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Drug-Food Interactions

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Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions

Part of the book series: Infectious Disease ((ID))

Abstract

Drug–food interactions can be detrimental to the pharmacologic treatment of infectious diseases by decreasing the efficacy or increasing the toxicity of antimicrobials. Compared to well-known drug–drug interactions, drug–food interactions often go unrecognized and can lead to poor clinical outcomes. In addition to affecting the risk–benefit ratio of the antimicrobial, drug–food interactions can be cumbersome to patients and lead to nonadherence due to interference with daily activities. This chapter will discuss the mechanisms of drug–food interaction, the appropriate methodology for food-effect studies, the specific effects of food on a variety of antimicrobials, as well as the recommended dosing guidelines for administration with regard to meals.

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Authors and Affiliations

  1. University of Illinois at Chicago, College of Pharmacy, Chicago, IL, USA

    Eric Wenzler

  2. Achaogen, Inc, San Fransisco, CA, USA

    Kelly Sprandel-Harris

  3. Colleges of Pharmacy and Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Keith A. Rodvold

Authors
  1. Eric Wenzler
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  2. Kelly Sprandel-Harris
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  3. Keith A. Rodvold
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Corresponding author

Correspondence to Keith A. Rodvold .

Editor information

Editors and Affiliations

  1. College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA

    Manjunath P. Pai

  2. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA

    Jennifer J. Kiser

  3. Division of Pharmacy Practice and Administration, UMKC School of Pharmacy at MSU, Springfield, Missouri, USA

    Paul O. Gubbins

  4. College of Pharmacy and Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

    Keith A. Rodvold

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Wenzler, E., Sprandel-Harris, K., Rodvold, K.A. (2018). Drug-Food Interactions. In: Pai, M., Kiser, J., Gubbins, P., Rodvold, K. (eds) Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions. Infectious Disease. Humana Press, Cham. https://doi.org/10.1007/978-3-319-72422-5_4

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  • DOI: https://doi.org/10.1007/978-3-319-72422-5_4

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