0_25
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