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Paracoccidioidomycosis ceti (Lacaziosis/Lobomycosis) in Dolphins

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Emerging and Epizootic Fungal Infections in Animals

Abstract

Infections caused by the fungal pathogen Lacazia loboi were first reported in 1931 by Jorge de Oliveira Lobo in a human with granulomatous skin lesions in Pernambuco, Brazil. Early histopathological and serological analyses found morphological similarities and cross-reactive antigens with Paracoccidioides brasiliensis. In 1971, veterinarians working with dolphins in Florida, USA, reported granulomatous skin lesions in a dolphin, similar to that in human lacaziosis. Based on histopathological findings, L. loboi was initially believed to be also the etiologic agent of cutaneous disease in dolphins. Ever since, cutaneous granulomas have been reported in different dolphin species around the coast of Asia, Europe, and North and South America. Recently, using molecular biology approaches, some investigators stated that the DNA sequences extracted from cases of cutaneous granulomas in dolphins were closely related to those of P. brasiliensis. This chapter deals with the history, taxonomy, and other features of L. loboi in humans and the unculturable P. brasiliensis var. ceti type affecting the skin of dolphins.

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Authors and Affiliations

  1. Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Raquel Vilela

  2. Biomedical Laboratory Diagnostics, Michigan State University, East Lansing, MI, USA

    Raquel Vilela

  3. Microbiology and Molecular Genetics, Biomedical Laboratory Diagnostics, Michigan State University, East Lansing, MI, USA

    Leonel Mendoza

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  1. Raquel Vilela
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Correspondence to Leonel Mendoza .

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Editors and Affiliations

  1. Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA

    Seyedmojtaba Seyedmousavi

  2. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

    G. Sybren de Hoog

  3. Department of Parasitology, Mycology and Dermatology, EnvA, Ecole nationale vétérinaire d’Alfort, UPEC, Maisons-Alfort, France

    Jacques Guillot

  4. Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands

    Paul E. Verweij

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Vilela, R., Mendoza, L. (2018). Paracoccidioidomycosis ceti (Lacaziosis/Lobomycosis) in Dolphins. In: Seyedmousavi, S., de Hoog, G., Guillot, J., Verweij, P. (eds) Emerging and Epizootic Fungal Infections in Animals. Springer, Cham. https://doi.org/10.1007/978-3-319-72093-7_9

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