A Mathematical Model of Nucleic Acid Thermodynamics

  • Sonia Guarguagli
  • Franco Pastrone
Part of the Advanced Structured Materials book series (STRUCTMAT, volume 89)


The DNA denaturation, the double-stranded DNA unwinding process, is a vital process for cells. The percentage of the denaturation is used as an index of organism complexity and it is the base of the DNA hybridisation technique, which provides a great deal of information. It can be detected by observing the increase in the ability of a DNA solution to absorb ultraviolet light at a wavelength of 260 nm. Based on experimental data, we found a mathematical model capable of predicting the behaviour of a general DNA, given the melting temperature T m .


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Università degli Studi di TorinoTorinoItaly
  2. 2.Accademia delle Scienze di TorinoTorinoItaly

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