Abstract
The diagnostic category “neoplasm” is a true reflection of what is encountered in the daily practice of salivary gland fine-needle aspiration (FNA). It is divided into two subcategories: (1) benign neoplasm and (2) salivary gland neoplasm of uncertain malignant potential (SUMP). The former category includes common benign neoplasms that are diagnosed with high specificity such as pleomorphic adenoma and Warthin tumor, whereas the latter includes tumors where a specific diagnosis and differentiation between a benign and usually low-grade malignant neoplasm is not possible due to inherent cytomorphologic features or to limited cytologic material. FNA cases diagnosed as SUMP will mandate a differential diagnosis that includes both benign and malignant entities. In The Milan System for Reporting Salivary Gland Cytopathology, the risk of malignancy (based on review of the literature) for the benign neoplasm and SUMP categories is <5% and 35%, respectively.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Klijanienko J, Vielh P. Fine-needle sampling of salivary gland lesions. II. Cytology and histology correlation of 71 cases of Warthin’s tumor (adenolymphoma). Diagn Cytopathol. 1997;16(3):221–5.
Colella G, Cannavale R, Flamminio F, Foschini MP. Fine-needle aspiration cytology of salivary gland lesions: a systematic review. J Oral Maxillofac Surg. 2010;68(9):2146–53.
Faquin WC, Powers CN. Salivary gland cytopathology. Essentials in cytopathology, vol. 5. Rosenthal DL, series editor. New York: Springer; 2008.
Eneroth CM, Jakobsson P, Zajicek J. Aspiration biopsy of salivary gland tumors. V. Morphologic investigations on smears and histologic sections of acinic cell carcinoma. Acta Radiol Suppl. 1971;310:85–93.
Griffith CC, Pai RK, Schneider F, Duvvuri U, Ferris RL, Johnson JT, Seethala RR. Salivary gland tumor fine-needle aspiration cytology: a proposal for a risk stratification classification. Am J Clin Pathol. 2015;143(6):839–53.
Ashraf A, Shaikh AS, Kamal F, Sarfraz R, Bukhari MH. Diagnostic reliability of FNAC for salivary gland swellings: a comparative study. Diagn Cytopathol. 2010;38(7):499–504.
Zerpa VZ, Gonzáles MTC, Porras GA, Acuña MM, Ferriol EE, Galofre JD. Diagnostic accuracy of fine needle aspiration cytology in parotid tumours. Acta Otorrinolaringol. 2014;65(3):157–61.
Rossi ED, Wong LQ, Bizzarro T, Petrone G, Mule A, Fadda G, Baloch ZM. The impact of FNAC in the management of salivary gland lesions: institutional experiences leading to a risk-based classification scheme. Cancer Cytopathol. 2016;124(6):388–96.
Brandwein MS, Huvos AG. Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. Am J Surg Pathol. 1991;15(6):514–28.
Walaas L, Kindblom LG. Lipomatous tumors: a correlative cytologic and histologic study of 27 tumors examined by fine needle aspiration cytology. Hum Pathol. 1985;16(1):6–18.
Eneroth CM. Histological and clinical aspects of parotid tumours. Acta Otolaryngol Suppl. 1964;188(Suppl 191):1–99.
Mooney EE, Layfield LJ, Dodd LG. Fine-needle aspiration of neural lesions. Diagn Cytopathol. 1999;20(1):1–5.
Childers EL, Furlong MA, Fanburg-Smith JC. Hemangioma of the salivary gland: a study of ten cases of a rarely biopsied/excised lesion. Ann Diagn Pathol. 2002;6(6):339–44.
Klijanienko J, Vielh P. Fine-needle sample of salivary gland lesions. V: cytology of 22 cases of acinic cell carcinoma with histologic correlation. Diagn Cytopathol. 1997;17(5):347–52.
Wakely PE. Oncocytic and oncocytic-like lesions of the head and neck. Ann Diagn Pathol. 2008;12(3):220–30.
Tjioe KC, de Lima HG, Thompson LD, Lara VS, Damante JH, Oliveira-Santos C. Papillary cystadenoma of minor salivary glands: report of 11 cases and review of the English literature. Head Neck Pathol. 2015;9(3):354–9.
Chin S, Kim HK, Kwak JJ. Oncocytic papillary cystadenoma of major salivary glands: three rare cases with diverse cytologic features. J Cytol. 2014;31(4):221–3.
Wade TV, LiVolsi VA, Montone KT, Baloch ZW. A cytohistologic correlation of mucoepidermoid carcinoma: emphasizing the rare oncocytic variant. Pathol Res Int. 2011;2011:135796.
D’Antonio A, Boscaino A, Caleo A, Addesso M, Orabona P. Oncocytic variant of mucoepidermoid carcinoma: a diagnostic challenge for the pathologist. Indian J Pathol Microbiol. 2015;58(2):201–3.
Katz-Selbst ML, Chhieng DC. Fine needle aspiration biopsy of recurrent oncocytic carcinoma of parotid gland. Diagn Cytopathol. 2009;37(11):849–52.
Collla G, Apicella A, Bove P, Rossiello L, Trodella M, Rossiello R. Oncocytic carcinoma of the accessory lobe of the parotid gland. J Craniofac Surg. 2010;21(6):1987–90.
Schmitt AC, Cohen C, Siddiqui MT. Expression of SOX10 in salivary gland oncocytic neoplasms: a review and comparative analysis with other immunhistochemical markers. Acta Cytol. 2015;59(5):384–90.
Samulski TD, LiVolsi VA, Baloch Z. The cytopathologic features of mammary analog secretory and its mimics. Cytojournal. 2014;11:24.
Tyagi R, Dey P. Diagnostic problems of salivary gland tumors. Diagn Cytopathol. 2015;43(6):495–509.
Layfield LJ, Glasgow BJ. Aspiration cytology of clear-cell lesions of the parotid gland: morphologic features and differential diagnosis. Diagn Cytopathol. 1993;9(6):705–11.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Baloch, Z. et al. (2018). Neoplasm. In: Faquin, W., et al. The Milan System for Reporting Salivary Gland Cytopathology . Springer, Cham. https://doi.org/10.1007/978-3-319-71285-7_5
Download citation
DOI: https://doi.org/10.1007/978-3-319-71285-7_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-71284-0
Online ISBN: 978-3-319-71285-7
eBook Packages: MedicineMedicine (R0)