Skip to main content
SpringerLink
Log in
Book cover

The Interventional Cardiology Training Manual pp 263–274Cite as

Percutaneous Coronary Intervention for Left Ventricular Systolic Dysfunction

  • Chapter
  • First Online:

  • 1339 Accesses

Abstract

Heart failure (HF) is a clinical syndrome with symptoms and signs caused by cardiac dysfunction. Its prevalence is estimated at 1–2% in the developed world with an incidence approaching 5–10 per 1000 persons per year. Ischemic heart disease (IHD) is the most common cause of heart failure in the developed world. Heart failure due to ischaemia is associated with worse mortality compared with a non-ischaemic cause. The term ischaemic cardiomyopathy (ICM) has been commonly used to describe impaired left ventricular systolic dysfunction (LVSD: ejection fraction ≤35–40%) resulting from coronary artery disease (CAD). This chapter focuses on the diagnosis and management of ischemic cardiomyopathy. We explore the current evidence base to aid clinical decision-making for invasive versus conservative management. Conventional pharmacological therapy for heart failure will not be discussed in detail in this chapter.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Freeman Hospital Services. [cited 2016 23 September]. http://www.newcastle-hospitals.org.uk/hospitals/freeman-hospital.aspx.

  2. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–200.

    Article  Google Scholar 

  3. Mostered A, Hoes AW. Clinical epidemiology of heart failure. Heart. 2007;93:1137–46.

    Article  Google Scholar 

  4. Felker GM, Shaw LK, O’Connor CM. A standardized definition of ischemic cardiomyopathy for use in clinical research. J Am Coll Cardiol. 2002;39:210–8.

    Article  Google Scholar 

  5. Briceno N, Schuster A, Lumley M, Perera D. Ischaemic cardiomyopathy: pathophysiology, assessment and the role of revascularisation. Heart. 2016;102(5):397–406.

    Article  CAS  Google Scholar 

  6. Writing Committee Memebrs, Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128(16):e240–327.

    Google Scholar 

  7. Yao SS, Chaudhry FA. Assessment of myocardial viability with dobutamine stress echocardiography in patients with ischaemic left ventricular dysfunction. Echocardiography. 2005;22:71–83.

    Article  Google Scholar 

  8. Underwood SR, Bax JJ, Vom Dahl J, et al. Imaging techniques for the assessment of myocardial hibernation: report of a study group of the European society of Cardiology. Eur Heart J. 2004;25:815–36.

    Article  Google Scholar 

  9. Auerbach MA, Schöder H, Hoh C, et al. Prevalence of myocardial viability as detected by positron emission tomography in patients with ischaemic cardiomopathy. Circulation. 1999;99:2921–6.

    Article  CAS  Google Scholar 

  10. Nagel E, Schuster A. Myocardial viability: dead or alive is not the question! JACC Cardiovasc Imaging. 2012;5:509–12.

    Article  Google Scholar 

  11. Allman KC, Shaw LJ, Hachamovitch R, Udelson JE. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol. 2002;39(7):1151–8.

    Article  Google Scholar 

  12. Bourque JM, Hasselblad V, Velazquez EJ, Borges-Neto S, O’Connor CM. Revascularization in patients with coronary artery disease, left ventricular dysfunction, and viability: a meta-analysis. Am Heart J. 2003;146:621–7.

    Article  Google Scholar 

  13. Bonow RO, Maurer G, Lee KL, et al. STICH Trial Investigators. Myocardial viability and survival in ischaemic left ventricular dysfunction. N Engl J Med. 2011;364:1617–25.

    Article  CAS  Google Scholar 

  14. Velazquez EJ, Lee KL, O’Connor CM, Oh JK, Bonow RO, Pohost GM, et al. The rationale and design of the surgical treatment for IsChemic heart failure (STICH) trial. J Thorac Cardiovasc Surg. 2007;134(6):1540–7.

    Article  Google Scholar 

  15. Velazquez EJ, Lee KL, Deja MA, et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med. 2011;364:1607–16.

    Article  CAS  Google Scholar 

  16. Carson P, Wertheimer J, Miller A, et al. The STICH trial mode-of-death results. JACC Heart Fail. 2013;1(5):400–8.

    Article  Google Scholar 

  17. Velazquez EJ, Lee KL, Jones RH, et al. Coronary-artery bypass surgery in patients with ischemic cardiomyopathy. N Engl J Med. 2016;374(16):1511–20.

    Article  CAS  Google Scholar 

  18. Authors/Task Force Members, Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2014;35(37):2541–619.

    Article  Google Scholar 

  19. Hillis LD, Smith PK, Anderson JL, Bittl JA, Bridges CR, Byrne JG, et al. 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124(23):e652–735.

    PubMed  Google Scholar 

  20. Kunadian V, Zaman A, Qiu W. Revascularization among patients with severe left ventricular dysfunction: a meta-analysis of observational studies. Eur J Heart Fail. 2011;13(7):773–84.

    Article  Google Scholar 

  21. Mohr FW, Morice M-C, Kappetein AP, Feldman TE, Ståhle E, Colombo A, et al. Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial. Lancet. 2013;381(9867):629–38.

