Interpretation of Results from Tables, Graphs, and Regressions in Cancer Research
Tables and graphs are often used in clinical research articles. This chapter especially considers these items and addresses the way to create Tables and the ways to interpret graphs and curves in oncologic clinical research. Tables must present complete and clear access to data, and Figures should work as an enabler resource to better reveal interesting points in the article. The main tools used to identify associations between exposure and outcomes in clinical research are univariate regression and multivariate regression; here we describe the use of these methods. However, despite being widely used in cancer research, these tools are not easily interpreted, are sometimes overused, and may be associated with hidden biases.
KeywordsOutcomes Regressions Survival analyses Data distribution Cancer Multivariate analysis
- 3.Langer B, Bleiberg H, Labianca R, Shepherd L, Nitti D, Marsoni S, et al. Fluorouracil (FU) Plus L-leucovorin (L-LV) versus observation after potentially curative resection of liver or lung metastases from colorectal cancer (CRC): results of the ENG (EORTC/NCIC CTG/GIVIO) randomized trial. Proc Am Soc Clin Oncol. 2002;21:149a. Abstract 592.Google Scholar
- 5.Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371:1007–16.CrossRefGoogle Scholar
- 6.Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative FOLFOX4 chemotherapy and sur gery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14:1208–15.CrossRefGoogle Scholar
- 9.Ihemelandu C, Levine EA, Aklilu M, Yacoub G, Howerton R, Bolemon B, et al. Optimal timing of systemic therapy in resect able colorectal liver metastases. Am Surg. 2013;79:422–8.Google Scholar