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Why Amorphous Drugs?

  • Marzena Rams-Baron
  • Renata Jachowicz
  • Elena Boldyreva
  • Deliang Zhou
  • Witold Jamroz
  • Marian Paluch
Chapter

Abstract

Low aqueous solubility of active pharmaceutical ingredients (APIs) is one of the most important challenges facing drug development researchers today [1, 2]. With the development of computational chemistry and high throughput screening methods it is possible to obtain a large number of compounds with attractive therapeutic activity. However, at the same time the selection of novel active molecules with suitable biopharmaceutical properties (like solubility, intestinal permeability) becomes a great challenge and a bottleneck in drug development. Statistically, more than 40% of approved drugs and even 70–90% of those under investigations are poorly water-soluble and additional efforts are required to improve their water solubility [3–5].

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Marzena Rams-Baron
    • 1
  • Renata Jachowicz
    • 2
  • Elena Boldyreva
    • 3
  • Deliang Zhou
    • 4
  • Witold Jamroz
    • 2
  • Marian Paluch
    • 1
  1. 1.Institute of PhysicsUniversity of SilesiaChorzówPoland
  2. 2.Chair of Pharmaceutical Technology and Biopharmaceutics, Faculty of PharmacyJagiellonian University - Medical CollegeKrakówPoland
  3. 3.Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of SciencesNovosibirsk State UniversityNovosibirskRussian Federation
  4. 4.AbbVieNorth ChicagoUSA

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