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Amorphous Drug Solubility and Absorption Enhancement

  • Marzena Rams-Baron
  • Renata Jachowicz
  • Elena Boldyreva
  • Deliang Zhou
  • Witold Jamroz
  • Marian Paluch
Chapter

Abstract

The poor oral bioavailability of many active pharmaceutical ingredients (APIs) resulting from low solubility is one of the important challenges in pharmaceutical technology. Over the last two decades the number of relatively insoluble drugs has grown steadily. Nowadays it is estimated that approximately 70% of new drug candidates are characterized by poor solubility. In order to ensure the optimum therapeutic efficacy, the selection of the drug substance and formulation is crucial in drug design. The development and approval of new, innovative and safe drugs is tremendously complex and requires extensive knowledge of materials, current technological processes and regulations. Bearing in mind that the form of drug should be suitable for the administration route and safe to apply, understanding of manufacturing process is of key importance to successful dosage form development.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Marzena Rams-Baron
    • 1
  • Renata Jachowicz
    • 2
  • Elena Boldyreva
    • 3
  • Deliang Zhou
    • 4
  • Witold Jamroz
    • 2
  • Marian Paluch
    • 1
  1. 1.Institute of PhysicsUniversity of SilesiaChorzówPoland
  2. 2.Chair of Pharmaceutical Technology and Biopharmaceutics, Faculty of PharmacyJagiellonian University - Medical CollegeKrakówPoland
  3. 3.Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of SciencesNovosibirsk State UniversityNovosibirskRussian Federation
  4. 4.AbbVieNorth ChicagoUSA

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