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Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs pp 129–139Cite as

The Roles of miR-25 and Its Targeted Genes in Human Cancer

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Abstract

Since of their discovery in mammalians, microRNAs (miRNAs) have been associated to almost every physiological function within cells, tissues and organs. miRNAs are small non-coding RNAs that regulate gene expression by targeting messenger RNAs for translational repression or, at lesser extent, mRNAs degradation. Within the several functions controlled by miRNAs there are the control of cell proliferation, apoptosis, differentiation, cell migration, autophagy and metabolism. Thus, the uncontrolled expression of miRNAs has been associated with cancer onset, progression and cancer spreading into metastasis. miRNAs up- or down-regulation has been linked to oncogenic and tumor-suppressive roles in all type of cancers. Altered expression of many miRNAs has been reported many human malignant tumors, participating in various cellular processes accordingly with its broad range of potential mRNAs target. Here, we want to briefly discuss the mechanisms underlying miRNA-mediated tumorigenesis in different human cancers, presenting, as an example, the oncogenic and tumor-suppressive function of miR-25. Moreover, we summarize the possible future as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications and the main techniques to study miRNAs.

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Authors and Affiliations

  1. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Napoli, Italy

    Carmen Caiazza & Massimo Mallardo

  2. CNR-ISPA, Institute of Sciences of Food Productions, National Research Council, Lecce, Italy

    Palmiro Poltronieri

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  1. Carmen Caiazza
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  2. Palmiro Poltronieri
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Editors and Affiliations

  1. Department of Biochemistry, Rashid Latif Medical College (RLMC), Lahore, Pakistan

    Sundas Fayyaz

  2. Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

    Ammad Ahmad Farooqi

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Caiazza, C., Poltronieri, P., Mallardo, M. (2018). The Roles of miR-25 and Its Targeted Genes in Human Cancer. In: Fayyaz, S., Farooqi, A. (eds) Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Springer, Cham. https://doi.org/10.1007/978-3-319-71553-7_7

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