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Filamentous Phage: Structure and Biology

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Recombinant Antibodies for Infectious Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1053))

Abstract

Ff filamentous phage (fd, M13 and f1) of Escherichia coli have been the workhorse of phage display technology for the past 30 years. Dominance of Ff over other bacteriophage in display technology stems from the titres that are about 100-fold higher than any other known phage, efficacious transformation ensuring large library size and superior stability of the virion at high temperatures, detergents and pH extremes, allowing broad range of biopanning conditions in screening phage display libraries. Due to the excellent understanding of infection and assembly requirements, Ff phage have also been at the core of phage-assisted continual protein evolution strategies (PACE). This chapter will give an overview of the Ff filamentous phage structure and biology, emphasizing those properties of the Ff phage life cycle and virion that are pertinent to phage display applications.

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Acknowledgments

Jasna Rakonjac wishes to especially acknowledge the late Peter Model (Rockefeller University), for generously sharing his knowledge through discussions and advice, and for the gifts of filamentous phage and E. coli strain collections. Funding to JR laboratory by Palmerston North Medical Research Foundation, Massey University, Institute of Fundamental Sciences, Anonymous Donor and the Maurice Wilkins Centre for Molecular Biodiscovery is gratefully acknowledged.

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Authors and Affiliations

  1. Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand

    Jasna Rakonjac, Sofia Khanum, Sam J. Brooke & Marina Rajič

  2. Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand

    Jasna Rakonjac & Marina Rajič

  3. The Rockefeller University, New York, NY, USA

    Marjorie Russel

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  1. Jasna Rakonjac
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  2. Marjorie Russel
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Correspondence to Jasna Rakonjac .

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  1. Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia

    Theam Soon Lim

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This article is dedicated to the memory of Peter Model, a pioneer of filamentous bacteriophage research and a greatly admired mentor to students and junior faculty at the Rockefeller University.

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Rakonjac, J., Russel, M., Khanum, S., Brooke, S.J., Rajič, M. (2017). Filamentous Phage: Structure and Biology. In: Lim, T. (eds) Recombinant Antibodies for Infectious Diseases. Advances in Experimental Medicine and Biology, vol 1053. Springer, Cham. https://doi.org/10.1007/978-3-319-72077-7_1

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