Skip to main content

Glycemic Control in Critically Ill Surgical Patients

  • Chapter
  • First Online:
Surgical Critical Care Therapy

Abstract

Alterations in glucose production, distribution, and utilization are frequently observed in critical illness. Whether these alterations are a cause or consequence of illness, beneficial or detrimental to recovery, remains to be fully understood. It will be the focus of this chapter to provide an evidence-based, formulaic approach to insulin therapy that proactively incorporates each patient’s baseline state of health as well the expected evolution of their acute disease process and therapeutic needs. The chapter will provide methods for the reactive, fine-tuning of blood glucose management that utilizes information derived from the early stages of glucose control while transitioning to more reliable, less labor-intensive insulin regimens. Lastly, it will provide a method for dealing with the complications of glycemic control that result in dangerous levels of hyper- and hypoglycemia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Badawi O, Waite MD, Fuhrman SA, Zuckerman IH. Association between intensive care unit-acquired dysglycemia and in-hospital mortality. Crit Care Med. 2012;40(12):3180–8. https://doi.org/10.1097/CCM.0b013e3182656ae5.

    Article  PubMed  Google Scholar 

  2. Jacobi J, Bircher N, Krinsley J, Agus M, Braithwaite SS, Deutschman C, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012;40(12):3251–76. https://doi.org/10.1097/CCM.0b013e3182653269.

    Article  Google Scholar 

  3. van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345(19):1359–67. https://doi.org/10.1056/NEJMoa011300.

    Article  Google Scholar 

  4. American Diabetes Association. Standards of medical care in diabetes--2008. Diabetes Care. 2008;31(Suppl 1):S12–54. https://doi.org/10.2337/dc08-S012.

    Article  CAS  Google Scholar 

  5. Investigators N-SS, Finfer S, Chittock DR, Su SY, Blair D, Foster D, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–97. https://doi.org/10.1056/NEJMoa0810625.

    Article  Google Scholar 

  6. Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet. 2009;373(9677):1798–807. https://doi.org/10.1016/S0140-6736(09)60553-5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Marik PE, Bellomo R. Stress hyperglycemia: an essential survival response! Crit Care Med. 2013;41(6):e93–4. https://doi.org/10.1097/CCM.0b013e318283d124.

    Article  PubMed  Google Scholar 

  8. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449–61. https://doi.org/10.1056/NEJMoa052521.

    Article  PubMed  Google Scholar 

  9. Griesdale DE, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, et al. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ. 2009;180(8):821–7. https://doi.org/10.1503/cmaj.090206.

    Article  PubMed  Google Scholar 

  10. Furnary AP, Gao G, Grunkemeier GL, Wu Y, Zerr KJ, Bookin SO, et al. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003;125(5):1007–21. https://doi.org/10.1067/mtc.2003.181.

    Article  CAS  PubMed  Google Scholar 

  11. Ouattara A, Lecomte P, Le Manach Y, Landi M, Jacqueminet S, Platonov I, et al. Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients. Anesthesiology. 2005;103(4):687–94.

    Article  CAS  Google Scholar 

  12. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010;137(3):544–51. https://doi.org/10.1378/chest.09-1737.

    Article  CAS  PubMed  Google Scholar 

  13. Hoedemaekers CW, Klein Gunnewiek JM, Prinsen MA, Willems JL, Van der Hoeven JG. Accuracy of bedside glucose measurement from three glucometers in critically ill patients. Crit Care Med. 2008;36(11):3062–6. https://doi.org/10.1097/CCM.0b013e318186ffe6.

    Article  CAS  PubMed  Google Scholar 

  14. Food and Drug Aministration U.S. Department of health and human services, blood glucose monitoring test systems for presciption point-of-care use, Guidance for Industry and Food and Drug Administration Staff. Rockville; 2016.

    Google Scholar 

  15. Food and Drug Administration. FDA clears glucose monitoring system for use in hospital critical care units. 2014. https://wayback.archive-it.org/7993/2016022101309/fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm416144.htm . Accessed 04 Nov 2017.