    Article  Google Scholar 

  22. Davierwala P, Mohr FW. Five years after the SYNTAX trial: what have we learnt? Eur J Cardiothorac Surg. 2013;44(1):1–3.

    Article  Google Scholar 

  23. Kunadian V, Pugh A, Zaman A, Qiu W. Percutaneous coronary intervention among patients with left ventricular systolic dysfunction: a review and meta-analysis of 19 clinical studies. Coron Artery Dis. 2012;23(7):469–79.

    Article  Google Scholar 

  24. Cleland JG, Calvert M, Freemantle N, Arrow Y, Ball SG, Bonser RS, et al. The Heart Failure Revascularisation Trial (HEART). Eur J Heart Fail. 2011;13(2):227–33.

    Article  Google Scholar 

  25. Perera D, Stables R, Thomas M, et al. Elective intra-aortic balloon counterpulsation during high-risk percutaneous coronary intervention: a randomized controlled trial. JAMA. 2010;304(8):867–74.

    Article  CAS  Google Scholar 

  26. Perera D, Stables R, Clayton T, De Silva K, Lumley M, Clack L, et al. Long-term mortality data from the balloon pump-assisted coronary intervention study (BCIS-1): a randomized, controlled trial of elective balloon counterpulsation during high-risk percutaneous coronary intervention. Circulation. 2013;127(2):207–12.

    Article  Google Scholar 

  27. REVIVED-BCIS-2 trial protocol [cited 2016 23 September]. NCT01920048. http://revived.lshtm.ac.uk.

  28. Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement From the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006;113(14):1807–16.

    Article  Google Scholar 

  29. Parodi G, Del Pace S, Carrabba N, Salvadori C, Memisha G, Simonetti I, et al. Incidence, clinical findings, and outcome of women with left ventricular apical ballooning syndrome. Am J Cardiol. 2007;99(2):182–5.

    Article  Google Scholar 

  30. Kurisu S, Sato H, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, et al. Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J. 2002;143(3):448–55.

    Article  Google Scholar 

  31. Tsuchihashi K, Ueshima K, Uchida T, Oh-mura N, Kimura K, Owa M, et al. Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. J Am Coll Cardiol. 2001;38(1):11–8.

    Article  CAS  Google Scholar 

  32. Azzarelli S, Galassi AR, Amico F, Giacoppo M, Argentino V, Tomasello SD, et al. Clinical features of transient left ventricular apical ballooning. Am J Cardiol. 2006;98(9):1273–6.

    Article  Google Scholar 

  33. Haghi D, Fluechter S, Suselbeck T, Kaden JJ, Borggrefe M, Papavassiliu T. Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy). Int J Cardiol. 2007;120(2):205–11.

    Article  Google Scholar 

  34. Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J. 2008;155(3):408–17.

    Article  Google Scholar 

  35. Elesber AA, Prasad A, Lennon RJ, Wright RS, Lerman A, Rihal CS. Four-year recurrence rate and prognosis of the apical ballooning syndrome. J Am Coll Cardiol. 2007;50(5):448–52.

    Article  Google Scholar 

  36. Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, et al. Presentation of Tako-tsubo cardiomyopathy in men and women. Clin Cardiol. 2010;33(1):42–5.

    Article  Google Scholar 

  37. Bybee KA, Kara T, Prasad A, Lerman A, Barsness GW, Wright RS, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 2004;141(11):858–65.

    Article  Google Scholar 

  38. Ghadri J-R, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Shams Y-H, Migliore F, Horowitz JD, Shimokawa H, Lüscher TF, Templin C. International expert consensus document on Takotsubo Syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology. European Heart Journal. 2018;39(22):2032–46. https://doi.org/10.1093/eurheartj/ehy076.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

    Sophie Zhaotao Gu, Hani Ali, Azfar Zaman & Vijay Kunadian

  2. Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK

    Sophie Zhaotao Gu, Hani Ali, Azfar Zaman & Vijay Kunadian

  3. Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK

    Amr Gamal, Christopher Eggett & Richard Edwards

Authors
  1. Sophie Zhaotao Gu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amr Gamal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christopher Eggett
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hani Ali
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Azfar Zaman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Richard Edwards
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Vijay Kunadian
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vijay Kunadian .

Editor information

Editors and Affiliations

  1. Brighton and Sussex Medical School and the Sussex Cardiac Centre, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK

    Aung Myat

  2. Royal Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, UK

    Sarah Clarke

  3. Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK

    Nick Curzen

  4. Department of Cardiology, Bern University Hospital, Bern, Switzerland

    Stephan Windecker

  5. Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, VA, USA

    Paul A. Gurbel

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gu, S.Z. et al. (2018). Percutaneous Coronary Intervention for Left Ventricular Systolic Dysfunction. In: Myat, A., Clarke, S., Curzen, N., Windecker, S., Gurbel, P.A. (eds) The Interventional Cardiology Training Manual. Springer, Cham. https://doi.org/10.1007/978-3-319-71635-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-71635-0_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-71633-6

  • Online ISBN: 978-3-319-71635-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation