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Tranquilizing and Awakening ATM to Promote Killing of Cancer Cells

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Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs

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Abstract

Maintenance of genomic integrity is a major challenge, as DNA is exposed to incessantly ongoing nucleolytic attacks from both exogenous and endogenous sources. To overcome these stumbling blocks, cells have evolved a global DNA damage response (DDR), which is an intricate and hierarchically organized network of interweaved pathways that are “switched on” whenever genotoxic insults occurs. ATM, ATR, and DNA-PK are multitalented modulators of DNA damage signaling which play a significant role in synchronizing and orchestrating an array of proteins at the site of DNA damage. Overwhelmingly, genomic and proteomic data have helped us to map the landscape of ATM mediated regulation of myriad of proteins in normal and cancer cells. Complex information has shown to “diametrically opposed” roles of ATM kinase in different cancers. Scientists have investigated effects of ATM activation and inhibition in different cancers and it is now clear that context-dependent activation or inhibition can consequently improve apoptotic rate of cancer cells. In this chapter we will summarize the most recent advancements of ATM kinase in different cancers and critically evaluated the effects of ATM activation or inhibition on apoptosis and drug resistance of cancer cells.

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Author information

Authors and Affiliations

  1. Translational Brain Cancer Research, QIMR Berghofer Medical Research Institute, Brisbane City, QLD, Australia

    Yi Chieh Lim

  2. Department of Human Genetics, University of Health Sciences, Lahore, Pakistan

    Shahzad Bhatti

  3. Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

    Ammad Ahmad Farooqi

Authors
  1. Yi Chieh Lim
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  2. Shahzad Bhatti
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  3. Ammad Ahmad Farooqi
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Corresponding author

Correspondence to Shahzad Bhatti .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, Rashid Latif Medical College (RLMC), Lahore, Pakistan

    Sundas Fayyaz

  2. Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

    Ammad Ahmad Farooqi

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Lim, Y.C., Bhatti, S., Farooqi, A.A. (2018). Tranquilizing and Awakening ATM to Promote Killing of Cancer Cells. In: Fayyaz, S., Farooqi, A. (eds) Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Springer, Cham. https://doi.org/10.1007/978-3-319-71553-7_4

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