  16. Breuker C, Abraham O, di Trapanie L, Mura T, Macioce V, Boegner C, Jalabert A, Villiet M, Castet-Nicolas A, Avignon A, Sultan A. Patients with diabetes are at high risk of serious medication errors at hospital: interest of clinical pharmacist intervention to improve healthcare. Eur J Intern Med. 2016. doi:https://doi.org/10.1016/j.ejim.2016.12.003.

    Article  PubMed  Google Scholar 

  17. (ISMP). IfSMP (Accessed January 13, 2017.) ISMP list of high-alert medications in acute care settings. Available at http://www.ismporg/Tools/highalertmedicationspdf.

  18. Clement S, Braithwaite SS, Magee MF, Ahmann A, Smith EP, Schafer RG, et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care. 2004;27(2):553–91.

    Article  Google Scholar 

  19. Bodmer M, Meier C, Krahenbuhl S, Jick SS, Meier CR. Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. Diabetes Care. 2008;31(11):2086–91. https://doi.org/10.2337/dc08-1171.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Salpeter SR, Greyber E, Pasternak GA, Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev. 2010;4:CD002967. https://doi.org/10.1002/14651858.CD002967.pub4.

    Article  Google Scholar 

  21. Eppenga WL, Lalmohamed A, Geerts AF, Derijks HJ, Wensing M, Egberts A, et al. Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. Diabetes Care. 2014;37(8):2218–24. https://doi.org/10.2337/dc13-3023.

    Article  CAS  PubMed  Google Scholar 

  22. Firestone RL, Pandya PK, Parker PL, Duby JJ. Effect of a conservative correction DKA protocol on clinical outcomes in hospitalized patients. Crit Care Med. 2013;41(12):A16.

    Article  Google Scholar 

  23. Krinsley JS. Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med. 2008;36(11):3008–13. https://doi.org/10.1097/CCM.0b013e31818b38d2.

    Article  CAS  PubMed  Google Scholar 

  24. Murthy MS, Duby JJ, Parker PL, Durbin-Johnson BP, Roach DM, Louie EL. Blood glucose response to rescue dextrose in hypoglycemic, critically ill patients receiving an insulin infusion. Ann Pharmacother. 2015;49(8):892–6. https://doi.org/10.1177/1060028015585574.

    Article  CAS  PubMed  Google Scholar 

  25. Plummer MP, Bellomo R, Cousins CE, Annink CE, Sundararajan K, Reddi BA, et al. Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality. Intensive Care Med. 2014;40(7):973–80. https://doi.org/10.1007/s00134-014-3287-7.

    Article  CAS  PubMed  Google Scholar 

  26. Marik PE, Egi M. Treatment thresholds for hyperglycemia in critically ill patients with and without diabetes. Intensive Care Med. 2014;40(7):1049–51. https://doi.org/10.1007/s00134-014-3344-2.

    Article  PubMed  Google Scholar 

  27. Krinsley JS, Schultz MJ, Spronk PE, Harmsen RE, van Braam Houckgeest F, van der Sluijs JP, et al. Mild hypoglycemia is independently associated with increased mortality in the critically ill. Crit Care. 2011;15(4):R173. https://doi.org/10.1186/cc10322.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Nathan DM, Kuenen J, Borg R, Zheng H, Schoenfeld D, Heine RJ, et al. Translating the A1C assay into estimated average glucose values. Diabetes Care. 2008;31(8):1473–8. https://doi.org/10.2337/dc08-0545.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christine S. Cocanour .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Beldowicz, B.C., Duby, J.J., Pigneri, D., Cocanour, C.S. (2018). Glycemic Control in Critically Ill Surgical Patients. In: Salim, A., Brown, C., Inaba, K., Martin, M. (eds) Surgical Critical Care Therapy . Springer, Cham. https://doi.org/10.1007/978-3-319-71712-8_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-71712-8_44

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-71711-1

  • Online ISBN: 978-3-319-71712-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics