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Gender Differences in Cardiovascular Drugs

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Abstract

Many common cardiovascular drugs exhibit different therapeutic outcomes and adverse effects between women and men. The different responses may reflect gender-specific variances in drug sensitivities and pharmacokinetic profiles coupled to inherent differences in the underlying physiology of each sex. For example, women have a longer baseline QT interval, as measured by electrocardiogram, compared to men; hence, compared to men, women are more susceptible to lethal ventricular arrhythmias caused by drugs that prolong the QT interval. Equitable inclusion of women subjects in clinical drug trials will improve our knowledge base for assessing the gender- specific risk/benefit ratio for cardiovascular drugs and will enable us to consider gender as one factor in prescribing drugs and adjusting drug loading and maintenance dosages. This chapter reviews current evidence for gender- related differences in the responses to common cardiovascular drugs including statins, antiplatelet and antithrombotic agents, β-blockers, digoxin, calcium channel blockers, isosorbide mononitrate, aldosterone antagonists, and drugs associated with the long QT syndrome.

Keywords

  • Cardiovascular
  • Drugs
  • Therapeutics
  • Medications
  • Gender
  • Side effects
  • Pharmacokinetics

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Correspondence to Nancy J. Rusch Ph.D. .

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Stolarz, A.J., Rusch, N.J. (2018). Gender Differences in Cardiovascular Drugs. In: Mehta, J., McSweeney, J. (eds) Gender Differences in the Pathogenesis and Management of Heart Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-71135-5_16

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  • DOI: https://doi.org/10.1007/978-3-319-71135-5_16

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