Abstract
The nuclear pore complex (NPC) serves as gateway for transport between the cytoplasm and the nucleus and its structure as well as individual components (nucleoporins or nups) are conserved among all eukaryotes, suggesting they evolved in an ancient common ancestor. In addition to their role in nucleocytoplasmic transport, nups located either at NPCs or in the nucleoplasm participate in regulation of gene expression, DNA repair and chromosome segregation during cell division. Far from being a static structure, recent studies have demonstrated that alterations in NPC composition or function occur as consequences of normal cell differentiation, physiological aging and disease. In this review, we discuss how the popular model organism Caenorhabditis elegans has contributed to our understanding of NPC biogenesis and function from single cell resolution in young embryos to organismal homeostasis in adults.
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Acknowledgments
Our laboratory is supported by the Spanish Ministry of Economy and Competitiveness (BFU2013-42709-P, BFU2016-79313-P and BES-2014-068609), the European COST Program (BM1408 GENiE) and the European Regional Development Fund. We are grateful to Thomas Schwartz for help with prediction of “missing” C. elegans nups and to Agnieszka Dobrzynska for critical reading of the manuscript.
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Muñoz-Jiménez, C.M., Askjaer, P. (2018). Caenorhabditis elegans Nuclear Pore Complexes in Genome Organization and Gene Expression. In: D’Angelo, M. (eds) Nuclear Pore Complexes in Genome Organization, Function and Maintenance. Springer, Cham. https://doi.org/10.1007/978-3-319-71614-5_6
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