Cutaneous Autoimmune Connective Tissue Disorders

Chapter

Abstract

Gender has a significant influence on the development of autoimmune diseases whereby in general, women are more susceptible than men. The established striking predominance in females in most of cutaneous collagen disorders such as Systemic Lupus Erythematosus, Systemic Sclerosis or Siogren Syndrome is related mainly to the complex interactions of sex hormones and the immune system.

Despite the increased awareness and significant progress in research detailed in this review, there is still a gap of reference to gender in some skin specific autoimmune disorders investigated, providing challenging future goals.

Keywords

Female predominance Gender dimorphism Immunologic hormonal interface Multifactorial pathogenesis Environmental and lifestyle induced autoimmunity 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Maccabi Health ServicesTel AvivIsrael
  2. 2.Ben Gurion University of the NegevBeer ShevaIsrael

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